RASAYAN Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(03), P. 1560 - 1574
Published: Jan. 1, 2023
Indazole-based
heterocyclic
compounds
possessing
significant
medicinal
properties
form
the
basis
of
developing
several
pharmaceuticals.Microwave-assisted
organic
synthesis
is
one
most
effective
and
promising
techniques
from
perspective
green
chemistry,
as
it
increases
reaction
rates
yields
while
decreasing
wasteful
byproducts.Functionalization
indazole
derivatives
under
microwave
irradiation
achieving
tremendous
interest
in
recent
times.Various
cross-coupling
reactions
are
generally
utilized
during
microwave-assisted
functionalization
indazoles.This
review
article
chronologically
describes
different
types
indazoles
assisted
by
with
up-to-date
literature
coverage.
Catalysts,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1163 - 1163
Published: Oct. 2, 2022
N-heterocycles
are
ubiquitous
in
natural
products,
pharmaceuticals,
organic
materials,
and
numerous
functional
molecules.
Among
the
current
synthetic
approaches,
transition
metal-catalyzed
C–H
functionalization
has
gained
considerable
attention
recent
years
due
to
its
advantages
of
simplicity,
high
atomic
economy,
ready
availability
starting
materials.
In
field
N-heterocycle
synthesis
via
functionalization,
nickel
been
recognized
as
one
most
important
catalysts.
this
review,
we
will
introduce
nickel-catalyzed
intramolecular
intermolecular
pathways
for
from
2008
2021.
Tetrahedron Chem,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100116 - 100116
Published: Dec. 1, 2024
The
indazole
core
is
prevalently
found
in
the
structures
of
bioactive
molecules,
demonstrating
promising
potential
medicinal
chemistry
and
drug
discovery,
which
therefore
has
attracted
sustained
attention
from
synthetic
community.
Over
recent
decades,
significant
progress
been
achieved
both
organic
photocatalysis
electrosynthesis,
offering
novel
approaches
for
efficient
sustainable
synthesis
various
functionalized
indazoles.
This
mini-review
highlights
emerging
methodological
advancements
photo-/electro-chemical
two
common
forms
indazole,
namely
1H-
2H-indazoles,
are
classified
by
specific
intramolecular
bond
formation
patterns:
(1)
C-C
formation,
(2)
C-N
(3)
N-N
formation.
reaction
conditions,
representative
scopes,
mechanistic
understandings
these
protocols
emphasized,
to
elucidate
advantages
limitations
current
strategies,
with
an
aim
inspire
future
innovations
that
may
address
challenges
modern
synthesis.Graphical
abstractTo
create
your
abstract,
type
over
instructions
template
box
below.
Fonts
or
abstract
dimensions
should
not
be
changed
altered.
Current Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
27(12), P. 997 - 1009
Published: June 1, 2023
Abstract:
Nitrogen
ring
junction
heterocycles
play
a
crucial
role
in
synthetic
organic
chemistry
due
to
their
remarkable
activity.
The
fused
nitrogen
compounds
are
abundant
nature;
they
have
excellent
biological
activity
and
used
against
various
health
issues.
To
make
selective
products
from
the
heterocycles,
expensive
chemicals
catalysts,
like
transition
metal
complexes
composites,
required.
neglect
drawbacks
of
conventional
synthesis
methods
long
reaction
times,
by-product
formation,
lower
selectivity,
low
yields,
an
alternative
nonconventional
light-mediated
techniques
can
be
opted
for.
light
source
uses
radical
mechanism
that
reduces
provides
regio-selective
product,
increases
yield,
decreases
time,
is
cost-effective,
does
not
require
special
catalysts
or
chemicals.
There
variety
sources,
viz.,
UV,
visible,
IR,
laser,
X-ray.
visible
light,
white,
green,
blue
LED
sources
widely
photochemical
method.
This
review
emphasizes
nitrogen-ring
heterocyclic
compounds.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(20), P. 14736 - 14747
Published: Oct. 11, 2023
A
cascade
hexadehydro-Diels–Alder
(HDDA)/[3
+
2]
cycloaddition
reaction
between
tetrayne
and
N,N′-cyclic
acylhydrazone
is
described.
This
strategy
allows
the
efficient
construction
of
fully
substituted
2,3-dihydro-1H-indazole
scaffolds
which
have
insecticidal
activity
against
third
instar
larvae
Mythimna
separata.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(29)
Published: May 11, 2023
Abstract
Herein,
we
report
on
the
discovery
and
development
of
novel
cascade
N−N
bond
forming
reactions
for
synthesis
rare
indazole
acetic
acid
scaffolds.
This
approach
allows
convenient
three
distinct
derivatives
(unsubstituted,
hydroxy,
alkoxy)
by
heating
3‐amino‐3‐(2‐nitroaryl)propanoic
acids
with
an
appropriate
nucleophile/solvent
under
basic
conditions.
The
reaction
tolerates
a
range
functional
groups
electronic
effects
and,
in
total,
23
were
synthesized
characterized.
work
offers
valuable
strategy
useful
scaffolds
drug
programs.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7607 - 7613
Published: Sept. 4, 2024
A
rhodium-catalyzed
one-pot
access
to
valuable
polycyclic
frameworks
of
fluorenone-4-carboxylic
acids
and
diphenic
anhydrides
via
the
oxidative
dimeric
cyclization
aromatic
has
been
developed.
This
transformation
proceeded
carboxyl-assisted
2-fold
C-H
activation
followed
by
intramolecular
Friedel-Crafts
or
dehydration
reactions.
The
silver
salt
additive
plays
a
vital
role
in
chemoselectivity
products.
Diphenic
anhydride
