Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus
Yi-qi Xia,
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Zhenghui Hu,
No information about this author
Qiyuan Jin
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et al.
Computational and Structural Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
27, P. 488 - 500
Published: Jan. 1, 2025
Staphylococcus
aureus
(S.
aureus)
is
a
prevalent
pathogen
associated
with
wide
range
of
infections,
exhibiting
significant
antibiotic
resistance
and
posing
therapeutic
challenges
in
clinical
settings.
The
formation
biofilms
contributes
to
the
emergence
resistant
strains,
further
diminishing
efficacy
antibiotics.
This,
turn,
leads
chronic
recurrent
ultimately
increasing
healthcare
burden.
Consequently,
preventing
eliminating
has
become
critical
focus
management
research.
This
review
systematically
examines
mechanisms
underlying
biofilm
S.
its
contribution
resistance,
emphasizing
essential
roles
play
maintaining
structural
integrity
enhancing
resistance.
It
also
analyses
protective
that
fortify
against
antimicrobial
treatments.
Furthermore,
provides
comprehensive
overview
recent
innovations,
including
enzymatic
therapy,
nanotechnology,
gene
editing,
phage
therapy.
Emerging
strategies
present
novel
approaches
combat
biofilm-associated
infections
through
various
mechanisms.
discusses
advancements
these
therapies,
their
practical
application,
an
in-depth
analysis
each
strategy's
potential.
By
mapping
future
research
directions,
this
aims
refine
anti-biofilm
control
infection
progression
effectively
mitigate
recurrence.
Language: Английский
Biofilm-Mediated Infections; Novel Therapeutic Approaches and Harnessing Artificial Intelligence for Early Detection and Treatment of Biofilm-Associated Infections
Muhammad Bilal Habib,
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Ghanwa Batool,
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Naseer Ali Shah
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et al.
Microbial Pathogenesis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107497 - 107497
Published: March 1, 2025
Language: Английский
A Narrative Review of Fungal Periprosthetic Joint Infections of the Hip and Knee: Risk Factors, Microbiological Profiles, and Treatment Challenges
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(1), P. 206 - 206
Published: Jan. 2, 2025
Fungal
periprosthetic
joint
infections
(PJIs)
are
rare
but
increasingly
recognized
complications
following
total
arthroplasty
(TJA).
While
Candida
albicans
remains
the
most
common
pathogen,
non-albicans
species
and
other
fungi,
such
as
Aspergillus,
have
gained
prominence.
These
often
present
with
subtle
clinical
features
affect
patients
significant
comorbidities
or
immunosuppression.
Compared
to
bacterial
PJIs,
fungal
pose
unique
diagnostic
therapeutic
challenges,
including
biofilm
formation,
limited
antifungal
susceptibility,
protracted
treatment
courses.
This
narrative
review
synthesizes
current
evidence
from
research
articles
review/metanalysis
papers,
focusing
on
PJIs.
The
literature
search
encompassed
publications
2015
2024,
identifying
key
insights
epidemiology,
risk
factors,
microbiological
profiles,
methods,
strategies,
outcomes.
Both
classical
references
recent
studies
addressing
emerging
biomarkers
biofilm-active
therapies
were
included.
It
was
shown
that
C.
primary
pathogen
in
PJIs
fungi
associated
more
complex
scenarios,
higher
recurrence
rates,
reduced
infection-free
survival.
Patients
commonly
exhibit
multiple
comorbidities,
compromised
immune
status,
previous
prosthetic
revisions.
Diagnosis
is
complicated
by
slow-growing
organisms
nonspecific
inflammatory
markers,
prompting
interest
novel
diagnostics
alpha-defensin,
calprotectin,
next-generation
sequencing.
Two-stage
revision
arthroplasty,
supplemented
prolonged
targeted
therapy,
considered
gold
standard
for
chronic
infections,
although
outcomes
remain
inferior
Emerging
antifungal-impregnated
beads
biofilm-disrupting
agents,
may
improve
local
infection
control.
In
conclusion,
constitute
a
challenging
entity
demanding
tailored
approaches.
