Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 2, 2025

The exploration of microorganisms in fermented products has become a pivotal area scientific research, primarily due to their widespread availability and profound potential improve human health. Among these, Lactiplantibacillus plantarum (formerly known as Lactobacillus plantarum) stands out versatile lactic acid bacterium, prevalent across diverse ecological niches. Its appeal extends beyond its well-documented probiotic benefits include the remarkable plasticity genome, which captivated both industrial stakeholders. Despite this interest, substantial challenges persist fully understanding harnessing L. plantarum. This review aims illuminate attributes plantarum, consolidate current advancements gene editing technologies, explore multifaceted applications wild-type genetically engineered strains.

Language: Английский

Therapeutic targeting of the host-microbiota-immune axis: implications for precision health

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

The human body functions as a complex ecosystem, hosting trillions of microbes that collectively form the microbiome, pivotal in immune system regulation. host-microbe immunological axis maintains homeostasis and influences key physiological processes, including metabolism, epithelial integrity, neural function. Recent advancements microbiome-based therapeutics, probiotics, prebiotics fecal microbiota transplantation, offer promising strategies for modulation. Microbial therapies leveraging microbial metabolites engineered bacterial consortia are emerging novel therapeutic strategies. However, significant challenges remain, individual microbiome variability, complexity interactions, need precise mechanistic insights. This review comprehensively examines host elucidating its mechanisms, potential, future directions immunomodulation health. It will also critically evaluate challenges, limitations, precision medicine.

Language: Английский

Understanding the Functionality of Probiotics on the Edge of Artificial Intelligence (AI) Era

Fermentation, Journal Year: 2025, Volume and Issue: 11(5), P. 259 - 259

Published: May 5, 2025

This review focuses on the potential utilization of artificial intelligence (AI) tools to deepen our understanding probiotics, their mode action, and technological characteristics such as survival. To that end, this provides an overview current knowledge probiotics well next-generation probiotics. AI-aided omics technologies, including genomics, transcriptomics, proteomics, offer new insights into genetic functional properties Furthermore, AI can be used elucidate key probiotic activities microbiota modulation, metabolite production, immune system interactions enable improved health impacts. Additionally, technologies facilitate precision in identifying impacts, role gut health, anticancer activity, antiaging effects. Beyond applications, expand use optimizing storage survival broadening biotechnological approaches. In context, addresses how AI-driven approaches facilitated by strengthening evaluation characteristics, explaining mechanisms enhancing applications. Moreover, enhance impact assessments optimize industrial applications is highlighted, concluding with future perspectives transformative research.

Language: Английский