RNA Modification in Metabolism DOI Creative Commons
Yadi Liu,

Zhongyan Sun,

Dingkun Gui

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Language: Английский

Deciphering the Host-Pathogen Interface in COVID-19: The precision molecular insight into epitranscriptomic modifications of high-impact transcripts DOI Creative Commons
Mateusz Maździarz, Katarzyna Krawczyk, Ewa Lepiarczyk

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

ABSTRACT The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact since its emergence in late 2019. Characterized wide spectrum of clinical manifestations, ranging from asymptomatic infection to distress and death, necessitated extensive research into host-pathogen interactions that drive disease progression. Understanding molecular mechanisms underlying host response SARS-CoV-2 is crucial for development effective therapeutic interventions preventative strategies. This study employed multi-omic approach combined direct RNA sequencing (DRS) Illumina cDNA investigate whole blood transcriptomic profiles patients. By leveraging unique capabilities Nanopore DRS, which provides long-read data, we were able capture not only gene expression levels but also modifications, including poly(A) tail length, non-adenine residue (non-A), pseudouridylation (psU), 5-methylcytosine (m5C) methylation. comprehensive analysis allowed us identify differentially expressed genes (DEGs) explore these modifications on function within context COVID-19. Our findings reveal significant alterations patterns, lengths, non-A prevalence psU m5C patients compared healthy controls. These results provide valuable insights complex interplay between viral infection, immune response, processing, contributing deeper understanding pathogenesis.

Language: Английский

Citations

0
RNA Modification in Metabolism DOI Creative Commons
Yadi Liu,

Zhongyan Sun,

Dingkun Gui

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Language: Английский

Citations

0