Lesser-Known Cyanotoxins: A Comprehensive Review of Their Health and Environmental Impacts DOI Creative Commons

Molham Al Haffar,

Ziad Fajloun, Sami T. Azar

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 551 - 551

Published: Dec. 19, 2024

Cyanobacteria, also known as blue-green algae, are a diverse phylum of photosynthetic, Gram-negative bacteria and one the largest microbial taxa. These organisms produce cyanotoxins, which secondary metabolites that can have significant impacts on both human health environment. While toxins like Microcystins Cylindrospermopsins well-documented been extensively studied, other including those produced by Lyngbya Nostoc, remain underexplored. lesser-known cause various issues in humans, neurotoxicity, hepatotoxicity, dermatotoxicity, each through distinct mechanisms. Moreover, recent studies shown cyanobacteria be aerosolized transmitted air over long distances, providing an additional route for exposure to their harmful effects. However, it remains area requires much more investigation accurately assess risks develop appropriate public guidelines. In addition direct toxins, lead algal blooms, pose further wildlife health, global concern. There is limited knowledge about these highlighting need research understand clinical manifestations improve society’s preparedness associated risks. This work aims review existing literature underexplored with intoxication, elucidate relevance, address challenges cyanobacterial research, provide guidance mitigating adverse

Language: Английский

Immunosenescence: How Aging Increases Susceptibility to Bacterial Infections and Virulence Factors DOI Creative Commons
Nikolaos Theodorakis, Georgios Feretzakis, Christos Hitas

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 2052 - 2052

Published: Oct. 11, 2024

The process of aging leads to a progressive decline in the immune system function, known as immunosenescence, which compromises both innate and adaptive responses. This includes impairments phagocytosis decreased production, activation, function T- B-lymphocytes, among other effects. Bacteria exploit immunosenescence by using various virulence factors evade host’s defenses, leading severe often life-threatening infections. manuscript explores complex relationship between bacterial virulence, focusing on underlying mechanisms that increase vulnerability infections elderly. Additionally, it discusses how machine learning methods can provide accurate modeling interactions weakened mechanisms, guiding development personalized interventions. vaccines, novel antibiotics, antivirulence therapies for multidrug-resistant bacteria, well investigation potential immune-boosting therapies, are promising strategies this field. Future research should focus approaches be integrated with immunological, microbiological, clinical data develop interventions improve outcomes growing elderly population.

Language: Английский

Citations

6
Antimicrobial Peptides From Different Sources: Isolation, Purification, and Characterization to Potential Applications DOI Open Access
Shadi Ali Hassen Ahmed, Bassam Saif, Linghui Qian

et al.

Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(23)

Published: Dec. 1, 2024

ABSTRACT Antimicrobial peptides (AMPs) are excellent promising candidates for biomedical applications owing to their structural properties, high biocompatibility, good biodegradability, and functional diversity. Unlike conventional antibiotics, AMPs have been shown broad‐spectrum antimicrobial activity toward Gram‐positive/negative bacteria, as well antifungal antiviral activity. These also found be cytotoxic sperm cancer cells. A range of has isolated from various organisms, such fungi, plants, animals. This review summarizes the latest studies on AMPs, covering isolation, purification, characterization potential beyond.

Language: Английский

Citations

4
Examining Alternative Approaches to Antibiotic Utilisation: A Critical Evaluation of Phage Therapy and Antimicrobial Peptides Combination as Potential Alternatives DOI Creative Commons

Chibuzo V. Alisigwe,

Chibuzor Stanley Ikpa,

Uchenna Joseph Otuonye

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100254 - 100254

Published: Jan. 1, 2025

Language: Английский

Citations

0
Proline-Modified (RW)n Peptides: Enhancing the Antimicrobial Efficacy and Selectivity against Multidrug-Resistant Pathogens DOI Creative Commons
Anderson Sunda‐Meya,

Nsoki Phambu

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

The growing threat of multidrug-resistant (MDR) bacteria necessitates the development novel antimicrobial agents. This study investigates potential proline-modified (RW)n peptides as a platform for combating MDR pathogens with minimal toxicity. We synthesized and evaluated (n = 4, 6, 8) without central proline residues against five clinically relevant bacterial strains, including ESKAPE pathogens. Antimicrobial activity, cytotoxicity, synergistic effects conventional antibiotics were assessed. Proline incorporation significantly enhanced peptide selectivity broadened spectrum particularly Gram-negative bacteria. RW6P RW8P demonstrated exceptional efficacy (MICs ≤ 0.25 μg/mL) methicillin-resistant Staphylococcus aureus Escherichia coli toxicity to human cells. Notably, restored ampicillin susceptibility in Pseudomonas aeruginosa (MIC < dose-dependent Exceptionally, RW6-2P all Gram-positive bacteria, except Klebsiella pneumoniae (Kp), Furthermore, several isolates rendered susceptible vancomycin when combined these peptides, addressing key limitation glycopeptide antibiotics. (Kp) was RW4P RW6-2P. RW6-2P, antibiotics, have shown selectivity. presents promising candidates developing broad-spectrum antimicrobials revitalize existing

