Mediators of Inflammation,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:Trapa
natans
L.
fruits
and
leaf
extracts
have
a
broad
range
of
immunomodulatory,
anti-inflammatory,
antioxidant
effects;
however,
their
effects
on
cardiac
protection
not
been
investigated.
Objective:
The
study
aims
to
test
the
biological
activity
Trapa
extract
(TNE)
in
cisplatin
(CDDP)-induced
cardiotoxicity.
Methods:
Wistar
albino
rats
received
single
dose
CDDP
intraperitoneally
TNE
ones
per
day
for
2
weeks
orally.
Cardiac
inflammation,
necrosis,
fibrosis
were
determined
by
histological
immunohistochemical
analyses.
Cytokines
rat
sera
tissue
detected
enzyme-linked
immunosorbent
assay
(ELISA)
quantitative
real-time
(qRT)-PCR.
Rat
macrophages
cultured
presence
48
h
harvested
flow
cytometry,
while
supernatants
collected
cytokine
reactive
oxygen
species
(ROS)
measurement.
Results:
Application
significantly
attenuated
induced
cardiotoxicity
as
demonstrated
biochemical
histopathological
analysis.
Administration
once
daily
14
days
decreased
level
proinflammatory
(TNF-α,
IFN-γ,
IL-6)
prooxidative
parameters
(NO2,
O2,
H2O2),
increased
immunosuppressive
IL-10
antioxidative
glutathione
(GSH),
catalase
(CAT)
uperoxide
dismutase
(SOD)
systemic
circulation.
treatment
resulted
heart
inflammation
accompanied
with
reduced
infiltration
expression
profibrotic
genes
CDDP-treated
animals.
In
vitro
lipopolysaccharide
(LPS)-stimulated
adopted
phenotype
characterized
production
cytokines
mediators.
Conclusion:
Our
provides
evidence
that
ameliorates
cisplatin-induced
reducing
oxidative
stress
via
promoting
M2
macrophage
polarization.
Molecules,
Journal Year:
2023,
Volume and Issue:
29(1), P. 31 - 31
Published: Dec. 20, 2023
Chitosan
nanoparticles
(NPs)
serve
as
useful
multidrug
delivery
carriers
in
cancer
chemotherapy.
has
considerable
potential
drug
systems
(DDSs)
for
targeting
tumor
cells.
Doxorubicin
(DOX)
limited
application
due
to
its
resistance
and
lack
of
specificity.
NPs
have
been
used
DOX
because
their
biocompatibility,
biodegradability,
encapsulation
efficiency,
target
In
this
review,
various
types
chitosan
derivatives
are
discussed
DDSs
enhance
the
effectiveness
treatments.
Modified
chitosan–DOX
NP
deliveries
with
other
compounds
also
increase
penetration
efficiency
against
We
highlight
endogenous
stimuli
(pH,
redox,
enzyme)
exogenous
(light,
magnetic,
ultrasound),
positive
effect
on
via
NPs.
Our
study
sheds
light
importance
treatment
may
inspire
development
more
effective
approaches
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 5, 2024
Iron-based
nanozymes,
recognized
for
their
biocompatibility
and
peroxidase-like
activities,
hold
promise
as
catalysts
in
tumor
therapy.
However,
concurrent
catalase-like
activity
undermines
therapeutic
efficacy
by
converting
hydrogen
peroxide
tissues
into
oxygen,
thus
diminishing
hydroxyl
radical
production.
Addressing
this
challenge,
study
introduces
the
hemin–cysteine–Fe
(HCFe)
nanozyme,
which
exhibits
exclusive
activity.
Constructed
through
a
supramolecular
assembly
approach
involving
Fmoc-l-cysteine,
heme,
Fe²⁺
coordination,
HCFe
distinctly
incorporates
heme
[Fe–S]
within
its
active
center.
Sulfur
coordination
to
central
Fe
atom
of
Hemin
is
crucial
modulating
catalytic
preference
nanozyme
towards
This
unique
mechanism
distinguishes
from
other
bifunctional
iron-based
enhancing
selectivity
even
beyond
that
natural
peroxidases.
selective
allows
significantly
elevate
ROS
production
exert
cytotoxic
effects,
especially
against
cisplatin-resistant
esophageal
squamous
cell
carcinoma
(ESCC)
cells
xenografts
female
mice
when
combined
with
cisplatin.
These
findings
underscore
HCFe's
potential
component
multimodal
cancer
therapy,
notably
augmenting
chemotherapy
efficacy.
nanozymes
are
promising
therapy
owing
activity,
but
Here,
authors
address
issue
developing
Mediators of Inflammation,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:Trapa
natans
L.
fruits
and
leaf
extracts
have
a
broad
range
of
immunomodulatory,
anti-inflammatory,
antioxidant
effects;
however,
their
effects
on
cardiac
protection
not
been
investigated.
Objective:
The
study
aims
to
test
the
biological
activity
Trapa
extract
(TNE)
in
cisplatin
(CDDP)-induced
cardiotoxicity.
Methods:
Wistar
albino
rats
received
single
dose
CDDP
intraperitoneally
TNE
ones
per
day
for
2
weeks
orally.
Cardiac
inflammation,
necrosis,
fibrosis
were
determined
by
histological
immunohistochemical
analyses.
Cytokines
rat
sera
tissue
detected
enzyme-linked
immunosorbent
assay
(ELISA)
quantitative
real-time
(qRT)-PCR.
Rat
macrophages
cultured
presence
48
h
harvested
flow
cytometry,
while
supernatants
collected
cytokine
reactive
oxygen
species
(ROS)
measurement.
Results:
Application
significantly
attenuated
induced
cardiotoxicity
as
demonstrated
biochemical
histopathological
analysis.
Administration
once
daily
14
days
decreased
level
proinflammatory
(TNF-α,
IFN-γ,
IL-6)
prooxidative
parameters
(NO2,
O2,
H2O2),
increased
immunosuppressive
IL-10
antioxidative
glutathione
(GSH),
catalase
(CAT)
uperoxide
dismutase
(SOD)
systemic
circulation.
treatment
resulted
heart
inflammation
accompanied
with
reduced
infiltration
expression
profibrotic
genes
CDDP-treated
animals.
In
vitro
lipopolysaccharide
(LPS)-stimulated
adopted
phenotype
characterized
production
cytokines
mediators.
Conclusion:
Our
provides
evidence
that
ameliorates
cisplatin-induced
reducing
oxidative
stress
via
promoting
M2
macrophage
polarization.
