Case report on Clostridium perfringens-induced gas gangrene following an intramuscular injection: A stark reminder of injection-associated risks

International Journal of Surgery Case Reports, Journal Year: 2025, Volume and Issue: unknown, P. 111236 - 111236

Published: March 1, 2025

This case reports Clostridium perfringens-induced gas gangrene and compartment syndrome after an intramuscular NSAID injection in immunocompetent patient, uncommon occurrence without typical risk factors. Despite limited access to advanced wound care, prompt surgical debridement, broad-spectrum antibiotics, intensive support ensured survival. A 37-year-old male developed severe pain, blackish skin discoloration, rapidly progressing swelling of the right deltoid receiving diclofenac injection. Within 24-30 h, he exhibited sepsis syndrome. Emergency fasciotomy debridement were performed, cultures confirmed a polymicrobial infection, including perfringens. He was treated with serial leading gradual recovery. After three weeks hospitalization, discharged stable condition follow-up for care grafting. Clostridial myonecrosis, or gangrene, is fast-progressing, life-threatening infection. Strict aseptic techniques cautious administration are crucial prevent iatrogenic clostridial infections. Additionally, lack Negative Pressure Wound Therapy (NPWT) resource-limited settings underscores disparities need alternative management strategies. Further research warranted identify modifiers improve early diagnostic markers myonecrosis patients. Early recognition, immediate intervention, multidisciplinary remain critical Improved awareness sterile practices vigilance can help detect such rare but devastating

Language: Английский

Clostridium septicum-associated myonecrosis in a dog: case report

Veterinary Research Communications, Journal Year: 2025, Volume and Issue: 49(3)

Published: March 28, 2025

Language: Английский

Lumbar Spondylodiscitis Caused by Clostridium perfringens: A Case Report Highlighting Diagnostic Challenges and Conservative Management

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

This case report describes a 70-year-old male with history of hepatic cirrhosis and diabetes who was admitted severe low back pain, fever, sepsis. Initially, the pain appeared consistent muscle strain. However, persistence symptoms, ongoing patient's underlying conditions raised suspicion for more serious pathology. Blood cultures identified Clostridium perfringens, MRI confirmed L4-L5 spondylodiscitis accompanied by an epidural abscess. rare musculoskeletal infection, known its high mortality risk, successfully treated targeted antibiotic therapy alone, as there were no neurological deficits to warrant surgical intervention. After nine weeks treatment, follow-up showed resolution abscess, patient made full clinical recovery. The likely mechanism in this is bacterial translocation driven portal hypertension immune dysregulation associated liver cirrhosis. underscores importance investigating causes patients presenting red flag it demonstrates that conservative management can be effective without involvement, even when caused high-risk pathogens such C. perfringens.

Language: Английский