The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study DOI Open Access
Eva Zikou, Nikolas Dovrolis, Charilaos Dimosthenopoulos

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4663 - 4663

Published: Nov. 3, 2023

The role of probiotic supplementation in type 2 diabetes (T2D) treatment is controversial. present study aimed to assess the effects a multi-strain supplement (LactoLevureR (containing Lactobacillus acidophilus, plantarum, Bifidobacterium lactis, and Saccharomyces boulardii)) over 6 months, primarily on glycemic control as well lipid levels alterations gut microbiome, among individuals with T2D residing Greece. A total 91 adults (mean age [±SD] 65.12 ± 10.92 years, 62.6% males) were randomized receive or matching placebo capsule, once daily, for months. Blood chemistries anthropometric parameters conducted every 3 stool samples collected at baseline Significant reductions HbA1c, fasting blood glucose, cholesterol observed participants treated (n = 46) compared controls 45), even after adjustment greater decrease adiposity (waist circumference). Although there no statistically significant differences diversity microbiome (α β diversity), administration probiotics did influence several genera, metabolites, key enzymes associated diabetes. Overall, LactoLevureR 6-month period was well-tolerated had positive impact metabolic parameters, alongside improvements indices adiposity.

Language: Английский

Role of Lactic Acid Bacteria in Food Preservation and Safety DOI Creative Commons
Agnieszka Zapaśnik, Barbara Sokołowska, Marcin Bryła

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(9), P. 1283 - 1283

Published: April 28, 2022

Fermentation of various food stuffs by lactic acid bacteria is one the oldest forms biopreservation. Bacterial antagonism has been recognized for over a century, but in recent years, this phenomenon received more scientific attention, particularly use strains (LAB). Certain LAB demonstrated antimicrobial activity against foodborne pathogens, including bacteria, yeast and filamentous fungi. Furthermore, many authors proved that have ability to neutralize mycotoxin produced last group. Antimicrobial mainly based on production metabolites such as acid, organic acids, hydroperoxide bacteriocins. In addition, some research suggests other mechanisms pathogens well their toxic metabolites. These properties are very important because future possibility exchange chemical physical methods preservation with biological method Biopreservation defined extension shelf life increase safety controlled microorganisms or This may determine alternative usage preservatives. study, possibilities provided. Our aim yield knowledge about fermentation pathogenic microorganisms. we would like introduce actual information health aspects associated consumption fermented products, probiotics.

Language: Английский

Citations

176

Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation DOI Creative Commons
Abdul Raheem,

Lin Liang,

Guangzhi Zhang

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: April 8, 2021

In order to inhibit pathogenic complications and enhance animal poultry growth, antibiotics have been extensively used for many years. Antibiotics applications not only affect target pathogens but also intestinal beneficially microbes, inducing long-lasting changes in microbiota associated with diseases. The application of has other side effects like, barrier dysfunction, residues foodstuffs, nephropathy, allergy, bone marrow toxicity, mutagenicity, reproductive disorders, hepatotoxicity carcinogenicity, antibiotic-resistant bacteria, which greatly compromise the efficacy antibiotics. Thus, development new is necessary, while search antibiotic alternatives continues. Probiotics are considered ideal substitute; recent years, probiotic research concerning their during infections humans, aquaculture, poultry, livestock industry, emphasis on modulating immune system host, attracting considerable interest. Hence, adverse remedial probiotics infectious diseases become central points focus among researchers. live microorganisms, when given adequate quantities, confer good health host through different mechanisms. Among them, regulation response one most important A number studies investigated aspects probiotics. this review, we mainly summarize discoveries discuss two aspects: (1) infections; (2) modulatory non-infectious

Language: Английский

Citations

166

Pediococcus pentosaceus, a future additive or probiotic candidate DOI Creative Commons

Shiman Jiang,

Lingzhi Cai,

Longxian Lv

et al.

Microbial Cell Factories, Journal Year: 2021, Volume and Issue: 20(1)

Published: Feb. 16, 2021

Abstract Background Pediococcus pentosaceus , a promising strain of lactic acid bacteria (LAB), is gradually attracting attention, leading to rapid increase in experimental research. Due increased demand for practical applications microbes, the functional and harmless P. might be worthwhile LAB both food industry biological applications. Results As an additive, improves taste nutrition food, as well storage animal products. Moreover, antimicrobial abilities strains are being highlighted. Evidence suggests that bacteriocins or bacteriocin-like substances (BLISs) produced by play effective antibacterial roles microbial ecosystem. In addition, various have been highlighted probiotic use due their anti-inflammation, anticancer, antioxidant, detoxification, lipid-lowering abilities. Conclusions Therefore, it necessary continue studying further use. Thorough study several should clarify benefits drawbacks future.

Language: Английский

Citations

147

Functional Foods, Nutraceuticals and Probiotics: A Focus on Human Health DOI Creative Commons
Morayma Ramírez Damián, Naima G. Cortes‐Perez,

Erika T. Quintana

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(5), P. 1065 - 1065

Published: May 21, 2022

Functional foods are classified as traditional or staple that provide an essential nutritional level and share potentially positive effects on host health, including the reduction of disease by optimizing immune system's ability to prevent control infections pathogens, well pathologies cause functional alterations in host. This chapter reviews most recent research advances this area discusses some perspectives what future holds area.

