ACS Infectious Diseases,
Journal Year:
2023,
Volume and Issue:
9(10), P. 2048 - 2061
Published: Sept. 29, 2023
Leishmaniases
are
among
the
neglected
tropical
diseases
that
still
cause
devastating
health,
social,
and
economic
consequences
to
more
than
350
million
people
worldwide.
Despite
efforts
combat
these
vector-borne
diseases,
their
incidence
does
not
decrease.
Meanwhile,
current
antileishmanial
drugs
old
highly
toxic,
safer
presentations
unaffordable
most
severely
affected
human
populations.
In
a
previous
study
by
our
research
group,
we
synthesized
17
flavonoid
derivatives
demonstrated
impressive
inhibition
capacity
against
rCPB2.8,
rCPB3,
rH84Y.
These
cysteine
proteases
expressed
in
amastigote
stage,
target
form
of
parasite.
However,
although
compounds
have
been
already
described
literature,
until
now,
effect
any
molecules
has
proven.
this
work,
aimed
deeply
analyze
action
set
synthetic
correlating
ability
inhibit
with
Among
all
derivatives,
11
them
showed
high
activity
amastigotes
Leishmania
amazonensis,
also
providing
safety
mammalian
host
cells.
Furthermore,
production
nitric
oxide
infected
cells
treated
active
protease
B
(CPB)
inhibitors
confirms
potential
immunomodulatory
response
macrophages.
Besides,
considering
flavonoids
as
multitarget
drugs,
investigated
other
mechanisms.
The
were
selected
investigate
another
biological
pathway
behind
using
flow
cytometry
analysis.
results
confirmed
an
oxidative
stress
after
48
h
treatment.
data
represent
important
step
toward
validation
CPB
target,
well
aiding
new
drug
discovery
studies
based
on
protease.
Current Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
30(21), P. 2421 - 2448
Published: Aug. 2, 2022
Background:
The
chemistry
of
organoselenium
reagents
provides
an
asset
for
organic
synthesis.
versatility
these
as
electrophiles
and
nucleophiles
makes
them
one
the
key
components
Various
synthetic
transformations
such
oxyselenenylations,
selenocyclization
selenoxide
elimination
have
been
successfully
achieved
using
under
mild
reaction
conditions.
presence
selenocysteine
in
a
few
mammalian
enzymes
was
information
selenium
chemists
to
explore
biochemistry
compounds.
Glutathione
peroxidase
(GPx),
selenoenzyme,
is
well
known
maintaining
redox
equilibrium
by
detoxifying
reactive
oxygen
species.
Objective:
aim
critically
analyze
recent
development
prospects
synthesis
antioxidant
properties
Method:
In
this
review,
we
summarised
research
review
papers
from
PubMed
Scopus
databases.
primary
themes
were
linked
compounds
their
capacity
maintain
cellular
when
exposed
oxidative
stress.
Result:
study
reveals
that
diselenide
synthesised
various
methods
showed
better
activity
profile
compared
selenides.
cases,
found
than
standard
compound
ebselen.
Moreover,
Selenium-based
nanoparticles
also
included.
Conclusion:
past
two
decades,
biological
extensively
studied,
including
properties.
This
article
will
give
insight
into
different
types
recently
would
be
helpful
researchers
working
field
medicinal
directing
new
antioxidants.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(21), P. 7349 - 7349
Published: Oct. 30, 2023
Selenium
is
an
essential
trace
element
in
living
organisms,
and
present
selenoenzymes
with
antioxidant
activity,
like
glutathione
peroxidase
(GPx)
thioredoxin
reductase
(TrxR).
The
search
for
small
selenium-containing
molecules
that
mimic
a
strong
field
of
research
organic
medicinal
chemistry.
In
this
review,
we
review
the
synthesis
bioassays
new
known
organoselenium
compounds
covering
last
five
years.
A
detailed
description
synthetic
procedures
performed
vitro
vivo
presented,
highlighting
most
active
each
series.
New Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
47(12), P. 5598 - 5602
Published: Jan. 1, 2023
We
hereby
present
an
original
and
sustainable
synthetic
methodology
for
the
synthesis
of
3-selanyl-isoflavones
from
2-hydroxyphenyl
enaminones
diorganoyl
diselenides.
Inorganic Chemistry,
Journal Year:
2022,
Volume and Issue:
61(23), P. 8729 - 8745
Published: May 31, 2022
Chalcogen-bonding
interactions
have
recently
gained
considerable
attention
in
the
field
of
synthetic
chemistry,
structure,
and
bonding.
Here,
three
organo-spiroselenuranes,
having
a
Se(IV)
center
with
strong
intramolecular
Se···N
chalcogen-bonded
interaction,
been
isolated
by
oxidation
respective
bis(2-benzamide)
selenides
derived
from
an
8-aminoquinoline
ligand.
Further,
synthesized
spiroselenuranes,
when
assayed
for
their
antioxidant
activity,
show
disproportionation
hydrogen
peroxide
into
H2O
O2
first-order
kinetics
respect
to
H2O2
first
time
any
organoselenium
molecules
as
monitored
1H
NMR
spectroscopy.
Electron-donating
5-methylthio-benzamide
ring-substituted
spiroselenurane
disproportionates
at
high
rate
15.6
±
0.4
×
103
μM
min-1
constant
8.57
0.50
10-3
s-1,
whereas
5-methoxy
unsubstituted-benzamide
spiroselenuranes
catalyzed
rates
7.9
0.3
2.9
constants
1.16
0.02
0.325
0.025
respectively.
