Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 280 - 280

Published: Dec. 31, 2024

Bone marrow transplantation (BMT) is mainly performed to restore an anti-tumor immune response, called the graft-versus-tumor (GVT) effect, against leukemia, myeloma and lymphoma. This GVT reactivity driven by donor T cells, it can also cause lethal graft-versus-host disease (GVHD). We previously demonstrated that colonization of mice with helminths preserves response while suppressing GVHD. As helper-2 (Th2) pathway critical helminthic regulation, we asked whether genetic induction Th2 signaling in cells regulation after BMT. Our studies utilized transgenic lymphocytes overexpress a constitutively active form Th2-associated transcription factor STAT6. Constitutively STAT6 sustained without causing severe acute GVHD, where generated robust quantities cytotoxic proteins important such as granzymes A B, interferon-γ Fas ligand, addition generating high Th2/regulatory cytokines. Bioinformatic analysis based on chromosome precipitation experiments indicated stimulates expression directly. Thus, preserving GVHD mortality, our results indicate therapeutic potential restoring modulation targeting STAT6-dependent cell maturation.

Language: Английский