Language: Английский

Citations

118

Encapsulation of probiotics: past, present and future DOI Creative Commons

R. Rajam,

Parthasarathi Subramanian

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2022, Volume and Issue: 11(1)

Published: April 5, 2022

Abstract Background Probiotics are live microbial supplements known for its health benefits. Consumption of probiotics reported to improve several benefits including intestinal flora composition, resistance against pathogens. In the recent years, there is an increasing trend probiotic-based food products in market. Main body cells targeted reach large intestine, and must survive through acidic conditions gastric environment. It recommended formulate probiotic bacteria range 10 8 –10 9 cfu/g consumption maintain therapeutic efficacy 6 7 intestine. During gastrointestinal transit, will drastically lose viability environment (pH 2). Maintaining cell until it reaches intestine remains challenging task. Encapsulating with suitable wall material helps sustain survival during industrial processing transit. encapsulation process, completely enclosed material, different techniques spray drying, freeze extrusion, emulsification, etc. However, spray-drying freeze-drying successfully used commercial formulation; thus, we limited review those techniques. Short conclusions The rate spray-dried simulated digestion mainly depends on inlet air temperature, exposure GI condition. And fermentation, pH time important process parameters maintaining bacterial Improving extending storage be main concern successful commercialization. Graphical abstract

Language: Английский

Citations

95

About Functional Foods: The Probiotics and Prebiotics State of Art DOI Creative Commons
Andrea Ballini, Ioannis Alexandros Charitos, Stefania Cantore

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(4), P. 635 - 635

Published: March 23, 2023

Poor diet, obesity and a sedentary lifestyle have significant impact on natural microbiota disorders; specifically, the intestinal one. This in turn can lead to multitude of organ dysfunctions. The gut contains more than 500 species bacteria constitutes 95% total number cells human body, thus contributing significantly host’s resistance infectious diseases. Nowadays, consumers turned purchased foods, especially those containing probiotic or prebiotics, that constitute some functional food market, which is constantly expanding. Indeed, there are many products available incorporate probiotics, such as yogurt, cheese, juices, jams, cookies, salami sausages, mayonnaise, nutritional supplements, etc. probiotics microorganisms that, when taken sufficient amounts, contribute positively health host focus interest for both scientific studies commercial companies. Thus, last decade, introduction DNA sequencing technologies with subsequent bioinformatics processing contributes in-depth characterization vast biodiversity microbiota, their composition, connection physiological function—known homeostasis—of organism, involvement several Therefore, this study, we highlighted extensive investigation current research association types foods prebiotics diet composition microbiota. As result, study form foundation new path based reliable data from literature, acting guide continuous effort monitor rapid developments field.

Language: Английский

Citations

73

A comprehensive review on the utilization of probiotics in aquaculture towards sustainable shrimp farming DOI

C M Mathan Muthu,

A.S. Vickram,

B. Bhavani Sowndharya

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 147, P. 109459 - 109459

Published: Feb. 17, 2024

Language: Английский

Citations

23

Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects DOI Creative Commons
Abdul Bari Shah, Aizhamal Baiseitova, Muhammad Zahoor

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 24, 2024

A rising corpus of research has shown the beneficial effects probiotic

Language: Английский

Citations

19

Role of Probiotics against Human Cancers, Inflammatory Diseases, and Other Complex Malignancies DOI Open Access
Hammad Naeem,

Hammad Ul Hassan,

Muhammad Shahbaz

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 23

Published: Feb. 7, 2024

Probiotics have growing medical importance as a result of their potential in the prevention and therapeutic support several complex diseases, including different types cancers. The anticarcinogenic properties probiotics are attributed to various mechanisms, alterations composition intestinal microbiota, suppression cell proliferation, stimulation apoptosis, inhibition NF-kB, reduction levels H2AX, 8-hydroxy-deoxyguanosine, RIG-I, downregulation IL-17, TNF signaling pathway. Furthermore, demonstrated significant advantages management other diabetes, obesity, cardiovascular diseases. had considerable effect reducing inflammatory infiltration occurrence precancerous lesions. Additionally, administration led decrease appearance level genes related proinflammatory pathways, NF-κB, pathways. However, further research studies required comprehend processes via which exert effects authenticate alternative interventions.

Language: Английский

Citations

17

Impact of Microbial Metabolites on Microbiota–Gut–Brain Axis in Inflammatory Bowel Disease DOI Open Access

Davide Banfi,

Elisabetta Moro, Annalisa Bosi

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(4), P. 1623 - 1623

Published: Feb. 5, 2021

The complex bidirectional communication system existing between the gastrointestinal tract and brain initially termed “gut–brain axis” renamed “microbiota–gut–brain axis”, considering pivotal role of gut microbiota in sustaining local systemic homeostasis, has a fundamental pathogenesis Inflammatory Bowel Disease (IBD). integration signals deriving from host neuronal, immune, endocrine systems with may influence development inflammatory injury impacts also more distal regions, underlying psychophysiological vulnerability IBD patients. Mood disorders increased response to stress are frequently associated affect disease recurrence severity, thus requiring an appropriate therapeutic approach addition conventional anti-inflammatory treatments. This review highlights recent evidence suggesting that alterations microbiota–gut–brain axis concur sustain both CNS symptoms. participation main microbial-derived metabolites, defined as “postbiotics”, such bile acids, short-chain fatty tryptophan metabolites IBD-associated dysfunction will be discussed. last section covers critical evaluation clinical pointing microbiome-based approaches for treatment IBD-related neuropsychiatric

Language: Английский

Citations

101