The Roles of IL-6, IL-8, and TNF-α in Pediatric Immune Defense and Infection Severity DOI Open Access
Monday Obaji, Angus Nnamdi Oli, Malachy Ugwu

et al.

OBM Genetics, Journal Year: 2025, Volume and Issue: 09(02), P. 1 - 28

Published: April 23, 2025

Cytokines are pivotal regulators of immune responses. They critical in mediating inflammation, recruiting cells, and driving pathogen clearance. Among these, interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) stand out as key players pediatric immunity, they exhibit unique expression patterns that reflect the dynamic nature developing system. This review explores dual roles these cytokines orchestrating defense their potential diagnostic biomarkers for infection severity children. It highlights how elevated IL-6, IL-8, TNF-α levels correlate with bacterial, viral, fungal infections discusses utility distinguishing between etiologies. The article pinpoints current technologies cytokine detection impact on early diagnosis risk stratification. relevance cytokine-targeted therapies managing hyperinflammatory states is highlighted argued integrating profiling other diagnostics personalized medicine has transformative healthcare. These would pave way more precise, timely, effective management infections.

Language: Английский

A Targeted Mass Spectrometric Approach to Evaluate the Anti-Inflammatory Activity of the Major Metabolites of Foeniculum vulgare Mill. Waste in Human Bronchial Epithelium DOI Creative Commons

Maria Assunta Crescenzi,

Héctor Gallart‐Ayala, Cristiana Stellato

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1407 - 1407

Published: March 21, 2025

Fennel waste is rich in compounds that may have beneficial effects on human health. For this reason, the most abundant metabolites fennel were isolated as following: quercetin-3-O-glucoside, quinic acid, 1,5-dicaffeoylquinic kaempferol-3-O-glucuronide, and quercetin-3-O-glucuronide. After inducing inflammation bronchial epithelial cells by stimulating them with IL-1β, treated specialized Foeniculum vulgare at different concentrations to assess their anti-inflammatory effect. Eicosanoids, fatty acids, sphingolipids extracted from cell medium quantified UPLC-ESI-QTRAP-MS/MS analysis. The activity of was demonstrated. They able alleviate inflammatory state epithelium modulating metabolic expression both pro- eicosanoids, sphingolipids. These findings suggest potential use production dietary supplements symptoms chronic diseases like asthma, obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF), where continuous antiphlogistics significant side effects.

Language: Английский

Citations

0
Exploring quercetin based nano formulation in combating human Metapneumovirus infections DOI
V. Bhuvaneshwari,

Ramasamy Amsaveni

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114510 - 114510

Published: March 24, 2025

Language: Английский

Citations

0
The Roles of IL-6, IL-8, and TNF-α in Pediatric Immune Defense and Infection Severity DOI Open Access
Monday Obaji, Angus Nnamdi Oli, Malachy Ugwu

et al.

OBM Genetics, Journal Year: 2025, Volume and Issue: 09(02), P. 1 - 28

Published: April 23, 2025

Cytokines are pivotal regulators of immune responses. They critical in mediating inflammation, recruiting cells, and driving pathogen clearance. Among these, interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) stand out as key players pediatric immunity, they exhibit unique expression patterns that reflect the dynamic nature developing system. This review explores dual roles these cytokines orchestrating defense their potential diagnostic biomarkers for infection severity children. It highlights how elevated IL-6, IL-8, TNF-α levels correlate with bacterial, viral, fungal infections discusses utility distinguishing between etiologies. The article pinpoints current technologies cytokine detection impact on early diagnosis risk stratification. relevance cytokine-targeted therapies managing hyperinflammatory states is highlighted argued integrating profiling other diagnostics personalized medicine has transformative healthcare. These would pave way more precise, timely, effective management infections.

Language: Английский

Citations

0