Probiotics′ Effects on Depression, High‐Sensitivity C‐Reactive Protein (hs‐CRP), and Oxidative Stress in Patients With Multiple Sclerosis: A Meta‐Analysis

International Journal of Clinical Practice, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objectives: Major depressive disorder (MDD) is highly prevalent in patients with multiple sclerosis (MS). There evidence that the gut microbiota affect inflammatory responses and oxidative status MS may depression signs symptoms these patients. Based on this fact, updated meta‐analysis assessed effect of probiotic supplementation Beck Depression Inventory (BDI), high‐sensitivity C‐reactive protein (hs‐CRP), total antioxidant capacity (TAC), malondialdehyde (MDA) MS. Methods: A systematic literature search was done for English through PubMed/Medline, Cochrane Library, Google Scholar, ScienceDirect from 1 January 2011 to June 2024. This study followed PRISMA guidelines. heterogeneity, random‐effects or fixed‐effects models were used present meta‐analysis. Results: After checking eligibility, four RCTs included final analysis. an improvement BDI‐II score, hs‐CRP level, MDA, TAC (BDI‐II score: MD = −2.78; 95% CI, −3.32 −2.24; Z 10.09; p < 0.00001; I 2 57%; 0.1; level: −1.69; −1.98 −1.40; 11.38; 0%; 0.96; MDA: −0.37; −0.52 −0.23; 5.00; 90%; 0.0001; TAC: 5.48; −6.71 17.66; 0.88; 0.38; 93%; 0.00001). Conclusion: suggests has improved BDI scores status. finding promises can be considered as a therapeutic option However, more interventional studies are required assess complex relationship between MS, depression, microbiome. PROSPERO Registration ID: CRD42024552648.

Language: Английский

Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, transforming growth factor-β (TGF-β), are essential for controlling cellular activity immunological responses, maintaining homeostasis contributing to the pathogenesis of psoriasis. These molecules modulate microenvironment by either promoting or suppressing inflammation, which significantly impacts therapeutic outcomes. Recent research indicates treatment strategies targeting chemokines have significant potential, offering new approaches regulating system, inhibiting progression reducing adverse effects traditional therapies. This review consolidates current knowledge on cytokine chemokine signaling pathways in psoriasis examines their significance treatment. Specific attention given like IL-17, IL-23, TNF-α, underscoring necessity innovative therapies these address processes. emphasizes principal part -pathological process explores challenges opportunities they present intervention. Furthermore, we examine recent advancements targeted therapies, with particular focus monoclonal antibodies, ongoing clinical trials.

Language: Английский