Nutrients,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4663 - 4663
Published: Nov. 3, 2023
The
role
of
probiotic
supplementation
in
type
2
diabetes
(T2D)
treatment
is
controversial.
present
study
aimed
to
assess
the
effects
a
multi-strain
supplement
(LactoLevureR
(containing
Lactobacillus
acidophilus,
plantarum,
Bifidobacterium
lactis,
and
Saccharomyces
boulardii))
over
6
months,
primarily
on
glycemic
control
as
well
lipid
levels
alterations
gut
microbiome,
among
individuals
with
T2D
residing
Greece.
A
total
91
adults
(mean
age
[±SD]
65.12
±
10.92
years,
62.6%
males)
were
randomized
receive
or
matching
placebo
capsule,
once
daily,
for
months.
Blood
chemistries
anthropometric
parameters
conducted
every
3
stool
samples
collected
at
baseline
Significant
reductions
HbA1c,
fasting
blood
glucose,
cholesterol
observed
participants
treated
(n
=
46)
compared
controls
45),
even
after
adjustment
greater
decrease
adiposity
(waist
circumference).
Although
there
no
statistically
significant
differences
diversity
microbiome
(α
β
diversity),
administration
probiotics
did
influence
several
genera,
metabolites,
key
enzymes
associated
diabetes.
Overall,
LactoLevureR
6-month
period
was
well-tolerated
had
positive
impact
metabolic
parameters,
alongside
improvements
indices
adiposity.
Foods,
Journal Year:
2022,
Volume and Issue:
11(9), P. 1283 - 1283
Published: April 28, 2022
Fermentation
of
various
food
stuffs
by
lactic
acid
bacteria
is
one
the
oldest
forms
biopreservation.
Bacterial
antagonism
has
been
recognized
for
over
a
century,
but
in
recent
years,
this
phenomenon
received
more
scientific
attention,
particularly
use
strains
(LAB).
Certain
LAB
demonstrated
antimicrobial
activity
against
foodborne
pathogens,
including
bacteria,
yeast
and
filamentous
fungi.
Furthermore,
many
authors
proved
that
have
ability
to
neutralize
mycotoxin
produced
last
group.
Antimicrobial
mainly
based
on
production
metabolites
such
as
acid,
organic
acids,
hydroperoxide
bacteriocins.
In
addition,
some
research
suggests
other
mechanisms
pathogens
well
their
toxic
metabolites.
These
properties
are
very
important
because
future
possibility
exchange
chemical
physical
methods
preservation
with
biological
method
Biopreservation
defined
extension
shelf
life
increase
safety
controlled
microorganisms
or
This
may
determine
alternative
usage
preservatives.
study,
possibilities
provided.
Our
aim
yield
knowledge
about
fermentation
pathogenic
microorganisms.
we
would
like
introduce
actual
information
health
aspects
associated
consumption
fermented
products,
probiotics.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: April 8, 2021
In
order
to
inhibit
pathogenic
complications
and
enhance
animal
poultry
growth,
antibiotics
have
been
extensively
used
for
many
years.
Antibiotics
applications
not
only
affect
target
pathogens
but
also
intestinal
beneficially
microbes,
inducing
long-lasting
changes
in
microbiota
associated
with
diseases.
The
application
of
has
other
side
effects
like,
barrier
dysfunction,
residues
foodstuffs,
nephropathy,
allergy,
bone
marrow
toxicity,
mutagenicity,
reproductive
disorders,
hepatotoxicity
carcinogenicity,
antibiotic-resistant
bacteria,
which
greatly
compromise
the
efficacy
antibiotics.
Thus,
development
new
is
necessary,
while
search
antibiotic
alternatives
continues.
Probiotics
are
considered
ideal
substitute;
recent
years,
probiotic
research
concerning
their
during
infections
humans,
aquaculture,
poultry,
livestock
industry,
emphasis
on
modulating
immune
system
host,
attracting
considerable
interest.
