Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy DOI Creative Commons
Duoyang Fan, Xiaohui Liu, Yueming Ren

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(4), P. 1759 - 1771

Published: Dec. 30, 2023

Bacterial biofilm-associated infection was one of the most serious threats to human health. However, effective drugs for drug-resistance bacteria or biofilms remain rarely reported. Here, we propose an innovative strategy develop a multifunctional antimicrobial agent with broad-spectrum antibacterial activity by coupling photosensitizers (PSs) peptides (AMPs). This capitalizes on ability PSs generate reactive oxygen species (ROS) and membrane-targeting property AMPs (KRWWKWIRW, peptide screened artificial neural network), synergistically enhancing activity. In addition, unlike conventional aggregation-caused quenching (ACQ) photosensitizers, aggregation-induced emission (AIE) show stronger fluorescence in aggregated state help visualize mechanism. vitro experiments demonstrated excellent killing effects developed against both Gram-positive (G+) Gram-negative (G–) bacteria. The bacterial-aggregations induced enhanced photoactivatable G– Notably, it exhibited significant effect destroying MRSA biofilms. Moreover, also showed remarkable efficacy treating wound infections mice vivo. holds potential addressing challenges posed bacterial drug-resistant

Language: Английский

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies DOI Creative Commons
Jessica Ceramella, Domenico Iacopetta, Alessia Catalano

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 191 - 191

Published: Feb. 1, 2022

Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers the fixation of CO

Language: Английский

Citations

253
Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review DOI Open Access
Ankita Parmanik, Soumyajit Das, Biswakanth Kar

et al.

Current Microbiology, Journal Year: 2022, Volume and Issue: 79(12)

Published: Nov. 3, 2022

Language: Английский

Citations

142
Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations DOI

Hanif Afsharara,

Elham Asadian, Bahar Mostafiz

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 160, P. 116949 - 116949

Published: Jan. 21, 2023

Language: Английский

Citations

79
A Look at the Importance of Chirality in Drug Activity: Some Significative Examples DOI Creative Commons
Jessica Ceramella, Domenico Iacopetta,

Angelica Franchini

et al.

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(21), P. 10909 - 10909

Published: Oct. 27, 2022

Chirality plays an important role in the development of many pharmaceuticals, being a general property ‘handedness’; nevertheless, large number pharmaceuticals are still marketed and administered as racemates. is all around even within us; indeed, receptors enzymes chiral entities interact specific manner with drugs. Consequently, controlling enantiomeric purity isolating enantiomers from drugs remains crucial subject for analytical, clinical, regulatory purposes, thus, improving drug safety profile. The classical examples spontaneous enantiomerization severe toxicity related to chirality represented by ibuprofen thalidomide, respectively, but numerous other cases have been reported literature. This review intends offer brief overview on most common used therapy treatment various diseases.

Language: Английский

Citations

74
Recent updates on 1,2,3-triazole-containing hybrids with in vivo therapeutic potential against cancers: A mini-review DOI

Shijia Zhao,

Jie Liu,

Zaosheng Lv

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 251, P. 115254 - 115254

Published: March 6, 2023

Language: Английский

Citations

50
Targeting Breast Cancer: An Overlook on Current Strategies DOI Open Access
Domenico Iacopetta, Jessica Ceramella, Noemi Baldino

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3643 - 3643

Published: Feb. 11, 2023

Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause death among women worldwide. Globally, BC second frequent first gynecological one, affecting with relatively low case-mortality rate. Surgery, radiotherapy, chemotherapy are main treatments for BC, even though latter often not aways successful because common side effects damage caused to healthy tissues organs. Aggressive metastatic BCs difficult treat, thus new studies needed in order find therapies strategies managing these diseases. In this review, we intend give an overview field, presenting data from literature concerning classification drugs used therapy treatment BCs, along clinical studies.

