The Vaginal Microbiome: Patient- versus Physician-Collected Microbial Swab: A Pilot Study

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1859 - 1859

Published: Sept. 7, 2024

The composition of the vaginal microbiota prior to an IVF/IVF-ICSI treatment can predict chance achieving a pregnancy. To improve clinical applicability and be more patient-friendly, self-collection samples would preferable. However, reliability patient-collected compared physician-collected remains unclear. This study compares microbiome outcomes from versus samples. is prospective pilot consisting two cohorts: Cohort I involved patient self-sampling vagina, followed by swab, while II reversed order collection. interspace profiling (IS-Pro) technique was used analyze in all From May 2021 March 2022, total 444 were collected n = 222 patients (aged 21–44 years), with (n 109) 113). both cohorts highly similar, regardless sampling order, mean cosine similarity 0.93 (95% CI 0.91, 0.95) 0.94 0.92, 0.96) II. Furthermore, ANOVA analysis revealed no significant differences bacterial species abundance between physician- samples, nor first second sample collections. considered comparable indicates patient-friendly convenient collection outpatient setting.

Language: Английский

Probiotics in the Prophylaxis of Premature Rupture of Membranes and Cervical Incompetence

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4230 - 4230

Published: Dec. 6, 2024

Premature rupture of membranes (PROM) and cervical incompetence (CI) are major contributors to preterm birth, a leading cause neonatal morbidity mortality.

Language: Английский