Hence,
adverse
remedial
probiotics
infectious
diseases
become
central
points
focus
among
researchers.
live
microorganisms,
when
given
adequate
quantities,
confer
good
health
host
through
different
mechanisms.
Among
them,
regulation
response
one
most
important
A
number
studies
investigated
aspects
probiotics.
this
review,
we
mainly
summarize
discoveries
discuss
two
aspects:
(1)
infections;
(2)
modulatory
non-infectious
Microbial Cell Factories,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Feb. 16, 2021
Abstract
Background
Pediococcus
pentosaceus
,
a
promising
strain
of
lactic
acid
bacteria
(LAB),
is
gradually
attracting
attention,
leading
to
rapid
increase
in
experimental
research.
Due
increased
demand
for
practical
applications
microbes,
the
functional
and
harmless
P.
might
be
worthwhile
LAB
both
food
industry
biological
applications.
Results
As
an
additive,
improves
taste
nutrition
food,
as
well
storage
animal
products.
Moreover,
antimicrobial
abilities
strains
are
being
highlighted.
Evidence
suggests
that
bacteriocins
or
bacteriocin-like
substances
(BLISs)
produced
by
play
effective
antibacterial
roles
microbial
ecosystem.
In
addition,
various
have
been
highlighted
probiotic
use
due
their
anti-inflammation,
anticancer,
antioxidant,
detoxification,
lipid-lowering
abilities.
Conclusions
Therefore,
it
necessary
continue
studying
further
use.
Thorough
study
several
should
clarify
benefits
drawbacks
future.
Microorganisms,
Journal Year:
2022,
Volume and Issue:
10(5), P. 1065 - 1065
Published: May 21, 2022
Functional
foods
are
classified
as
traditional
or
staple
that
provide
an
essential
nutritional
level
and
share
potentially
positive
effects
on
host
health,
including
the
reduction
of
disease
by
optimizing
immune
system's
ability
to
prevent
control
infections
pathogens,
well
pathologies
cause
functional
alterations
in
host.
This
chapter
reviews
most
recent
research
advances
this
area
discusses
some
perspectives
what
future
holds
area.
Beni-Suef University Journal of Basic and Applied Sciences,
Journal Year:
2022,
Volume and Issue:
11(1)
Published: April 5, 2022
Abstract
Background
Probiotics
are
live
microbial
supplements
known
for
its
health
benefits.
Consumption
of
probiotics
reported
to
improve
several
benefits
including
intestinal
flora
composition,
resistance
against
pathogens.
In
the
recent
years,
there
is
an
increasing
trend
probiotic-based
food
products
in
market.
Main
body
cells
targeted
reach
large
intestine,
and
must
survive
through
acidic
conditions
gastric
environment.
It
recommended
formulate
probiotic
bacteria
range
10
8
–10
9
cfu/g
consumption
maintain
therapeutic
efficacy
6
7
intestine.
During
gastrointestinal
transit,
will
drastically
lose
viability
environment
(pH
2).
Maintaining
cell
until
it
reaches
intestine
remains
challenging
task.
Encapsulating
with
suitable
wall
material
helps
sustain
survival
during
industrial
processing
transit.
encapsulation
process,
completely
enclosed
material,
different
techniques
spray
drying,
freeze
extrusion,
emulsification,
etc.
However,
spray-drying
freeze-drying
successfully
used
commercial
formulation;
thus,
we
limited
review
those
techniques.
Short
conclusions
The
rate
spray-dried
simulated
digestion
mainly
depends
on
inlet
air
temperature,
exposure
GI
condition.
And
fermentation,
pH
time
important
process
parameters
maintaining
bacterial
Improving
extending
storage
be
main
concern
successful
commercialization.
Graphical
abstract
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(4), P. 635 - 635
Published: March 23, 2023
Poor
diet,
obesity
and
a
sedentary
lifestyle
have
significant
impact
on
natural
microbiota
disorders;
specifically,
the
intestinal
one.
