Steroid‐Hymecromone Conjugates with Improved Antiproliferative and Antimicrobial Potential: Synthesis, Biological Evaluation, and in silico ADME Prediction DOI
Sevinç İlkar Erdağı

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(25)

Published: July 3, 2023

Abstract In this study, hymecromone with known therapeutic aspects was conjugated steroids a class of natural products that widely exhibited broad biological functions. Cholic acid, diosgenin, cholesterol, DHEA, and testosterone were selected as steroid moiety, each which has different mechanism action. This study focused on developing novel conjugates can be used multi‐targeted drugs for treating various diseases. All evaluated in vitro their antiproliferative antimicrobial activities discussed the structure‐activity relationship. The 5 6 comparable cytotoxic effects to reference against cancer cell lines (K562, MCF‐7, HeLa) while showing no toxicity healthy cells (L929). Conjugates 7 demonstrated antibacterial activity Gram‐positive Gram‐negative bacteria, lower minimum inhibitory concentration (MIC) values than standard ciprofloxacin drug. Conjugate , On other hand, had lowest MIC value fungus, drug ketoconazole. physicochemical pharmacokinetic properties silico computed evaluated. Overall, outputs suggest these have promising potential agents, offering approach treatment

Language: Английский

Steroid‐Hymecromone Conjugates with Improved Antiproliferative and Antimicrobial Potential: Synthesis, Biological Evaluation, and in silico ADME Prediction DOI
Sevinç İlkar Erdağı

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(25)

Published: July 3, 2023

Abstract In this study, hymecromone with known therapeutic aspects was conjugated steroids a class of natural products that widely exhibited broad biological functions. Cholic acid, diosgenin, cholesterol, DHEA, and testosterone were selected as steroid moiety, each which has different mechanism action. This study focused on developing novel conjugates can be used multi‐targeted drugs for treating various diseases. All evaluated in vitro their antiproliferative antimicrobial activities discussed the structure‐activity relationship. The 5 6 comparable cytotoxic effects to reference against cancer cell lines (K562, MCF‐7, HeLa) while showing no toxicity healthy cells (L929). Conjugates 7 demonstrated antibacterial activity Gram‐positive Gram‐negative bacteria, lower minimum inhibitory concentration (MIC) values than standard ciprofloxacin drug. Conjugate , On other hand, had lowest MIC value fungus, drug ketoconazole. physicochemical pharmacokinetic properties silico computed evaluated. Overall, outputs suggest these have promising potential agents, offering approach treatment

Language: Английский

Citations

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