Experimental and Clinical Gastroenterology,
Journal Year:
2023,
Volume and Issue:
12, P. 4 - 68
Published: May 20, 2023
Summary
Post-
COVID
syndrome
refers
to
the
long-term
consequences
of
a
new
coronavirus
infection
COVID-19,
which
includes
set
symptoms
that
develop
or
persist
after
COVID-19.
Symptoms
gastrointestinal
disorders
in
post-
syndrome,
due
chronic
infl
ammation,
organ
damage,
prolonged
hospitalization,
social
isolation,
and
other
causes,
can
be
persistent
require
multidisciplinary
approach.
The
presented
clinical
practice
guidelines
consider
main
preventive
therapeutic
diagnostic
approaches
management
patients
with
gastroenterological
manifestations
postCOVID
syndrome.
Guidelines
were
approved
by
17th
National
Congress
Internal
Medicine
25th
Gastroenterological
Scientifi
c
Society
Russia.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1429 - 1429
Published: Oct. 6, 2022
Brain
neurodegenerative
diseases
(BND)
are
debilitating
conditions
that
especially
characteristic
of
a
certain
period
life
and
considered
major
threats
to
human
health.
Current
treatments
limited,
meaning
there
is
challenge
in
developing
new
options
can
efficiently
tackle
the
different
components
pathophysiological
processes
these
conditions.
The
renin-angiotensin-aldosterone
system
(RAS)
an
endocrine
axis
with
important
peripheral
physiological
functions
such
as
blood
pressure
cardiovascular
homeostasis,
well
water
sodium
balance
systemic
vascular
resistance—functions
which
well-documented.
However,
recent
work
has
highlighted
paracrine
autocrine
RAS
tissues,
including
central
nervous
(CNS).
It
known
hyperactivation
pro-inflammatory
pro-oxidant
effects,
thus
suggesting
its
pharmacological
modulation
could
be
used
management
present
paper
underlines
involvement
pathophysiology
BNDs
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
Huntington’s
(HD),
motor
neuron
(MND),
prion
(PRD),
identification
drugs
pharmacologically
active
substances
act
upon
RAS,
alleviate
their
symptomatology
or
evolution,
thus,
contribute
novel
therapeutic
approaches.
Brain Sciences,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1363 - 1363
Published: Oct. 8, 2022
A
better
understanding
of
biological
and
emotional
variables
associated
with
health-related
quality
life
in
people
long-COVID
is
needed.
Our
aim
was
to
identify
potential
direct
indirect
effects
on
the
relationships
between
sensitization-associated
symptoms,
mood
disorders
such
as
anxiety/depressive
levels,
sleep
suffering
from
post-COVID-19
pain.
One
hundred
forty-six
individuals
who
were
hospitalized
due
COVID-19
during
first
wave
pandemic
long-term
pain
completed
different
patient-reported
outcome
measures
(PROMs),
including
clinical
features,
symptoms
sensitization
central
nervous
system
(Central
Sensitization
Inventory),
(Hospital
Anxiety
Depressive
Scale),
(Pittsburgh
Sleep
Quality
Index),
(paper-based
five-level
version
EuroQol-5D)
a
face-to-face
interview
conducted
at
18.8
(SD
1.8)
months
after
hospitalization.
Different
mediation
models
assess
associations
among
variables.
The
revealed
that
depressive
levels
directly
affected
life;
however,
these
not
statistically
significant
when
included.
In
fact,
effect
symptomatology
(β
=
-0.10,
95%
CI
-0.1736,
-0.0373),
(β=
-0.09,
-0.1789,
-0.0314),
anxiety
-0.1648,
-0.0337)
all
indirectly
mediated
by
quality.
This
study
mediates
relationship
(depressive/anxiety
levels)
reporting
Longitudinal
studies
will
help
determine
implications
findings.
Experimental and Clinical Gastroenterology,
Journal Year:
2023,
Volume and Issue:
12, P. 4 - 68
Published: May 20, 2023
Summary
Post-
COVID
syndrome
refers
to
the
long-term
consequences
of
a
new
coronavirus
infection
COVID-19,
which
includes
set
symptoms
that
develop
or
persist
after
COVID-19.
Symptoms
gastrointestinal
disorders
in
post-
syndrome,
due
chronic
infl
ammation,
organ
damage,
prolonged
hospitalization,
social
isolation,
and
other
causes,
can
be
persistent
require
multidisciplinary
approach.
The
presented
clinical
practice
guidelines
consider
main
preventive
therapeutic
diagnostic
approaches
management
patients
with
gastroenterological
manifestations
postCOVID
syndrome.
Guidelines
were
approved
by
17th
National
Congress
Internal
Medicine
25th
Gastroenterological
Scientifi
c
Society
Russia.