Sustainability,
Journal Year:
2023,
Volume and Issue:
15(11), P. 9075 - 9075
Published: June 4, 2023
Grapes,
particularly
the
species
Vitis
vinifera
L.,
are
one
of
most
widely
grown
crops
in
world.
Winemaking
processes
generate
a
high
amount
residues,
which
currently
pose
an
environmental
and
economic
sustainability
problem
for
companies
sector.
For
this
reason,
solutions
being
explored
development
new
products
with
high-added
value
derived
from
valorization
these
residues.
One
wastes
produced
by
winemaking
is
grape
pomace,
chemical
composition
promising
because
it
rich
compounds
antioxidant
activity,
such
as
polyphenols
(anthocyanins,
flavonols,
flavan-3-ols,
procyanidins),
phenolic
acids,
resveratrol,
fiber.
Commonly
pomace
used
to
produce
distillates
extract
tartaric
acid
coloring
substances
enocyanin.
Recently,
alternative
uses
have
been
adopted,
production
extracts
properties,
fermentation
substrates,
composting
biomass
energy
production,
fiber
extraction
high-value-added
enriched
bioactive
molecules
pomace.
Here,
we
discuss
how
involved
various
human
biological
functions
their
applications
agri-food
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1131 - 1131
Published: Sept. 19, 2024
Vitis
vinifera
L.,
commonly
known
as
grapes,
is
one
of
the
most
widely
cultivated
crops
worldwide,
with
over
80%
used
for
wine
production.
However,
winemaking
process
generates
substantial
residues,
including
grape
pomace
(GP),
lees,
and
wastewater,
which
can
pose
significant
environmental
economic
challenges.
Among
these,
GP
stands
out
not
only
a
waste
product
but
also
rich
source
polyphenols—bioactive
compounds
recognized
antioxidant
anti-inflammatory
properties.
Recent
advancements
have
expanded
application
GP-derived
extracts,
particularly
in
health
food
industries,
due
to
their
potent
bioactive
This
review
provides
comprehensive
overview
valorization
GP,
focusing
on
its
phenolic
composition
therapeutic
potential.
It
evokes
innovative,
environmentally
friendly
extraction
techniques
integrated
methods
chemical
analysis
these
valuable
compounds.
Additionally,
benefits
polyphenols
are
explored,
recent
experimental
findings
examining
metabolism
highlighting
key
role
gut
microbiota
processes.
These
insights
contribute
deeper
understanding
biological
activity
extracts
underscore
growing
significance
high-added-value
product.
By
illustrating
how
by-products
be
transformed
into
natural
agents,
this
emphasizes
importance
sustainable
development
eco-friendly
management
practices,
significantly
contributing
advancement
circular
economy.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2035 - 2035
Published: Feb. 26, 2025
Grape
pomace
(GP),
the
residue
left
after
grape
pressing
in
winemaking,
is
rich
polyphenols,
including
flavonoids,
tannins,
and
phenolic
acids,
which
have
antioxidant
anti-inflammatory
properties.
The
present
study
aimed
to
evaluate
cardioprotective
effects
of
white
(WGP)
extract
two
concentrations
polyphenols
(795
mg
from
WGP/kg
body
weight
(bw)
397.5
bw)),
on
isoproterenol
(ISO)-induced
myocardial
infarction
(MI),
focusing
its
effects.
White
administration
for
14
days
offered
a
cardio-protective
effect
prevented
prolongation
QT
QTc
intervals
electrocardiogram.
Both
WGP
elevation
nitric
oxide
(NO)
malondialdehyde
(MDA)
serum,
with
best
results
being
observed
highest
concentration
(p
<
0.05).
reduction
pro-inflammatory
cytokines
such
as
tumor
necrosis
factor
alpha
(TNF-α),
interleukin
6
(IL-6),
1β
(IL-1β)
both
serum
tissue
dose-dependent
manner,
having
Moreover,
reduced
histological
changes
associated
MI.
findings
demonstrate
that
exerts
cardio
protective
by
reducing
MI-associated
inflammation
oxidative
stress.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1089 - 1089
Published: Feb. 27, 2025
Prunus
cerasus
var.
