Chronic wounds

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: July 21, 2022

Language: Английский

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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Allergy, Journal Year: 2022, Volume and Issue: 77(5), P. 1418 - 1449

Published: Feb. 2, 2022

Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.

Language: Английский

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Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 22, 2022

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and immune system is impaired, subsequent effects can be triggered on skin, potentially promoting development of skin diseases. mechanisms through which affects health are still unclear. Enhancing our understanding connection needed to find novel ways treat disorders. In this review, we systematically evaluate current data regarding ecology healthy gut, diet, pre- probiotics, antibiotics, their health. We discuss potential axis link skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa. This review will increase impacts conditions aid finding new medications for

Language: Английский

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Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota

Microorganisms, Journal Year: 2021, Volume and Issue: 9(3), P. 543 - 543

Published: March 5, 2021

The skin is the largest organ of human body and it protects from external environment. It has become topic interest researchers various scientific fields. Microorganisms ensure proper functioning skin. Of great importance, are mutual relations between such microorganisms their responses to environmental impacts, as dysbiosis may contribute serious diseases. Molecular methods, used for microorganism identification, allow us gain a better understanding microbiome. presented article contains latest reports on microbiota in health disease. review discusses relationship properly microbiome body’s immune system, well impact internal factors

Language: Английский

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Microbiota medicine: towards clinical revolution

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 7, 2022

Abstract The human gastrointestinal tract is inhabited by the largest microbial community within body consisting of trillions microbes called gut microbiota. normal flora site many physiological functions such as enhancing host immunity, participating in nutrient absorption and protecting against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between microbiota organs intestines, lungs, brain, skin. Large evidence demonstrated, more than decade ago, that alteration key factor pathogenesis local systemic disorders. In this regard, deep understanding mechanisms involved symbiosis/dysbiosis crucial for clinical health field. We review most recent studies on involvement diseases. also elaborate different strategies used to manipulate prevention treatment future medicine strongly related quality our Targeting dysbiosis will be huge challenge.

Language: Английский

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Oxidative stress in the skin: Impact and related protection

International Journal of Cosmetic Science, Journal Year: 2021, Volume and Issue: 43(5), P. 495 - 509

Published: July 27, 2021

Abstract Skin, our first interface to the external environment, is subjected oxidative stress caused by a variety of factors such as solar ultraviolet, infrared and visible light, environmental pollution, including ozone particulate matters, psychological stress. Excessive reactive species, oxygen species nitrogen exacerbate skin pigmentation aging, which further lead tone unevenness, pigmentary disorder, roughness wrinkles. Besides these, microbiota are also very important factor ensuring proper functions skin. While UV pollutants impact compositions, dysbiosis results in various conditions. In this review, we summarize generation from exogenous endogenous sources. We introduce current knowledge on possible roles specifically with emphasis pigmentation. Meanwhile, science rationale using three well‐known antioxidants, namely vitamin C, resveratrol ferulic acid, treatment hyperpigmentation. Finally, discuss strategy for preventing stress‐induced aging.

Language: Английский

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Skin Barrier Function and the Microbiome

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13071 - 13071

Published: Oct. 28, 2022

Human skin is the largest organ and serves as first line of defense against environmental factors. The human microbiota defined total microbial community that coexists in body, while microbiome refers to collective genome these microorganisms. Skin microbes do not simply reside on but interact with a variety ways, significantly affecting barrier function. Here, we discuss recent insights into symbiotic relationships between physical, chemical, innate/adaptive immunological ways. We gut-skin axis affects Finally, examine effects dysbiosis function role inflammatory diseases, such acne, atopic dermatitis, psoriasis. Microbiome cosmetics can help restore improve diseases.

Language: Английский

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A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154824 - 154824

Published: April 19, 2023

Every day the skin is constantly exposed to several harmful factors that induce oxidative stress. When cells are incapable maintain balance between antioxidant defenses and reactive oxygen species, no longer can keep its integrity homeostasis. Chronic inflammation, premature aging, tissue damage, immunosuppression possible consequences induced by sustained exposure environmental endogenous species. Skin immune non-immune together with microbiome essential efficiently trigger responses For this reason, an ever-increasing demand for novel molecules capable of modulating functions in has risen level their development, particularly field natural product-derived molecules. In review, we explore different classes showed evidence modulate responses, as well target receptors signaling pathways. Moreover, describe role polyphenols, polysaccharides, fatty acids, peptides, probiotics treatments conditions, including wound healing, infection, allergies, aging. Literature was searched, analyzed, collected using databases, PubMed, Science Direct, Google Scholar. The search terms used included "Skin", "wound healing", "natural products", "skin microbiome", "immunomodulation", "anti-inflammatory", "antioxidant", "infection", "UV radiation", "polyphenols", "polysaccharides", "fatty acids", "plant oils", "peptides", "antimicrobial peptides", "probiotics", "atopic dermatitis", "psoriasis", "auto-immunity", "dry skin", "aging", etc., combinations these keywords. Natural products offer solutions conditions. Significant anti-inflammatory activities were reported, followed ability skin. Several membrane-bound recognize diverse types natural-derived molecules, promoting improve Despite increasing progress drug discovery, limiting need future clarification. Understanding safety, biological activities, precise mechanisms action a priority characterization active compounds responsible that. This review provides directions studies development new important pharmaceutical cosmeceutical value.

Language: Английский

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The Human Skin Microbiome in Selected Cutaneous Diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: March 7, 2022

The human skin harbors a wide variety of microbes that, together with their genetic information and host interactions, form the microbiome. role microbiome in development various diseases has lately gained interest. According to several studies, changes cutaneous microbiota are involved pathophysiology dermatoses. A better delineation its interactions innate adaptive immune systems could lead understanding these diseases, as well opportunity achieve new therapeutic modalities. present review centers on most recent knowledge participation pathogenesis disorders: atopic seborrheic dermatitis, alopecia areata, psoriasis acne.

Language: Английский

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Topical Probiotics: More Than a Skin Deep

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 557 - 557

Published: March 3, 2022

Skin, an exterior interface of the human body is home to commensal microbiota and also acts a physical barrier that protects from invasion foreign pathogenic microorganisms. In recent years, interest has significantly expanded beyond gut microbiome include skin its influence in managing several disorders. Probiotics play major role maintaining health disease prevention. Topical probiotics have demonstrated beneficial effects for treatment certain inflammatory diseases such as acne, rosacea, psoriasis etc., found promising wound healing. this review, we discuss insights into applications topical their on skin. Patents, commercially available probiotics, novel probiotic impregnated fabrics been emphasized. A thorough understanding relationship between important designing therapeutic approaches using probiotics.

Language: Английский

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