A Study of Various Medicinal Plants used in Ulcer Treatment: A Review

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2023, Volume and Issue: 2(1), P. 234 - 246

Published: March 15, 2023

Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in skin or mucus membrane lining Whenever there is change equilibrium, such as increased aggression decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are general term any type stomach duodenal ulcer. To develop, peptic need defences to be compromised addition gastric juice acid activity. Ulcers can treated with variety synthetic medications. However, compared herbal remedies, these drugs more costly likely cause side effects. According research, many different ayurvedic doctors traditional medicine practitioners use medicinal plants polyherbal formulations treat ulcers. ulcer disease treatment should focus on symptom alleviation, healing, preventing recurrence. In article, we'll take look at some that have been studied their potential prevention, both ayurveda Western medicine.

Language: Английский

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Bioactivity of Walnut: Investigating the Triterpenoid Saponin Extracts of Juglans regia Kernels for Antioxidant, Anti-diabetic, and Antimicrobial Properties

Progress In Microbes & Molecular Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 21, 2023

The increasing demand for plant-based medicines makes plant research attractive to find natural alternatives that can replace synthetic products or at least reduce their use. Saponins are a group of phytochemical compounds in most herbs, vegetables, and legumes. There two different types saponin compounds, which be classified based on the nature aglycone bound oligosaccharide fragments, whether it is steroid triterpenoid. This paper devoted saponins with triterpenoid aims study relationship between content several biological activities Juglans regia kernel extracts, including antioxidant, antimicrobial antibacterial activities. Antioxidant activity was assessed against free radicals: DPPH ABTS. Oleanolic acid used as standard quantify saponins, measured by vanillin method, whereas Acarbose Tetracycline were positive controls evaluate α-glucosidase inhibitory activities, respectively, walnut extracts. Findings show hydroalcoholic extract (EtOH 70%) has considerable phenolic 59.51 ± 0.26 mg GAE/g total polyphenol contents, while flavonoids condensed tannins 3.14 0.27 QE/g 85.65 0.37 CE/g crude extract, respectively. In terms antioxidant activity, butanolic proved effective IC50 = 7.74 1.49 µg/mL, precipitated showed highest scavenging ABTS radical 33.14 2.96 µg/mL. addition, extracts kernels an even more efficiently than drugs such Acarbose, values 11.66 µg/mL 16.17 versus 18.01 Acarbose. evaluation Bacillus subtilis, Escherichia coli Klebsiella pneumonia strains revealed some could inhibit these bacteria. successfully bioactivities suggesting medicinal plants demonstrate stronger bioactivity pure compounds.

Language: Английский

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Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 380 - 380

Published: Jan. 30, 2023

Juglans regia Linn. is a valuable medicinal plant that possesses the therapeutic potential to treat wide range of diseases in humans. It has been known have significant nutritional and curative properties since ancient times, almost all parts this utilized cure numerous fungal bacterial disorders. The separation identification active ingredients J. as well testing those compounds for pharmacological are currently great interest. Recently, naphthoquinones extracted from walnut observed inhibit enzymes essential viral protein synthesis SARS-CoV-2. Anticancer characteristics synthetic triazole analogue derivatives juglone, unique modifications parent derivative juglone paved way further research area. Though there some articles available on importance regia, comprehensive review article summarize these findings still required. current review, therefore, abridges most recent scientific about antimicrobial, antioxidant, anti-fungal, anticancer various discovered separated chemical different solvents regia.

Language: Английский

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Chemical Profiling, Bioactive Properties, and Anticancer and Antimicrobial Potential of Juglans regia L. Leaves

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1989 - 1989

Published: Feb. 20, 2023

The aim of this study was to assess the biological potential polyphenolic fraction isolated from J. regia leaves, collected in Subcarpathian region (Poland). phenolic profile determined using UPLC-PDA-MS/MS method. Biological activity by evaluating antioxidant, anticancer, antibacterial, and antifungal effects. Prior study, purified not been tested regard. A total 40 compounds (104.28 mg/g dw) were identified, with quercetin 3-O-glucoside pentosides dominating. preparation characterized a high ability chelate iron ions capture O2•− OH• radicals (reaching IC50 values 388.61, 67.78 193.29 µg/mL, respectively). As for anticancer activity, among six cell lines, reduced viability DLD-1, Caco-2, MCF-7 lines most, while antibacterial seven strains, highest susceptibility has demonstrated against K. pneumoniae, S. pyogenes, aureus. Depending on needs, such can be widely used design functional food and/or cosmetics industry.

Language: Английский

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Effects of walnut seed coat polyphenols on walnut protein hydrolysates: Structural alterations, hydrolysis efficiency, and acetylcholinesterase inhibitory capacity

Food Chemistry, Journal Year: 2023, Volume and Issue: 437, P. 137905 - 137905

Published: Oct. 30, 2023

Language: Английский

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Exploring the phenolic profile, antibacterial, and antioxidant properties of walnut leaves (Juglans regia L.)

