Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 673 - 673

Published: Feb. 13, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested administration probiotics in pregnant women at high risk allergies their children. Our study aims to evaluate role administering Bifidobacterium bifidum strain PRL2010 during pregnancy breastfeeding preventing and/or reducing severity AD manifestations It monocentric, randomized, double-blind, placebo-controlled trial with probiotic/placebo since 36th week gestation mothers atopy or family history atopy; effects were evaluated over first 12 months children's lives. No severe adverse due probiotic intake reported our cohort. Although proportionally fewer children group, statistical analysis showed no significant differences between placebo groups. However, infants who developed most forms group better clinical course follow-up compared those group. In conclusion, safe potentially beneficial; further large-scale studies may confirm its usefulness improving manifestation atopy.

Language: Английский

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Eficácia terapêutica de probióticos presentes na composição do kefir em ensaios clínicos recentes

Caderno Pedagógico, Journal Year: 2025, Volume and Issue: 22(4), P. e14216 - e14216

Published: Feb. 18, 2025

O kefir é um consórcio de microrganismos, principalmente probióticos, com diversas propriedades terapêuticas. Este estudo integrativo analisou ensaios clínicos randomizados publicados em 2024, focando na eficácia dos probióticos presentes no kefir. A pesquisa foi realizada nas bases PubMed (MEDELINE), SciELO, ScienceDirect e Scopus. Os resultados indicaram que o kefir, devido à sua diversidade pode proporcionar benefícios significativos saúde. Entre os principais achados, destacam-se a redução triglicerídeos pacientes obesos, diminuição da gordura corporal, níveis colesterol total, melhora inflamação. Além disso, observada promoção do aumento biodiversidade microbiota intestinal, ajudar das infecções gastrointestinais respiratórias. Também houve nos escores depressão síndrome intestino irritável. Esses achados reforçam potencial terapêutico destacam necessidade mais pesquisas para consolidar expandir conhecimento sobre suas aplicações clínicas

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The Role of Short-Chain Fatty Acids, Particularly Butyrate, in Oncological Immunotherapy with Checkpoint Inhibitors: The Effectiveness of Complementary Treatment with Clostridium butyricum 588

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1235 - 1235

Published: June 19, 2024

The discovery of immune checkpoints (CTLA-4, PD-1, and PD-L1) their impact on the prognosis oncological diseases have paved way for development revolutionary treatments. These treatments do not combat tumors with drugs “against” cancer cells but rather support enhance ability system to respond directly tumor growth by attacking lymphocytes. It has now been widely demonstrated that presence an adequate response, essentially represented number TILs (tumor-infiltrating lymphocytes) present in mass decisively influences response disease. Therefore, immunotherapy is based cannot be carried out without increase lymphocytic at site, thereby limiting nullifying certain evasion mechanisms, particularly those expressed activity (under positive physiological conditions) restrain against transformed cells. Immunotherapy experimental phase decades, its excellent results made it a cornerstone many pathologies, especially when combined chemotherapy radiotherapy. Despite these successes, significant patients (approximately 50%) treatment or develop resistance early on. microbiota, composition, our modulate can treatments, reducing side effects increasing sensitivity effectiveness. Numerous studies published high-ranking journals confirm microbial balance, bacteria capable producing short-chain fatty acids (SCFAs), butyrate, essential only chemoradiotherapy also better and, therefore, prognosis. This opens up possibility favorable modulation microbiota could become complementary standard therapies. brief review aims highlight key aspects using precision probiotics, such as Clostridium butyricum, produce butyrate improve checkpoint thus, diseases.

Language: Английский

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Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2916 - 2916

Published: Sept. 1, 2024

Probiotics have shown potential in managing hypercholesterolemia and related metabolic conditions. This study evaluated the effects of Lactocaseibacillus (Lactobacillus) paracasei sup. TISTR 2593 on gut microbiome health patients with hypercholesterolemia, was registered Thai Clinical Trial Registry (TCTR 20220917002). In a randomized, double-blind, placebo-controlled trial, 22 hypercholesterolemic participants received either probiotic or placebo daily for 90 days. Fecal samples collected before after intervention revealed significant changes, including decrease Subdoligranulum, linked to rheumatoid arthritis, an increase Flavonifractor, known its anti-inflammatory properties. Additionally, group exhibited reduction low-density lipoprotein cholesterol (LDL-C) levels. These findings suggest that L. can modulate improve health, warranting further investigation into mechanisms long-term benefits.

Language: Английский

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Intestinal permeability, food antigens and the microbiome: a multifaceted perspective

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 9, 2025

The gut barrier encompasses several interactive, physical, and functional components, such as the microbiota, mucus layer, epithelial layer mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure antibiotics, thus diminishing protective immunity leading onset of chronic diseases. Several gaps knowledge still exist regards multi-level interaction. In review we aim summarize current evidence linking food antigens, microbiota permeability interference diverse disease conditions celiac (CeD), non-celiac wheat sensitivity (NCWS), allergies (FA), eosinophilic gastrointestinal disorder (EOGID) irritable bowel syndrome (IBS). Specific elimination diets are recommended CeD, NCWS, FA some cases EOGID. Undoubtfully, each is very different quite unique, albeit antigens/compounds, intestinal specific signatures orchestrate immune response decide clinical outcomes all them.

Language: Английский

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Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota

Food Science of Animal Resources, Journal Year: 2024, Volume and Issue: 44(6), P. 1417 - 1439

Published: Nov. 1, 2024

The gut microbiota is an immune system regulator in the gut-skin axis. Dysfunctional interactions between and can lead to development of skin diseases such as atopic dermatitis (AD). Probiotics postbiotics positively affect balance microbiota, regulation, protection against pathogens, barrier integrity. This study investigated effects probiotic

Language: Английский

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Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4173 - 4173

Published: Nov. 30, 2024

Allergic Rhinitis (AR) is an atopic disease affecting the upper airways of predisposed subjects exposed to aeroallergens. This study evaluates effects a mix specific probiotics (

Language: Английский

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