Correlation Analysis Between the Growth of Wild-Simulated Ginseng and the Soil Bacterial Community in the Central Region of South Korea DOI Creative Commons

Kiyoon Kim,

Yeong-Bae Yun, Mi Jin Park

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(7), P. 3465 - 3465

Published: March 21, 2025

Wild-simulated ginseng (WSG, Panax C.A. Meyer) is the most important medicinal plant naturally cultivated in forestry environment. The growth and active component content of WSG can be influenced by various environmental factors, such as climate conditions, physiognomy, soil properties, bacterial structure. aim this study was to investigate relationship between characteristics community living a rhizosphere Experimental subjects were 7- 13-year-old central region (Yeongju) Korea. WSG, divided into aerial parts, root weight measured. Rhizome length significantly higher for while number rootlets 7-year-old WSG. As result analyzing communities cultivation sites using next-generation sequencing (NGS), Proteobacteria Holophagae found dominant species phylum level class level, respectively. positively correlated with Bacteroidetes at but it negatively Thermoleophilia Gemmatimonadetes level. Pedospharae showed negative correlation leaflets petiole length, Clostridia positive rootlets. might vary depending on environment which cultivated. It especially affected properties communities. Therefore, future studies, will necessary isolate identify microorganisms then confirm their growth-promoting effects

Language: Английский

Natural Anticancer Agents: Their Therapeutic Potential, Challenges and Promising Outcomes DOI
Savita Tauro, Bharat Dhokchawle, Popat Mohite

et al.

Current Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 31(7), P. 848 - 870

Published: May 4, 2023

Cancer, the second leading cause of death worldwide, is a major health problem. Chemotherapy, radiation therapy and surgery are current treatments for cancer. Most anticancer drugs have severe toxic effects required to be administered in cycles reduce toxicity prevent resistance. Plant-based shown potential treatment cancer, various plant secondary metabolites promising antitumor activity against several cancer cell lines, such as leukemia, colon prostate breast lung Vincristine, etoposide, topotecan paclitaxel, which natural origin, successfully used clinical practice, this has generated interest compounds agents. Some phytoconstituents like curcumin, piperine, allicin, quercetin resveratrol been extensively researched reviewed. In study, we reviewed plants Athyrium hohenackerianum, Aristolochia baetica, Boswellia serrata, Panax ginseng, Berberis vulgaris, Tanacetum parthenium, Glycine max, Combretum fragrans, Persea americana, Raphanus sativus, Camellia sinensis, Nigella sativa their source, key phytoconstituents, along with profile. Few boswellic acid, sulforaphane ginsenoside showed excellent compared standard candidates.

Language: Английский

Citations

14
Genome-wide identification and integrated analysis of TCP genes controlling ginsenoside biosynthesis in Panax ginseng DOI Creative Commons
Chang Liu, Tingting Lv,

Yanhua Shen

et al.

BMC Plant Biology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 13, 2024

Abstract Panax ginseng is an important medicinal plant, and ginsenosides are the main bioactive molecules of ginseng. The TCP (TBI, CYC, PCF) family a group transcription factors (TFs) that play role in plant growth development, hormone signalling synthesis secondary metabolites. In our study, 78 PgTCP transcripts were identified from established transcriptome database. A phylogenetic tree analysis showed 67 with complete open reading frames classified into three subfamilies, including CIN, PCF, CYC/TB1. Protein structure genes had bHLH structures. Chromosomal localization 63 localized on 17 24 chromosomes Chinese genome. Expression pattern differed among different lineages spatiotemporally specific. Coexpression network indicated coexpressed involved activities or metabolic regulation expression levels class I (PCF) significantly downregulated, while II (CIN CYC/TB1) upregulated, suggesting may be metabolism As PgTCP26-02 gene was found to related ginsenoside synthesis, its predicted protein further analysed. Our results provide new insights origin, differentiation, evolution function ginseng, as well metabolism.

Language: Английский

Citations

5
Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications DOI
Lei Wu, Lin Bai, Wenshu Dai

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(10), P. 869 - 884

Published: March 5, 2024

Background: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as complementary therapy for cancer. A promising natural compound extracted from the herb ginseng ginsenoside Rg3, which demonstrated significant anticancer effects. It been tested in variety cancers tumors proven to be effective suppressing Objective: This work covers aspects role Rg3 cancer treatment, including its biological functions, key pathways, epigenetics, potential combination therapies, all have extensively researched elucidated. The study aims provide reference future research on an agent support application treatment.