Marasca
(Rosaceae)
is
an
important
Croatian
cultivar,
known
wordwide
for
the
production
of
Luxardo
maraschino
liqueur,
which
occurs
in
eastern
Po
Valley
Italy.
Besides
attractive
its
beneficial
effects
on
human
health
and
well-being.
The
undifferentiated
vitro
cell
cultures
were
investigated
as
a
source
healthy
products.
conditions
obtaining
callus
suspension
under
photoperiod
defined.
lines
evaluated
growth
rate,
total
phenol
proanthocyanidin
contents,
antioxidant
activities
via
colorimetric
assays.
best
also
subcultured
darkness,
studying
importance
light
parameter
possible
industrial
scaling-up.
juices
extracted
from
obtained
biomasses
analyzed
by
LC-DAD-MS
six
flavanone
derivatives,
among
naringenin
glucoside
identified.
quantitative
analysis,
pursued
during
cycle,
revealed
that
content
was
higher
at
end
cycle
(28th
day)
identified
compounds
varied
17.22
to
79.22
μg/mL
juice.
results
anti-inflammatory
Caco-2
cells
support
potential
applications
this
material
health.
Hydroalcoholic
extracts
from
Malbec
and
Torrontés
wine
pomace
(Vitis
vinifera
L.)
originating
the
high-altitude
vineyards
of
Argentina's
Calchaquí
Valleys
were
characterized.
Total
phenolics,
hydroxycinnamic
acids,
orthodiphenols,
anthocyanins,
non-flavonoid
total
flavonoids,
flavones/flavonols,
flavanones/dihydroflavonols,
tannins
quanti-fied
through
spectrophotometric
methods,
with
extract
exhibiting
higher
concentra-tions
in
most
phytochemical
groups
when
compared
to
Torrontés.
HPLC-DAD
identified
more
than
30
phenolic
compounds
both
extracts.
displayed
superior
antiradical
ac-tivity
(ABTS
cation,
nitric
oxide,
superoxide
anion
radicals),
reduction
power
(iron,
copper
phosphomolybdenum),
hypochlorite
scavenging,
iron
chelating
ability,
compara-tively
The
cytotoxicity
assessments
revealed
that
affected
viability
HT29-MTX
Caco-2
colon
cancer
cells
by
70%
50%,
respectively,
at
highest
tested
concentration
(1
mg/mL).
At
same
time,
did
not
demonstrate
acute
toxicity
Artemia
salina
or
red
blood
cell
assays
500
µg/mL.
Both
inhibited
lipoxygen-ase
enzyme,
also
reducing
tyrosinase
activity
neither
xan-thine
oxidase.
substantial
content
diverse
biological
activities
Valleys'
pomaces
underline
their
potentialities
be
valorized
for
pharmaceutical,
cosmetic,
food
industries.
Agriculture,
Journal Year:
2024,
Volume and Issue:
14(7), P. 1142 - 1142
Published: July 14, 2024
The
recognition
of
the
necessity
for
employing
natural
additives
in
animal
feed
has
grown
alongside
ban
on
antibiotics
sector.
Grapes,
as
well
by-products
wine-making
industry
(grape
marc
and
seed
extracts),
possess
biologically
active
chemical
constituents
that
can
be
used
to
improve
production
by
incorporating
them
into
feed.
Grapes
are
a
valuable
resource
polyphenols,
especially
flavonoids,
stilbenes
phenolic
acids,
most
showing
therapeutic
or
health-promoting
properties.
purpose
this
review
is
elucidate
impact
polyphenols
gut
health.
first
section
discusses
structure
major
grapes
polyphenols’
bioavailability
metabolism
pigs.
second
part
reviews
results
investigations
antioxidant,
antimicrobial
prebiotic
effects
grape
pig
diets,
their
regulation
intestinal
barrier
functions
through
signalling
pathways
responses.
All
supported
previous
research,
findings
conclusions.
There
fewer
recorded
studies,
but
inclusion
up
9%
resulted
improved
performance
with
an
increased
mean
daily
gain.
Ultimately,
analysis
concluded
supplementation
pigs
compounds
enhanced
antioxidant
capacity,
humoral
cellular
immune
responses,
promoted
ecosystem
biodiversity
overall
Toxins,
Journal Year:
2024,
Volume and Issue:
16(10), P. 434 - 434
Published: Oct. 10, 2024
Mycotoxins
are
a
major
threat
to
animal
and
human
health,
as
well
the
global
feed
supply
chain.