Language: Английский

Citations

47
Unveiling biological activities of biosynthesized starch/silver-selenium nanocomposite using Cladosporium cladosporioides CBS 174.62 DOI Creative Commons
Fathy M. Elkady, Amr H. Hashem, Salem S. Salem

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 8, 2024

Abstract Background and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. Methodology St/Ag-Se NC was using Cladosporium cladosporioides CBS 174.62 ( C. ) strain. shape average particle size investigated scanning electron microscope (SEM) high-resolution transmission (HR-TEM), respectively. On other hand, on two cancer cell lines red blood (RBCs) evaluated its hydrogen peroxide (H 2 O scavenging Moreover, effects microbial species in both planktonic biofilm growth forms examined. Results successfully oval spherical mean diameter 67.87 nm as confirmed by HR-TEM analysis. showed promising anticancer activity toward human colorectal carcinoma (HCT-116) breast (MCF-7) where IC 50 21.37 19.98 µg/ml, Similarly, little RBCs observed low concentration. As well, highest H (42.84%) recorded at concentration mg/ml. Additionally, Staphylococcus epidermidis S. ATCC 12,228 Candida albicans 10,231 highly affected bacterial fungal strains minimum inhibitory concentrations (MICs) 18.75 noticeable dependent. A high suppression percentage, 87.5% 68.05%, aureus when exposed 1 mg/ml 0.5 mg/ml, Conclusion excellent antioxidant activity, haemocompatibility, anti-proliferative concentrations. Also, it exhibited antibiofilm activities.

Language: Английский

Citations

17
Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like Cells DOI Open Access

Youssef Al Hmada,

Robert T. Brodell,

Naji Kharouf

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 470 - 470

Published: Jan. 22, 2024

Melanoma is the third most common type of skin cancer, characterized by its heterogeneity and propensity to metastasize distant organs. a heterogeneous tumor, composed genetically divergent subpopulations, including small fraction melanoma-initiating cancer stem-like cells (CSCs) many non-cancer stem (non-CSCs). CSCs are their unique surface proteins associated with aberrant signaling pathways causal or consequential relationship tumor progression, drug resistance, recurrence. Melanomas also harbor significant alterations in functional genes (BRAF, CDKN2A, NRAS, TP53, NF1). Of these, BRAF NRAS oncogenes, 50% melanomas demonstrating mutation (BRAF

Language: Английский

Citations

16
Advantages and Challenges of Using Antimicrobial Peptides in Synergism with Antibiotics for Treating Multidrug-Resistant Bacteria DOI Creative Commons
Regina Meneses Gonçalves,

Bruna Estéfani Dutra Monges,

Karen G. N. Oshiro

et al.

ACS Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Multidrug-resistant bacteria (MDR) have become a global threat, impairing positive outcomes in many cases of infectious diseases. Treating bacterial infections with antibiotic monotherapy has huge challenge modern medicine. Although conventional antibiotics can be efficient against bacteria, there is still need to develop antimicrobial agents that act MDR bacteria. Bioactive peptides, particularly effective specific types are recognized for their selective and action microorganisms and, at the same time, relatively safe well tolerated. Therefore, growing number works proposed use peptides (AMPs) synergism commercial as an alternative therapeutic strategy. This review provides overview critical parameters using AMPs addressing strengths weaknesses this combination therapy vitro vivo models infection. We also cover challenges perspectives approach clinical practice advantages applying artificial intelligence strategies predict most promising therapies between antibiotics.

Language: Английский

Citations

2
Genetic Heterogeneity, Tumor Microenvironment and Immunotherapy in Triple-Negative Breast Cancer DOI Open Access

Eva Kúdelová,

Marek Smolár, Veronika Holubeková

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 14937 - 14937

Published: Nov. 29, 2022

Heterogeneity of triple-negative breast cancer is well known at clinical, histopathological, and molecular levels. Genomic instability greater mutation rates, which may result in the creation neoantigens enhanced immunogenicity, are additional characteristics this type. Clinical outcome poor due to early age onset, high metastatic potential, increased likelihood distant recurrence. Consequently, efforts elucidate mechanisms development, progression, spread have been initiated improve treatment options outcomes for these patients. The extremely complex heterogeneous tumor immune microenvironment made up several cell types commonly possesses disorganized gene expression. Altered signaling pathways mainly associated with mutated genes including p53, PIK3CA, MAPK, positively correlated regulating response. Of note, particular immunity-associated could be used prognostic indexes assess most effective management. Recent findings highlight fact that long non-coding RNAs also play an important role shaping formation, can mediate evasion. Identification signatures, through use multi-omics approaches, effector drive stages carcinogenic process steps developing new strategies targeted prevention. Advances immunotherapy by remodeling host system eradicate cells great promise lead novel therapeutic strategies. Current research focused on combining checkpoint inhibition chemotherapy, PARP inhibitors, vaccines, or natural killer therapy. Targeted therapies response, eliminate resistance, overall patient survival. In future, evolving advancements should implemented personalized medicine state-of-art management

Language: Английский

Citations

69