Efficacy of Intravenous Immunoglobulins and Other Immunotherapies in Neurological Disorders and Immunological Mechanisms Involved DOI Creative Commons
Angel A Justiz-Vaillant,

Sachin Soodeen,

Odalis Asin-Milan

et al.

Immuno, Journal Year: 2025, Volume and Issue: 5(2), P. 18 - 18

Published: May 26, 2025

This review aims to explore the role of immunotherapeutic strategies—primarily intravenous immunoglobulin (IVIG), plasma exchange (PLEX), and selected immunomodulatory agents—in treatment neurological psychiatric disorders with suspected or confirmed autoimmune mechanisms. A central focus is placed on understanding immunopathology these conditions through identification characterization disease-associated autoantibodies. Disorders such as encephalitis, myasthenia gravis, limbic epilepsy, neuropsychiatric systemic lupus erythematosus (NPSLE), certain forms schizophrenia have shown clinical responses immunotherapy, suggesting an underlying basis in a subset patients. The also highlights diagnostic relevance detecting autoantibodies targeting neuronal receptors, NMDA AMPA neuromuscular junction components, biomarkers that guide therapeutic decisions. Furthermore, we synthesize findings from published randomized controlled trials (RCTs) validated efficacy IVIG PLEX specific diseases, Guillain–Barré syndrome, gravis. Emerging evidence supports expanding treatments other where autoimmunity implicated. By integrating immunological insights trial data, this offers comprehensive perspective how immunotherapies may be tailored target contributors disease.

Language: Английский

Comprehensive wound healing using ETN@Fe7S8 complex by positively regulating multiple programmed phases DOI Creative Commons
Mengxia Chen, Jia Liu, Xiaonan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 13, 2025

Wound healing requires coordinated progression through multiple programmed phases including hemostasis, infection control, inflammatory resolution, proliferation, and tissue remodeling. Many nanomaterials have shown great potential to promote wound healing, however, most of them only address partial aspects these processes, making a recovery hard with adequate effects. In this study, we prepared complex nano-iron sulfide integrated erythrocyte-templated nanozyme (ETN) (ETN@Fe7S8) for comprehensive treatment wounds. Firstly, ETN served as mediator confine iron form Fe7S8 nanocomposite in solvothermal reaction. Secondly, the ETN@Fe7S8 demonstrated bactericidal effects against methicillin-resistant Staphylococcus aureus (MRSA) by releasing ferrous polysulfide induce ferroptosis-like cell death. Thirdly, along exerted anti-inflammatory inhibiting activation NF-κB signaling pathway, while also contributed angiogenesis promoting vascular endothelial growth factor A (VEGFA), initiated phosphorylation-mediated PI3K/AKT master regulatory cascade governing survival, migration, angiogenesis. When employed wound, showed ability prevent infection, reduce inflammation, angiogenesis, enhance remodel keratinocytes. Along hemostatic effect, thus performed whole stages. Therefore, our findings provide multifunctional candidate which is capable regulating healing.

Language: Английский

Citations

0
Efficacy of Intravenous Immunoglobulins and Other Immunotherapies in Neurological Disorders and Immunological Mechanisms Involved DOI Creative Commons
Angel A Justiz-Vaillant,

Sachin Soodeen,

Odalis Asin-Milan

et al.

Immuno, Journal Year: 2025, Volume and Issue: 5(2), P. 18 - 18

Published: May 26, 2025

This review aims to explore the role of immunotherapeutic strategies—primarily intravenous immunoglobulin (IVIG), plasma exchange (PLEX), and selected immunomodulatory agents—in treatment neurological psychiatric disorders with suspected or confirmed autoimmune mechanisms. A central focus is placed on understanding immunopathology these conditions through identification characterization disease-associated autoantibodies. Disorders such as encephalitis, myasthenia gravis, limbic epilepsy, neuropsychiatric systemic lupus erythematosus (NPSLE), certain forms schizophrenia have shown clinical responses immunotherapy, suggesting an underlying basis in a subset patients. The also highlights diagnostic relevance detecting autoantibodies targeting neuronal receptors, NMDA AMPA neuromuscular junction components, biomarkers that guide therapeutic decisions. Furthermore, we synthesize findings from published randomized controlled trials (RCTs) validated efficacy IVIG PLEX specific diseases, Guillain–Barré syndrome, gravis. Emerging evidence supports expanding treatments other where autoimmunity implicated. By integrating immunological insights trial data, this offers comprehensive perspective how immunotherapies may be tailored target contributors disease.

Language: Английский

Citations

0