Language: Английский

Citations

5
A systemic review of ginseng and its activity on coronary heart disease DOI Creative Commons
Shivam Alpeshkumar Parmar, Vinyas Mayasa, Vinod K. Nelson

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100480 - 100480

Published: July 14, 2024

Coronary heart disease (CHD) is a leading cause of mortality and morbidity globally, highlighting the need for effective therapeutic strategies. This systematic review evaluates cardioprotective mechanisms ginseng its potential as complementary or adjunctive therapy in prevention management CHD. A literature search was conducted major databases (SCOPUS, PubMed, Google Scholar) following PRISMA guidelines to identify relevant preclinical clinical studies investigating ginseng's effects on CHD associated cardiovascular conditions. Studies reporting positive outcomes related properties active compounds were included analysis. Ginseng bioactive constituents, especially ginsenosides, exhibit diverse CHD, including vasodilation, hypotensive, antioxidant, anti-hyperlipidemic effects, anti- atherosclerotic, antithrombotic, anti-inflammatory various other molecular mechanism proven by that demonstrates can mitigates myocardial ischemia, improves cardiac contractility, regulates blood pressure, lipid profiles, thrombus formation glycemic control. represents promising natural due well-established safety profile targeting multiple pathways involved pathophysiology. Although, more robust evidence needed. Integrating into conventional treatment regimens, guided scientific research, could enhance improve patient outcomes.

Language: Английский

Citations

5
Complex transcriptome network regulates the anthocyanin accumulation of four Panax ginseng cultivars in fruit DOI Creative Commons
Jaewook Kim, Bae Young Choi, Donghwan Shim

et al.

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biosynthesis, therapeutic characteristics, origin and strategies to improve the yield of vasicine in plants DOI
Deepthi Padmanabhan, R. Manimekalai, Sengottayan Senthil‐Nathan

et al.

Vegetos, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Bacterial endophytes from ginseng and their biotechnological application DOI Creative Commons
Luan Luong Chu, Hanhong Bae

Journal of Ginseng Research, Journal Year: 2021, Volume and Issue: 46(1), P. 1 - 10

Published: April 19, 2021

Ginseng has been well-known as a medicinal plant for thousands of years. Bacterial endophytes ubiquitously colonize the inside tissues ginseng without any disease symptoms. The identification bacterial is conducted through either internal transcribed spacer region combined with ribosomal sequences or metagenomics. endophyte communities differ in their diversity and composition profile, depending on geographical location, cultivation condition, tissue, age, species ginseng. have significant effect growth indole-3-acetic acid (IAA) siderophore production, phosphate solubilization, nitrogen fixation. Moreover, can protect by acting biocontrol agents. Interestingly, isolated from

Language: Английский

Citations

32
Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation DOI Open Access
Xiaodan Sun, Ying Cheng

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113912 - 113912

Published: Oct. 23, 2022

Ginsenoside Rh2 (Rh2), the major bio-active ginsenoside that originated from root of Panax ginseng, has become a "hot topic" for playing multifunctional roles in both tumor treatment and microenvironment (TME) immunomodulation. Up to now, emerging experimental research about therapy immuno-regulation been published, however, specific reviews focused on its role TME were limited. Hence, this article, we briefly summarized existing evidence supporting anticancer effects potential mechanisms according type, including anti-proliferation, anti-invasion, metastasis, induction cell cycle arrest, anti-angiogenesis, promotion reactive oxygen species differentiation. Meanwhile, shed light TME, with an emphasis regulating immunogenicity, immune cells, cytokines, physicochemical properties TME. Finally, current limitation prospects discussed.

Language: Английский

Citations

21
Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action DOI Creative Commons

Zhi Chen,

Si-yong Ye

Pharmaceutical Biology, Journal Year: 2022, Volume and Issue: 60(1), P. 1063 - 1076

Published: May 28, 2022

Viruses have the characteristics of rapid transmission and high mortality. At present, western medicines still lack an ideal antiviral. As natural products, many traditional Chinese (TCM) certain inhibitory effects on viruses, which has become hotspot medical research in recent years.The antiviral active ingredients mechanisms TCM against viral diseases was studied combination with pathogenesis effects.English literature from 1999 to 2021 collected databases including Web Science, PubMed, Elsevier, Pharmacopoeia 2020 (CP), CNKI (Chinese). Traditional (TCM), ingredients, antiviral, mechanism action, anti-inflammatory effect were used as key words.The activity is clarified put forward a strategy for discovering compounds provide reference screening antivirus drugs TCM. can not only directly kill viruses inhibit proliferation cells, but also prevent infecting cells causing cytophilia. It regulate human immune system, enhance immunity, play indirect role.Based experimental study TCM, this paper analytical evidence that supports effectiveness treating virus infections, well their viruses. could be helpful development innovative TCMs multiple components, targets low toxicity.

Language: Английский

Citations

20
Genome-wide analysis of Panax MADS-box genes reveals role of PgMADS41 and PgMADS44 in modulation of root development and ginsenoside synthesis DOI

Honghong Jiao,

Zhongyi Hua, Junhui Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123648 - 123648

Published: Feb. 11, 2023

Language: Английский

Citations

12