New recording genes and genetic mutations of H. pylori genome in gastroduodenal disease patients in Basrah province-Iraq DOI Open Access

Ahmed Al-Hilfi,

Ihsan Edan Alsaimary,

Ali Dawood Al-Hilfi

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 30(3)

Published: Jan. 1, 2023

The aim of this study was to investigate the molecular finding most important H. pylori virulence factors cagA, vacA genotypes in gastric biopsies patients with gastroduodenal diseases infected Helicobacter Basrah-Iraq by using conventional PCR and sequencing technologies, give acknowledge about immunopathogenesis studied disorder.A case-control included 112 confirmed healthy individuals as a control group.Data age, gender, smoking, alcohol abuse, family history, occupation, residence, clinical findings for all populations were collected.The show significant effect these an increased risk disorder.

Language: Английский

Updates on global epidemiology, risk and prognostic factors of gastric cancer DOI Creative Commons
Wenjuan Yang, Heping Zhao, Yan Yu

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(16), P. 2452 - 2468

Published: April 24, 2023

Gastric cancer (GC) is defined as the primary epithelial malignancy derived from stomach, and it a complicated heterogeneous disease with multiple risk factors. Despite its overall declining trend of incidence mortality in various countries over past few decades, GC remains fifth most common fourth leading cause cancer-related death globally. Although global burden has shown significant downward trend, severe certain areas, such Asia. ranks third among all types China, accounts for nearly 44.0% 48.6% new cases GC-related deaths world, respectively. The regional differences are obvious, annual increasing rapidly some developing regions. Therefore, early preventive screening strategies urgently needed. clinical efficacies conventional treatments limited, understanding pathogenesis increased demand therapeutic regimens, including immune checkpoint inhibitors, cell immunotherapy vaccines. present review describes epidemiology worldwide, especially summarizes prognostic factors, focuses on novel immunotherapies to develop management patients.

Language: Английский

Citations

186
Bioaccessibility of bioactive compounds present in Persea americana Mill. seed ingredient during oral-gastric digestion with antibacterial capacity against Helicobacter pylori DOI
Vanessa Sánchez-Quezada, Norma Velázquez‐Guadarrama, Sandra Mendoza-Elizalde

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118259 - 118259

Published: April 27, 2024

Language: Английский

Citations

3
Roles of the components of the cag -pathogenicity island encoded type IV secretion system in Helicobacter pylori DOI
Lingzhu Gou,

Xiaoping Yang,

Jianwei Yun

et al.

Future Microbiology, Journal Year: 2024, Volume and Issue: 19(14), P. 1253 - 1267

Published: Aug. 22, 2024

The

Language: Английский

Citations

2
Fusobacterium nucleatum: Unraveling its potential role in gastric carcinogenesis DOI
Vytenis Petkevičius, Konrad Lehr, Juozas Kupčinskas

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(35), P. 3972 - 3984

Published: Sept. 12, 2024

(

Citations

2
Mass Spectrometry-Based Proteomics of Minor Species in the Bulk: Questions to Raise with Respect to the Untargeted Analysis of Viral Proteins in Human Tissue DOI Creative Commons
Shahid Aziz, Faisal Rasheed, Rabaab Zahra

et al.

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 544 - 544

Published: Feb. 15, 2023

(1) Background: Untargeted mass spectrometry (MS)-based proteomic analysis is highly amenable to automation. Software algorithms translate raw spectral data into protein information obtained by a comparison sequence databases. However, the technology has limitations, especially for analytes measured at limit of detection. In expression study human gastric biopsies, question arose whether or not it possible, as well sensible, search viral proteins in addition those from host. (2) Methods: Experimental data-independent MS were analyzed using sequences oncoviruses, and BLAST analyses performed elucidate level homology host proteins. (3) Results: About one hundred assigned, but there was also up 43% (4) Conclusions: There are least two reasons why matches should be used with care. First, plausible that large amounts present so quality peptides derived likely low. As consequence, number false assignments high. Second, homologous found both virus proteomes contribute matching errors. Thus, though shotgun proteomics can technically any database, meaningful results cannot always expected sanity check must performed. Both instrumentation bioinformatic processing MS-based continuously improving lowering detection even further. Nevertheless, output controlled order avoid over-interpretation results.

Language: Английский

Citations

3
Bioaccessibility of Bioactive Compounds Present in Avocado (Persea Americana Mill.) Seed Ingredient During Oral-Gastric Digestion with Antibacterial Capacity Against Helicobacter Pylori DOI
Vanessa Sánchez-Quezada, Norma Velázquez‐Guadarrama, Sandra Mendoza-Elizalde

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Expression of Salivary miRNAs, Clinical, and Demographic Features in the Early Detection of Gastric Cancer: A Statistical and Machine Learning Analysis DOI
Maryam Koopaie,

Sasan Arian-Kia,

Soheila Manifar

et al.

Journal of Gastrointestinal Cancer, Journal Year: 2024, Volume and Issue: 56(1)

Published: Nov. 9, 2024

Language: Английский

Citations

0
New recording genes and genetic mutations of H. pylori genome in gastroduodenal disease patients in Basrah province-Iraq DOI Open Access

Ahmed Al-Hilfi,

Ihsan Edan Alsaimary,

Ali Dawood Al-Hilfi

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 30(3)

Published: Jan. 1, 2023

The aim of this study was to investigate the molecular finding most important H. pylori virulence factors cagA, vacA genotypes in gastric biopsies patients with gastroduodenal diseases infected Helicobacter Basrah-Iraq by using conventional PCR and sequencing technologies, give acknowledge about immunopathogenesis studied disorder.A case-control included 112 confirmed healthy individuals as a control group.Data age, gender, smoking, alcohol abuse, family history, occupation, residence, clinical findings for all populations were collected.The show significant effect these an increased risk disorder.

Language: Английский

Citations

0