Further
into
standardized
criteria,
optimized
regimens,
biomarker
validation,
refined
surgical
strategies
essential.
Multidisciplinary
collaboration,
enhanced
patient
optimization,
innovative
biofilm-directed
hold
promise
improving
reducing
burden
of
Language: Английский
The Hidden Fortress: A Comprehensive Review of Fungal Biofilms with Emphasis on Cryptococcus neoformans
Hope M. Pruitt,
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Jinyi C. Zhu,
No information about this author
Sean P. Riley
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et al.
Journal of Fungi,
Journal Year:
2025,
Volume and Issue:
11(3), P. 236 - 236
Published: March 19, 2025
Biofilms
are
structurally
organized
communities
of
microorganisms
that
adhere
to
a
variety
surfaces.
These
produce
protective
matrices
consisting
polymeric
polysaccharides,
proteins,
nucleic
acids,
and/or
lipids
promote
shared
resistance
various
environmental
threats,
including
chemical,
antibiotic,
and
immune
insults.
While
algal
bacterial
biofilms
more
apparent
in
the
scientific
zeitgeist,
many
fungal
pathogens
also
form
biofilms.
surprisingly
common
morphologically
distinct
from
multicellular
molds
mushrooms
normally
associated
with
fungi
instead
an
assemblage
single-celled
organisms.
As
collection
yeast
filamentous
cells
cloaked
extracellular
matrix,
extreme
threat
public
health,
especially
conjunction
surgical
implants.
The
encapsulated
yeast,
Cryptococcus
neoformans,
is
opportunistic
pathogen
causes
both
pulmonary
disseminated
infections,
particularly
immunocompromised
individuals.
However,
there
emerging
trend
cryptococcosis
among
otherwise
healthy
C.
neoformans
forms
diverse
environments,
within
human
hosts.
Notably,
biofilm
association
correlates
increased
expression
multiple
virulence
factors
host
defenses
antifungal
treatments.
Thus,
it
crucial
develop
novel
strategies
combat
In
this
review,
we
discuss
development
treatment
biofilms,
particular
focus
on
neoformans.
Language: Английский
Viscosupplementation and Synovial Fluid Rheology: A Hidden Risk for Bacterial Biofilm Formation in Joint Infections?
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 700 - 700
Published: March 21, 2025
Synovial
fluid
(SF)
plays
a
critical
role
in
joint
lubrication,
load
distribution,
and
maintaining
homeostasis
within
the
synovial
cavity.
Its
rheological
properties,
primarily
influenced
by
hyaluronic
acid
(HA)
other
macromolecules,
are
essential
for
normal
function.
However,
alterations
physicochemical
characteristics
of
SF
can
occur
due
to
septic
conditions,
including
arthritis
(SA)
periprosthetic
infections
(PJIs),
which
significantly
impact
health.
Bacterial
colonization
infected
joints
often
leads
formation
biofilms,
microbial
aggregates
encased
an
extracellular
matrix,
confer
resistance
antibiotics
host
immune
responses.
Biofilm
SF-altered
environments
is
major
challenge
treating
infections,
particularly
patients
with
prosthetic
implants.
Viscosupplementation,
through
intra-articular
injections,
has
been
widely
used
restore
viscosity
function
degenerative
diseases.
More
recently,
polyacrylamide
(PAA)-based
gels
have
emerged
as
alternative
viscosupplementation
strategy.
concerns
raised
regarding
potential
viscosupplements
on
biofilm
bacterial
adhesion
joints,
changes
composition
may
influence
persistence.
This
review
aims
assess
interaction
between
pathologies,
examining
effects
HA
PAA
rheology
adhesion.
Understanding
these
interactions
crucial
optimizing
therapeutic
strategies
mitigating
risk
biofilm-associated
undergoing
viscosupplementation.
Language: Английский
Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration
Paweł Mikziński,
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Karolina Kraus,
No information about this author
Rafał Seredyński
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et al.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(11), P. 2323 - 2323
Published: May 26, 2025
Photocatalysis
and
photodynamic
therapy
have
been
increasingly
used
in
the
management
of
diabetic
foot
ulcers
(DFUs),
their
integration
into
innovative
treatment
protocols
enables
effective
infection
control.
