Chlamydia trachomatis: From Urogenital Infections to the Pathway of Infertility DOI Open Access
Rafaela Rodrigues, Carlos Sousa, Alberto Barros

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 205 - 205

Published: Feb. 7, 2025

Chlamydia trachomatis (CT) is a major cause of sexually transmitted infections (STIs) worldwide, with significant implications for reproductive health. The bacterium's genome contains highly polymorphic regions, influencing both the type and severity infections. These genetic variations, particularly those occurring in outer membrane protein (MOMP) gene, are critical classifying bacterium into distinct serovars enable CT to adapt diverse host environments, contributing its immune evasion, persistence, pathogenicity. Persistent or untreated urogenital can lead chronic inflammation, tissue damage, pelvic inflammatory disease, ultimately increasing risk ectopic pregnancy, spontaneous abortion, infertility. This review consolidates current knowledge on diversity CT, potential role modulating infection outcomes, evasion mechanisms. By integrating scientific evidence linking chlamydial infertility, we underscore urgent need targeted research address this public health challenge.

Language: Английский

Chlamydia trachomatis: From Urogenital Infections to the Pathway of Infertility DOI Open Access
Rafaela Rodrigues, Carlos Sousa, Alberto Barros

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 205 - 205

Published: Feb. 7, 2025

Chlamydia trachomatis (CT) is a major cause of sexually transmitted infections (STIs) worldwide, with significant implications for reproductive health. The bacterium's genome contains highly polymorphic regions, influencing both the type and severity infections. These genetic variations, particularly those occurring in outer membrane protein (MOMP) gene, are critical classifying bacterium into distinct serovars enable CT to adapt diverse host environments, contributing its immune evasion, persistence, pathogenicity. Persistent or untreated urogenital can lead chronic inflammation, tissue damage, pelvic inflammatory disease, ultimately increasing risk ectopic pregnancy, spontaneous abortion, infertility. This review consolidates current knowledge on diversity CT, potential role modulating infection outcomes, evasion mechanisms. By integrating scientific evidence linking chlamydial infertility, we underscore urgent need targeted research address this public health challenge.

Language: Английский

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