Among
them,
aflatoxins,
fumonisins,
zearalenone,
T-2
toxins,
deoxynivalenol,
Alternaria
toxins
most
common
mycotoxins
found
in
feed,
with
genotoxic,
cytotoxic,
carcinogenic,
mutagenic
effects
that
concern
industry.
The
chronic
negative
of
on
health
production
economic
impact
livestock
industry
make
it
crucial
develop
implement
solutions
mitigate
mycotoxins.
In
this
review,
we
summarize
current
knowledge
mycotoxicosis
effect
animals
result
their
contaminated
diet.
addition,
discuss
potential
five
promising
phytogenics
(curcumin,
silymarin,
grape
pomace,
olive
orange
peel
extracts)
demonstrated
positive
performance
present
them
anti-mycotoxin
solutions.
We
describe
composition
main
characteristics
these
bioactive
compounds
can
exert
beneficial
performance,
how
phytogenic
additives
help
alleviate
mycotoxins’
deleterious
effects.
The
plethora
of
bio-functional
compounds
present
in
fermented
alcoholic
beverages
like
wine,
as
well
the
valorization
bioactives
from
their
wineries/breweries
by-products
grape
pomace
and
seed,
has
gained
significant
interest
functional
foods
sector.
Wine
always
accompanied
humanity,
for
religion
or
health.
For
example,
Christians
are
using
wine
“Holy
Communion”,
following
what
Jesus
Christ
himself
did
said
during
Last
Supper,
while
benefits
consumption
moderation
was
embedded
all
Mediterranean
civilizations,
it
is
mentioned
by
wise
King-Prophet
David
his
psalms,
but
also
Hip-pocrates
other
men,
a
Greek-based
philosophy
“All
things
Moderation”
(Cleobulus
Lindos;
6th
century
BC).
In
modern
times,
after
outbreak
research
on
since
90’s,
when
term
“French
Paradox”
introduced
US
public
CBS
show,
recent
evidence
outlined
that
these
derived
synergisms
its
digestion-derived
metabolites.
Within
this
article,
proposed
health
moderate
consumption,
component
balanced
diet
(i.e.
Mediterra-nean
Diet),
against
inflammation-related
chronic
disorders,
thoroughly
reviewed.
various
both
wineries’
by-products,
such
bioactive
phe-nolics,
unsaturated
fatty
acids,
polar
lipids,
dietary
fibers,
antioxidant,
anti-inflammatory
antithrombotic
promoting
properties
evaluated.
mechanisms
actions
synergism,
which
elicited,
ex-plored.
Functional
non-alcoholic
products
introduced.
Emphasis
given
to
applications
bioactives,
ingredients
foods,
supplements
nutraceuticals.
Limitations
future
perspectives
popular
beverage
(wine)
ant
rich
addressed.
.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(3), P. 1007 - 1007
Published: Jan. 21, 2025
Winemaking
by-products,
such
as
grape
pomace
and
seed
oil,
provide
sustainable
eco-friendly
resources
for
cosmetics
are
rich
in
bioactive
compounds
like
phenolic
bioactives,
proteins,
lipids
(i.e.,
unsaturated
fatty
acids,
polar
lipids,
carotenoids).
These
compounds,
extracted
using
advanced
techniques
ultrasound,
microwave,
enzyme-assisted
methods,
exhibit
antioxidant,
antimicrobial,
anti-aging,
anti-inflammatory
properties.
In
vitro
vivo
studies
on
keratinocytes
fibroblasts
demonstrate
their
efficacy
enhancing
skin
hydration,
elasticity,
UV
protection
while
reducing
oxidative
stress
inflammation
through
pathways
SIRT1
HSP47.
Encapsulation
further
improve
stability
bioavailability.
The
aim
of
this
review
is
to
investigate
detail
the
extraction
from
winemaking
by-products
evaluate
effectiveness
isolation
lipids.
At
same
time,
it
focuses
application
industry,
highlighting
contribution
products
with
Finally,
special
emphasis
given
encapsulation
bioavailability,
developing
innovative
cosmetic
products.