Advanced
techniques
such
as
antibacterial
(aPDT),
liposomal
photocatalytic
carriers,
nanoparticles,
nanomotors—used
alone,
combination,
or
with
addition
antibiotics,
lysozyme,
phage
enzymes—offer
promising
solutions
for
wound
treatment.
These
approaches
are
particularly
even
presence
comorbidities
angiopathies,
neuropathies,
immune
system
disorders,
which
common
among
patients.
Notably,
use
combination
therapies
holds
great
potential
addressing
challenges
within
ulcers,
including
hypoxia,
poor
circulation,
high
glucose
levels,
increased
oxidative
stress,
rapid
biofilm
formation—factors
that
significantly
hinder
healing
The
modern
therapeutic
strategies
is
essential
clinical
practice,
starting
halting
progression,
ensuring
its
eradication,
promoting
proper
tissue
regeneration,
especially
considering
that,
according
to
WHO,
830
million
people
worldwide
suffer
from
diabetes.
Language: Английский
Prevention and Modern Strategies for Managing Methicillin-Resistant Staphylococcal Infections in Prosthetic Joint Infections (PJIs)
Karolina Kraus,
No information about this author
Paweł Mikziński,
No information about this author
Jarosław Widelski
No information about this author
et al.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1151 - 1151
Published: Dec. 1, 2024
Periprosthetic
joint
infections
(PJIs)
are
a
dangerous
complication
of
replacement
surgeries
which
have
become
much
more
common
in
recent
years
(mostly
hip
and
knee
surgeries).
Such
condition
can
lead
to
many
health
issues
often
requires
reoperation.
Staphylococci
is
bacterial
group
most
terms
the
pathogens
causing
PJIs.
S.
aureus
coagulase-negative
staphylococci
found
around
two-thirds
PJI
cases.
Recently,
numbers
that
cause
such
methicillin-resistant
increasing.
This
trend
leads
difficulties
treatment
prevention
infections.
That
why
MRSA
MRSE
groups
require
extraordinary
attention
when
dealing
with
PJIs
order
successfully
treat
them.
Controlling
carriage,
using
optimal
prosthetic
materials,
implementing
perioperative
antimicrobial
prophylaxis
crucial
strategies
infection
as
essential
quick
diagnosis
effective
targeted
treatment.
The
comprehensive
professional
procedures
presented
this
review
show
how
deal
Language: Английский
Safety of Intraoperative Cell Salvage in Two-Stage Revision of Septic Hip Arthroplasties
Lara Krüger,
No information about this author
André Strahl,
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Eva Goedecke
No information about this author
et al.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(9), P. 902 - 902
Published: Sept. 21, 2024
(1)
Background:
The
aim
of
this
study
was
to
evaluate
the
safety
intraoperative
cell
salvage
(ICS)
during
reimplantation
in
two-stage
revision
septic
hip
arthroplasties.
(2)
Methods:
As
part
an
internal
quality
control
study,
blood
cultures
were
taken
from
processed
ICS
and
examined
for
possible
bacterial
load
(study
group).
Due
a
high
rate
detection
with
uncertain
clinical
significance,
consecutive
samples
also
patients
undergoing
aseptic
arthroplasty
(control
Microbiological
samples,
patient
surgical
characteristics
follow-up
data
analyzed
retrospectively.
(3)
Results:
9
out
12
(75%)
group
5
8
(63%)
had
positive
cultures.
There
no
significant
difference
between
groups
(p
=
0.642).
initial
pathogens
causing
periprosthetic
joint
infection
(PJI)
not
detected,
but
spectrum
resembled
skin
flora,
proportion
coagulase-negative
staphylococci.
No
complications
due
bloodstream-associated
infections
observed.
In
summary,
detected
interpreted
as
contamination
without
significance.
(4)
Conclusions:
context
considered
safe
recommendable
procedure
optimize
management.
Language: Английский