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(11), P. 6845 - 6853

Published: July 11, 2023

Abstract The aim of this study was to identify phenolic compounds in walnut leaves from northern Iraq and evaluate their ability act as antibacterial antioxidant agents. Phenolic were determined by reversed‐phase HPLC. Antibacterial activity tested against various bacteria. Antioxidant properties evaluated assays, including reducing power DPPH radical scavenging activity. HPLC profiles leaf fractions revealed quercetin, hydroquinone, 4‐hydroxybenzoic acid, caffeic acid three fractions. inhibitory 47.66, 32.41, 51.90 μg/mL for I, II, III, respectively. For ferric activity, fraction II > III I the FRAP observed 64.43, 73.19, 68.18 All extracted had all bacterial strains tested. Observations showed that able produce similar zones inhibition streptomycin most cases. These results suggest plant extract are plausible natural antioxidants could be used prime candidates synthesis drugs can treatment many oxidative stress‐related diseases.

Language: Английский

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Antioxidant and Antiproliferative Activities of Phenolic Extracts of Eriobotrya japonica (Thunb.) Lindl. Fruits and Leaves

Plants, Journal Year: 2023, Volume and Issue: 12(18), P. 3221 - 3221

Published: Sept. 10, 2023

Increasing interest in new sources of secondary metabolites as biologically active substances has resulted an advanced study many plant species. Loquat (Eriobotrya japonica (Thunb.) Lindl. = Rhaphiolepis bibas (Lour.) Galasso & Banfi, Rosaceae family), evergreen, subtropical fruit tree, native to China and Japan, but cultivated southern countries Europe, is a species commonly used folk medicine may be excellent source bioactive compounds. Therefore, the aim present was evaluate profile phenolic constituents E. fruits leaves originating from Tuscany (Italy), well their vitro antioxidant chemopreventive activities on human cancer cell lines breast adenocarcinoma (MCF-7), colon (Caco-2 HT-29), glioblastoma (U87MG). Results revealed that extract displayed higher anticancer potential than contained 25 individual compounds have been characterized quantified by UPLC-PDA-MS method. The antiproliferative activity correlated with content polyphenolic indicating both are good antioxidants exploited nutraceuticals enriching food or components for cosmetic/pharmaceutical industry.

Language: Английский

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Influence of Cold Stress on Physiological and Phytochemical Characteristics and Secondary Metabolite Accumulation in Microclones of Juglans regia L.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4991 - 4991

Published: May 3, 2024

The current study investigated the impact of cold stress on morphological, physiological, and phytochemical properties Juglans regia L. (J. regia) using in vitro microclone cultures. revealed significant stress-induced changes production secondary antioxidant metabolites. According to gas chromatography–mass spectrometry (GC–MS) analyses, conditions profoundly altered metabolism J. microclones. Although overall spectrum metabolites was reduced, key significantly increased. Notably, there a sevenfold (7×) increase juglone concentration. These findings are crucial for advancing walnut metabolomics enhancing our understanding plant responses abiotic factors. Additionally, results aid identifying role individual these processes, which is essential developing strategies improve resilience tolerance adverse conditions.

Language: Английский

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Phytochemical Screening and Bioactive Properties of Juglans regia L. Pollen

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 2046 - 2046

Published: Oct. 18, 2022

Pollen is one of the major by-products walnut tree, yet it poorly investigated. Thus, aim this study was to investigate total phenolics, flavonoids, antioxidant, anticancer potential, and polyphenol profile pollen obtained from male Juglans regia flowers. A 24 phenolic compounds were identified in all them reported for first time raw material. The content polyphenols 408.03 mg/100 g dry weight (dw) most abundant components quercetin 3-O-sophoroside 4',5,7-trihydroxy-3,6-dimethoxyflavone-7-O-beta-D-glucoside. concentration these compounds, as well strongly determined antioxidant cytotoxic activity pollen. Antioxidant action using ABTS CUPRAC methods had values 3.35 0.32 mmol TE/g dw, respectively. In turn, tests chelating ability ferrous ion, O2•- OH- radical scavenging activity, which results expressed IC50, equal 335.01, 459.31, 92.89 µg/mL, Among six cancer cell lines, strongest effect demonstrated Caco-2 (140.65 µg/mL) MCF-7 (140.98 cells. provide valuable previously unpublished data on composition biological potential

Language: Английский

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Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics against Escherichia coli

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 360 - 360

Published: Feb. 9, 2023

The treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well antibiotic resistance-modifying activity. In this study, perillyl alcohol hydrocinnamic acid were characterized their action against Escherichia coli. Furthermore, dual triple combinations these molecules with antibiotics chloramphenicol amoxicillin investigated first time. Perillyl had a minimum inhibitory concentration (MIC) 256 µg/mL bactericidal (MBC) 512 µg/mL. Hydrocinnamic MIC 2048 an MBC > Checkerboard time-kill assays synergism or additive chloramphenicol/perillyl alcohol, chloramphenicol/hydrocinnamic acid, amoxicillin/hydrocinnamic at low concentrations both molecules. Combenefit analysis showed various each phytochemical. Combinations revealed mainly (up 2 μg/mL alcohol; 0.5 acid). results highlight potential combinatorial therapies microbial growth control, where phytochemicals can play important role potentiators agents.

Language: Английский

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