Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

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Gut Microbiota Signatures in Colorectal Cancer as a Potential Diagnostic Biomarker in the Future: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7937 - 7937

Published: July 20, 2024

The gut microbiota has acquired significant attention in recent years for its potential as a diagnostic biomarker colorectal cancer (CRC). In this literature review, we looked at the studies exploring alterations composition associated with CRC, mechanisms linking dysbiosis to CRC development, and approaches utilizing analysis. Our research led conclusion that individuals often display their compared healthy individuals. These can include changes diversity, abundance, type of bacteria present gut. While use holds promise, further is needed validate effectiveness standardize testing protocols. Additionally, considerations such variability among factors must be addressed before microbiota-based tests widely implemented clinical practice.

Language: Английский

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Deciphering the metabolic landscape of colorectal cancer through the lens of AhR-mediated intestinal inflammation

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 7, 2025

Colorectal cancer (CRC) ranks as the third most common worldwide, with its incidence steadily increasing due to an aging demographic and various lifestyle-related risk factors, including poor nutrition, tobacco use, sedentary behaviour obesity. These factors promote of colorectal by inducing chronic colonic inflammation, a principal catalyst carcinogenesis. This review delves into evidence that suggests metabolic abnormalities mediated through inflammatory responses are fundamental in progression CRC. dysregulation essential pathways cancer, facilitates tumor proliferation, immune evasion, metastasis. Additionally, this explores how mediators, dietary carcinogens induce alterations, fostering pro-tumorigenic milieu. Special focus is placed on aryl hydrocarbon receptor (AhR) pivotal regulator links inflammation metabolism, elucidating function reconfiguration cellular energetics microenvironment. Furthermore, also focuses clarifying relationship between dysregulation, CRC, so identify potential therapeutic targets.

Language: Английский

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The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive Cross-Reference Study

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 468 - 468

Published: March 15, 2025

Background: The aim of this study is to determine which types microorganisms influence the onset and development colorectal cancer (CRC) in humans. Methods: In patients with CRC, three swabs were taken for microbiological analysis during surgical removal cancer: first swab from surface healthy intestinal mucosa, second tumor, third middle tumor tissue. Results: mucosa colon, most prevalent microorganism was Escherichia coli at 70.5%, followed by Enterococcus spp. (47.7%) Klebsiella/Enterobacter (20.5%). Microbiological tissue showed that E. 72.7%, 40.9%, 25%, Pseudomonas aeruginosa 20%. center tissue, 77.3%, 47.7%, Klebsiella 27%, 18.2%. Conclusion: Certain bacteria can emergence cancer, while other suppress human stool samples prevent CRC.

Language: Английский

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Confrontation of the ambivalent roles of the intestinal microbiota in carcinogenesis: Oncogenic or anticancer agents?

Journal Of Advanced Pharmacy Education And Research, Journal Year: 2025, Volume and Issue: 15(2), P. 16 - 30

Published: Jan. 1, 2025

Language: Английский

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Bacteria displaying cytokines heat up the tumor microenvironment

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

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Exploring the gut microbiome: A potential biomarker for cancer diagnosis, prognosis, and therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189251 - 189251

Published: Dec. 1, 2024

Language: Английский

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