A Nanoscale Cobalt Functionalized Strandberg-Type Phosphomolybdate with β-Sheet Conformation Modulation Ability in Anti-Amyloid Protein Misfolding DOI Creative Commons
Man Wang, Jiai Hua,

Pei Zheng

et al.

Inorganics, Journal Year: 2023, Volume and Issue: 11(11), P. 442 - 442

Published: Nov. 18, 2023

For decades, amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures have been linked to the occurrence and advancement of Alzheimer’s disease (AD) development progression. As a result, modulating mode Aβ has regarded as an important anti-amyloid protein strategy. A polyoxometalate based on {Co(H2O)4}2+ complex [P2Mo5O23]6− fragments, K8{[Co(H2O)4][HP2Mo5O23]2}·8H2O (abbreviated CoPM), synthesized structurally characterized using elemental analysis, single-crystal X-ray diffraction (SXRD), IR, UV spectra, bond valence sums (Σs) calculation, powder XRD (PXRD). CoPM’s primary component, revealed by structural is nanoscale polyoxoanion made [Co(H2O)4]2+ sandwiched between two pieces. Notably, it demonstrated that CoPM efficiently modulates aggregates’ β-sheet-rich conformation.

Language: Английский

Recent advances in the development of polyoxometalates and their composites for the degradation of toxic chemical dyes DOI

Gajiram Murmu,

Tamanna Harihar Panigrahi,

Sumit Saha

et al.

Progress in Solid State Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100489 - 100489

Published: Sept. 1, 2024

Language: Английский

Citations

4
Solvent modulated different stacking of cobalt chelates and their molecular magnetic behaviors DOI
Gaoji Wang,

Ziyi Jin,

Yuxin Chen

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142047 - 142047

Published: March 1, 2025

Language: Английский

Citations

0
A Nanoenzyme Constructed from Manganese and Strandberg-Type Phosphomolybdate with Versatility in Antioxidant and Modulating Conformation of Aβ Protein Misfolding Aggregates In Vitro DOI Open Access
Jiai Hua, Feng Wang,

Xueman Wei

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4317 - 4317

Published: Feb. 21, 2023

Amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures and surplus reactive oxygen species (ROS) are both considered to be the culprit of neuronal toxicity in Alzheimer's disease (AD). Therefore, modulating mode Aβ inhibiting ROS simultaneous has become an important method for anti-AD. Herein, a nanoscale manganese-substituted polyphosphomolybdate (H2en)3[Mn(H2O)4][Mn(H2O)3]2[P2Mo5O23]2·14.5H2O (abbreviated as MnPM) (en = ethanediamine) was designed synthesized by single crystal transformation method. MnPM can modulate rich conformation aggregates, thus reduce formation toxic species. Moreover, also possesses ability eliminate free radicals produced Cu2+-Aβ aggregates. It inhibit cytotoxicity β-sheet-rich protect synapses PC12 cells. combines anti-oxidation ability, which makes promising multi-funcational molecular composite mechanism new conceptual designing treatment such protein-misfolding diseases.

Language: Английский

Citations

6
A nanoscale ferromagnetic nickel-supercluster functionalized giant heterometallic arsenototungstate with ability in catalyzing reactive oxygen species generation DOI
Xiang Ma,

Yusheng Sun,

Qinli Lu

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1291, P. 136010 - 136010

Published: June 17, 2023

Language: Английский

Citations

4
Discovery of Dolutegravir Derivative against Liver Cancer via Inducing Autophagy and DNA Damage DOI Creative Commons

Xixi Hou,

Dong Yan,

Ziyuan Wu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1779 - 1779

Published: April 13, 2024

We introduced a terminal alkyne into the core structure of dolutegravir, resulting in synthesis 34 novel dolutegravir-1,2,3-triazole compounds through click chemistry. These exhibited remarkable inhibitory activities against two hepatocellular carcinoma cell lines, Huh7 and HepG2. Notably, 5e 5p demonstrated exceptional efficacy, particularly cells, with IC50 values 2.64 5.42 μM. Additionally, both induced apoptosis suppressed tumor clone formation, elevated reactive oxygen species (ROS) levels, further promoting apoptosis. Furthermore, activated LC3 signaling pathway, inducing autophagy, triggered γ-H2AX DNA damage cells. Compound low toxicity, highlighting its potential as promising anti-tumor drug.

Language: Английский

Citations

1
An 1,4,7,10-tetraazacyclododecane-nickel complex functionalized polymolybdate acting as artificial oxidase in removing methylene blue DOI
Xiang Ma,

Yujin Li,

Longfeng Meng

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138502 - 138502

Published: May 3, 2024

Language: Английский

Citations

1
A Nanoscale Cobalt Functionalized Strandberg-Type Phosphomolybdate with β-Sheet Conformation Modulation Ability in Anti-Amyloid Protein Misfolding DOI Creative Commons
Man Wang, Jiai Hua,

Pei Zheng

et al.

Inorganics, Journal Year: 2023, Volume and Issue: 11(11), P. 442 - 442

Published: Nov. 18, 2023

For decades, amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures have been linked to the occurrence and advancement of Alzheimer’s disease (AD) development progression. As a result, modulating mode Aβ has regarded as an important anti-amyloid protein strategy. A polyoxometalate based on {Co(H2O)4}2+ complex [P2Mo5O23]6− fragments, K8{[Co(H2O)4][HP2Mo5O23]2}·8H2O (abbreviated CoPM), synthesized structurally characterized using elemental analysis, single-crystal X-ray diffraction (SXRD), IR, UV spectra, bond valence sums (Σs) calculation, powder XRD (PXRD). CoPM’s primary component, revealed by structural is nanoscale polyoxoanion made [Co(H2O)4]2+ sandwiched between two pieces. Notably, it demonstrated that CoPM efficiently modulates aggregates’ β-sheet-rich conformation.

Language: Английский

Citations

0