This
in
turn
can
lead
to
multitude
of
organ
dysfunctions.
The
gut
contains
more
than
500
species
bacteria
constitutes
95%
total
number
cells
human
body,
thus
contributing
significantly
host’s
resistance
infectious
diseases.
Nowadays,
consumers
turned
purchased
foods,
especially
those
containing
probiotic
or
prebiotics,
that
constitute
some
functional
food
market,
which
is
constantly
expanding.
Indeed,
there
are
many
products
available
incorporate
probiotics,
such
as
yogurt,
cheese,
juices,
jams,
cookies,
salami
sausages,
mayonnaise,
nutritional
supplements,
etc.
probiotics
microorganisms
that,
when
taken
sufficient
amounts,
contribute
positively
health
host
focus
interest
for
both
scientific
studies
commercial
companies.
Thus,
last
decade,
introduction
DNA
sequencing
technologies
with
subsequent
bioinformatics
processing
contributes
in-depth
characterization
vast
biodiversity
microbiota,
their
composition,
connection
physiological
function—known
homeostasis—of
organism,
involvement
several
Therefore,
this
study,
we
highlighted
extensive
investigation
current
research
association
types
foods
prebiotics
diet
composition
microbiota.
As
result,
study
form
foundation
new
path
based
reliable
data
from
literature,
acting
guide
continuous
effort
monitor
rapid
developments
field.
Journal of Food Biochemistry,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 23
Published: Feb. 7, 2024
Probiotics
have
growing
medical
importance
as
a
result
of
their
potential
in
the
prevention
and
therapeutic
support
several
complex
diseases,
including
different
types
cancers.
The
anticarcinogenic
properties
probiotics
are
attributed
to
various
mechanisms,
alterations
composition
intestinal
microbiota,
suppression
cell
proliferation,
stimulation
apoptosis,
inhibition
NF-kB,
reduction
levels
H2AX,
8-hydroxy-deoxyguanosine,
RIG-I,
downregulation
IL-17,
TNF
signaling
pathway.
Furthermore,
demonstrated
significant
advantages
management
other
diabetes,
obesity,
cardiovascular
diseases.
had
considerable
effect
reducing
inflammatory
infiltration
occurrence
precancerous
lesions.
Additionally,
administration
led
decrease
appearance
level
genes
related
proinflammatory
pathways,
NF-κB,
pathways.
However,
further
research
studies
required
comprehend
processes
via
which
exert
effects
authenticate
alternative
interventions.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(4), P. 1623 - 1623
Published: Feb. 5, 2021
The
complex
bidirectional
communication
system
existing
between
the
gastrointestinal
tract
and
brain
initially
termed
“gut–brain
axis”
renamed
“microbiota–gut–brain
axis”,
considering
pivotal
role
of
gut
microbiota
in
sustaining
local
systemic
homeostasis,
has
a
fundamental
pathogenesis
Inflammatory
Bowel
Disease
(IBD).
integration
signals
deriving
from
host
neuronal,
immune,
endocrine
systems
with
may
influence
development
inflammatory
injury
impacts
also
more
distal
regions,
underlying
psychophysiological
vulnerability
IBD
patients.
Mood
disorders
increased
response
to
stress
are
frequently
associated
affect
disease
recurrence
severity,
thus
requiring
an
appropriate
therapeutic
approach
addition
conventional
anti-inflammatory
treatments.
This
review
highlights
recent
evidence
suggesting
that
alterations
microbiota–gut–brain
axis
concur
sustain
both
CNS
symptoms.
participation
main
microbial-derived
metabolites,
defined
as
“postbiotics”,
such
bile
acids,
short-chain
fatty
tryptophan
metabolites
IBD-associated
dysfunction
will
be
discussed.
last
section
covers
critical
evaluation
clinical
pointing
microbiome-based
approaches
for
treatment
IBD-related
neuropsychiatric