The
evolved
oxygen
gas
spiroselenurane-catalyzed
disproportion
has
also
confirmed
chromatograph-thermal
conductivity
detector
(GCTCD)
portable
digital
polarographic
dissolved
probe.
Additionally,
exhibit
thiol
peroxidase
activities
reduction
benzenethiol
co-reductant
UV-visible
Next,
bonded
explored
catalysts
iodolactonization
bromination
arenes.
activated
I2
toward
alkenoic
acids
under
base-free
conditions.
Similarly,
efficient
chemo-
regioselective
monobromination
various
arenes
NBS
achieved.
Mechanistic
insight
reactions
77Se
NMR,
mass
spectrometry,
spectroscopy,
single-crystal
X-ray
theoretical
(DFT,
NBO,
AIM)
studies.
It
seems
that
highly
electrophilic
nature
selenium
is
attributed
presence
interaction
vacant
coordination
site
crucial
activation
H2O2,
I2,
NBS.
reaction
tetravalent
would
lead
octahedral-Se(VI)
intermediate,
which
reduced
back
due
thermodynamic
instability
its
highest
state
N-donor
atom.
Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: May 17, 2022
We
report
an
electrochemical
oxidative
intramolecular
cyclization
reaction
between
2-alkynylphenol
derivatives
and
different
diselenides
species
to
generate
a
wide
variety
of
substituted-benzo[b]furans.
Driven
by
the
galvanostatic
electrolysis
assembled
in
undivided
cell,
it
provided
efficient
transformation
into
oxidant-,
base-,
metal-free
conditions
open
system
at
room
temperature.
With
satisfactory
functional
group
compatibility,
products
were
obtained
good
excellent
yields.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 893 - 893
Published: Jan. 16, 2023
Imidazo[1,2-a]pyridines
(IPs)
have
been
studied
regarding
drug
development.
The
objective
of
this
work
was
to
evaluate
the
antileukemic
capacity
IP
derivatives
by
screening
their
ability
as
a
pro-oxidant.
were
synthesized
and
oral
bioavailability
toxicity
analyzed
in
silico.
Redox
performed
on
human
Kasumi,
KG-1,
K562,
Jurkat
leukemia
cells.
derivative
most
responsive
leukemic
cell
selected
for
cytotoxicity,
proliferation,
senescence,
oxidative
stress
assays.
predictive
analysis
showed
possible
effect
reproductive
system,
but
without
mutagenic,
carcinogenic,
or
irritability
effects.
MRK-107
against
K562
cells
compound
that
best
redox
profile.
did
not
induce
death
monocyte
However,
able
decrease
proliferation
increase
senescence
after
48
72
h.
Furthermore,
induced
h,
increasing
lipid
peroxidation
decreasing
reduced
glutathione
(GSH)
contents.
This
study
demonstrated
MRK-107-induced
with
involvement
is
mechanism
action,
addressing
potential
antitumor
chronic
myeloid
leukemia.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(42), P. 39535 - 39545
Published: Oct. 12, 2023
Herein,
we
describe
a
urea
hydrogen
peroxide-mediated
sustainable
protocol
for
the
synthesis
of
selenylated
imidazo[2,1-b]thiazole
by
using
half
molar
equivalent
diorganyl
diselenides
in
ethyl
lactate
as
greener
solvent.
The
reaction
features
high
yields,
easy
performance
on
gram
scale,
metal-free
conditions,
well
applicability
to
imidazopyridine
and
imidazopyrimidine.
ARKIVOC,
Journal Year:
2022,
Volume and Issue:
2023(5), P. 69 - 92
Published: Dec. 1, 2022
Reactive
oxygen
species
(ROS)
are
responsible
for
many
of
civilization's
diseases,
including
cancer,
diabetes,
and
Alzheimer's
disease,
decomposition
products
in
the
food
industry,
deterioration
physicochemical
properties
polymers
nanomaterials.In
recent
years,
several
organoselenium
compounds
have
been
synthesized
used
as
peroxide
scavengers,
which
source
antioxidant
substances.This
review
aims
to
collect
divide
obtained
last
twelve
years
with
activity,
can
prove
helpful
a)
medicine
supplements
preventing
diseases
caused
by
oxidative
stress,
b)
additives
oxidation,
or
c)
materials
industry
Se-containing
nanoparticles
polymers.In
addition,
most
common
methods
determining
GPx-like
activity
presented.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(7), P. 6396 - 6405
Published: Feb. 13, 2025
Dimethoxynaphthalene
peri-diselenide-based
BODIPY
(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
probe
has
been
synthesized.
The
demonstrated
selectivity
and
sensitivity
for
hydrogen
peroxide
(H2O2)
tert-butylhydroperoxide
(t-BuOOH),
hydroxyl
radical
(•OH),
peroxynitrite
ion
(ONOO–)
detection
reversibility
upon
treatment
with
glutathione.
limits
of
the
were
observed
to
be
0.40
μM
H2O2,
0.41
t-BuOOH,
0.95
•OH,
0.46
ONOO–,
respectively.
A
proposed
mechanism
"turn-on"
event
suggested
corroborated
by
spectroscopic
computational
data.
It
that
electron
transfer
occurred
from
Se
center
moiety,
followed
photoinduced
(PET)
mechanism.