Language: Английский

Citations

0
Reviewing on AI‐Designed Antibiotic Targeting Drug‐Resistant Superbugs by Emphasizing Mechanisms of Action DOI Open Access
Zafer Yönden,

Samira Reshadi,

Ahmad Farrokh Hayati

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

ABSTRACT The emergence of drug‐resistant bacteria, often referred to as “superbugs,” poses a profound and escalating challenge global health systems, surpassing the capabilities traditional antibiotic discovery methods. As resistance mechanisms evolve rapidly, need for innovative solutions has never been more critical. This review delves into transformative role AI‐driven methodologies in development, particularly targeting bacterial strains (DRSBs), with an emphasis on understanding their action. AI algorithms have revolutionized process by efficiently collecting, analyzing, modeling complex datasets predict both effectiveness potential antibiotics resistance. These computational advancements enable researchers identify promising candidates unique that effectively bypass conventional pathways. By specifically critical processes or disrupting essential cellular components, these AI‐designed offer robust combating even most resilient strains. application design represents paradigm shift, enabling rapid precise identification novel compounds tailored approach not only accelerates drug development timeline but also enhances precision superbugs, significantly improving therapeutic outcomes. Furthermore, underlying is crucial optimizing clinical efficacy devising proactive strategies prevent further poised play pivotal fight against antimicrobial leveraging power artificial intelligence, are opening new frontiers effective treatments, ensuring sustainable response growing threat bacteria.

Language: Английский

Citations

0
Identification and characterisation of LEAP2 from Chinese spiny frogs (Quasipaa spinosa) with antimicrobial and macrophage activation properties DOI Creative Commons

Ping Ying,

Xueyu Qian,

Zixuan Wang

et al.

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 13, 2025

Abstract Background The liver-expressed antimicrobial peptide 2 (LEAP2) family is an important group of peptides (AMPs) involved in vertebrate defence against bacterial infections. However, research on LEAP2 amphibians still its infancy. Results This study aimed to explore the role Chinese spiny frog ( Quasipaa spinosa ). cDNA gene QsLEAP2 ) was cloned from a frog. protein comprises signal peptide, prodomain, and mature peptide. Sequence analysis indicated that member amphibian cluster closely related African clawed Xenopus laevis Expression detected various tissues, with liver exhibiting highest expression. Following infection Aeromonas hydrophila , expression significantly upregulated spleen, lungs, kidneys, liver, gut. synthetic exhibited selective activity several strains vitro. It disrupted membrane integrity hydrolysed genomic DNA, bactericidal effects specific species. Furthermore, induced chemotaxis RAW264.7 murine leukemic monocytes/macrophages, enhancing their phagocytic respiratory bursts. Docking simulations revealed interaction between QsMOSPD2. Conclusions These findings provide new insights into immune system.

Language: Английский

Citations

0
Antimicrobial Resistance: Linking Molecular Mechanisms to Public Health Impact DOI Creative Commons
Ghazala Muteeb,

Raisa Nazir Ahmed Kazi,

Mohammad Aatif

et al.

SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100232 - 100232

Published: April 1, 2025

Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) efflux pumps (MexAB-OprM) working with mobile elements facilitate fast proliferation of multidrug-resistant (MDR) exttreme drug-resistant (XDR) phenotypes thus creating major concerns for healthcare systems community as well the agricultural sector. The review dissimilarly unifies molecular pathways public implications study epidemiological data monitoring approaches innovative therapeutic solutions. Previous studies separating their attention between genetics clinical outcomes have been combined our approach delivers an all-encompassing analysis AMR. report investigates mechanisms feature enzymatic degradation pump overexpression together target modification horizontal gene transfer because these factors represent important contributors present-day AMR developments. This effects on hospital environments where it affects pathogens including MRSA, carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa. document explores modern management methods that comprise WHO GLASS surveillance three strategies such CRISPR-modified genome editing bacteriophage treatments along peptides artificial intelligence diagnostic tools. resolution needs complete scientific global operational alongside state-of-the-art approaches. Worldwide infection burden requires both enhanced prevention procedures next-generation reduce cases effectively.

Language: Английский

Citations

0
How Machine Learning Helps in Combating Antimicrobial Resistance: A Review of AMP Analysis and Generation Methods DOI

Khalit Musin,

Elvina Asyanova

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 15, 2025

Language: Английский

Citations

0
Recent approaches in the application of antimicrobial peptides in food preservation DOI
Satparkash Singh,

Bhavna Jha,

Pratiksha Tiwari

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(10)

Published: Sept. 9, 2024

Language: Английский

Citations

3
Structural Dynamics and Algorithmic Suitability of Gut-Derived Amps: A Comparative Study of Computational Modeling Approaches DOI
Ananya Anurag Anand,

Sarfraz Anwar,

Vidushi Yadav

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0