Bioactivity of the Genus Turnera: A Review of the Last 10 Years DOI Creative Commons

Aída Parra-Naranjo,

Cecilia Delgado-Montemayor, Ricardo Salazar‐Aranda

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1573 - 1573

Published: Nov. 7, 2023

Turnera is a genus of plants whose biological activity has been widely studied. The importance this genus, particularly diffusa, as source treatment for various conditions evidenced by the large number new studies that have evaluated its activity. Accordingly, objective review was to compile information published in last ten years concerning activities reported spp. present work includes 92 publications evaluate 29 bioactivities and toxicological genotoxic on five species genus. Among pharmacological effects reported, antioxidant, hepatoprotective, neuroprotective, hypoglycemic, aphrodisiac seem more promising. Phytochemicals standardized plant extracts could offer alternative therapeutic remedies diseases. Although several flavonoids, cyanogenic glycosides, monoterpenoids, triterpenoids, fatty acids isolated plants, future research should focus identification main active principles responsible these activities, well perform clinical trials support laboratory results.

Language: Английский

In Silico-Based Identification of Natural Inhibitors from Traditionally Used Medicinal Plants that can Inhibit Dengue Infection DOI
Md Tarikul Islam, Md. Aktaruzzaman,

Ahmed Saif

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Language: Английский

Citations

7
The Volatile Organic Compounds of Streptomyces spp.: An In-Depth Analysis of Their Antifungal Properties DOI Creative Commons
Lorena Cuervo, Samuel Álvarez-García, José A. Salas

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1820 - 1820

Published: July 16, 2023

The study of volatile organic compounds (VOCs) has expanded because the growing need to search for new bioactive that could be used as therapeutic alternatives. These small molecules serve signals establish interactions with other nearby organisms in environment. In this work, we evaluated antifungal effect VOCs produced by different Streptomyces spp. This was performed using VOC chamber devices allow free exchange without physical contact between microorganisms or diffusible they produce. Antifungal activity tested against Escovopsis weberi, a fungal pathogen affects ant nest stability, and results showed CS014, CS057, CS131, CS147, CS159, CS207, CS227 inhibit reduce growth their emitted VOCs. A GS-MS analysis volatiles captured activated charcoal suggested these strains synthesize several VOCs, many them presence E. accumulation various determining inhibition effect.

Language: Английский

Citations

10
Lippia alba essential oil: A powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil DOI

Maria Juliana da L Froz,

Luís de Barros,

Ellen Nayara Silva de Jesus

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118459 - 118459

Published: June 18, 2024

Language: Английский

Citations

3
Comparative Virucidal Activities of Essential Oils and Alcohol-Based Solutions against Enveloped Virus Surrogates: In Vitro and In Silico Analyses DOI Creative Commons
Valentina Parra-Acevedo, Raquel E. Ocazionez, Elena E. Stashenko

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4156 - 4156

Published: May 18, 2023

The large-scale use of alcohol (OH)-based disinfectants to control pathogenic viruses is great concern because their side effects on humans and harmful impact the environment. There an urgent need develop safe environmentally friendly disinfectants. Essential oils (EOs) are generally recognized as (GRAS) by FDA, many exhibit strong antiviral efficacy against human enveloped viruses. present study investigated virucidal disinfectant activity solutions containing EO OH DENV-2 CHIKV, which were used surrogate for quantitative suspension test was used. A solution 12% + 10% reduced > 4.0 log10 TCID50 (100% reduction) both within 1 min exposure. In addition, 3% without after 10 30 exposure, respectively. binding affinities 42 compounds viral envelope proteins through docking analyses. Sesquiterpene showed highest (from −6.7 −8.0 kcal/mol) with E CHIKV E1-E2-E3 proteins. data provide a first step toward defining potential EOs

Language: Английский

Citations

4
Lippia graveolens Essential Oil to Enhance the Effect of Imipenem against Axenic and Co-Cultures of Pseudomonas aeruginosa and Acinetobacter baumannii DOI Creative Commons

Jorge O. Fimbres-García,

Marcela Flores-Sauceda,

Elsa Daniela Othón-Díaz

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(5), P. 444 - 444

Published: May 14, 2024

This research focuses on assessing the synergistic effects of Mexican oregano (Lippia graveolens) essential oil or carvacrol when combined with antibiotic imipenem, aiming to reduce pathogenic viability and virulence Acinetobacter baumannii Pseudomonas aeruginosa. The study highlighted effect combining L. graveolens significantly reducing required doses for inhibiting bacterial growth. combination treatments drastically lowered necessary imipenem doses, highlighting a potent enhancement in efficacy against A. P. For example, minimum inhibitory concentrations (MIC) oil/imipenem combinations were notably low, at 0.03/0.000023 mg/mL 0.0073/0.000023 Similarly, inhibited biofilm formation lower than components used individually, demonstrating strategic advantage this approach combating resistance. OXA-51, showed relatively stable interaction during 30 ns dynamic simulation their interaction, indicating changes (<2 nm) ligand positioning period. Carvacrol exhibited similar fluctuations suggesting its potential inhibition efficacy, while thymol significant variability, particularly >10 ns, instability. With IMP-1, also displayed very interactions 38 demonstrated notable movement within active site, more interaction. In contrast, maintained position site only ~20 ~15 respectively. These results highlight effectiveness tackling difficult-to-treat pathogens

Language: Английский

Citations

1
Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties DOI Creative Commons
Patricia Quintero-Rincón,

Nayive Pino-Benítez,

Elkin Galeano

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(23), P. 3953 - 3953

Published: Nov. 24, 2023

The Colombian Chocó is known for its rich biodiversity and to harbor plant species that are under-explored, including the genus Sloanea. This study aimed analyze chemical composition of derivatized ethanolic extracts from S. chocoana pittieriana using BSTFA TMCS through GC-MS, assess cell viability immortalized human non-tumorigenic keratinocytes (HaCaT) periodontal ligament fibroblast cells crude MTS assay. Antioxidant photoprotective properties were determined DPPH assay spectrophotometry. Antifungal activity against Candida was developed following CLSI standard M27, 4th ed. sun protective factor (SPF) UVA/UVB ratio values calculated Mansur equation Boots star rating system. critical wavelength (λc) by calculating integrated optical density curve's area. transmission erythema pigmentation equations use constants calculate flux pigmentation. GC-MS analysis identified 37 compounds 38 pittieriana, alkaloids, triterpenoids, polyphenolics, among others. Both exhibited proliferative effects on fibroblasts, did not affect HaCaT cells, showed excellent antioxidant activities (46.1% 43.7%). Relevant antifungal observed with extract albicans (GM-MIC: 4 µg/mL), followed C. auris glabrata 32 while active 16 µg/mL, respectively). High SPF (31.0 30.0), λc (393.98 337.81 nm), (1.5 1.2), low percentage respectively. Results Sloanea constitute a promising alternative as ingredients developing skincare products, exhaustive studies required their sustainable uses.

Language: Английский

Citations

3
Antiviral potential of essential oils and their plant sources, delivery methods, and drug development strategies with special focus on their mechanisms: a comprehensive review DOI
Anjie Feng, Tiantian Si,

Baoxiang Du

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Language: Английский

Citations

0
In vitro and in silico analyses of Lippia alba (Verbenaceae) essential oil as an inhibitor of dengue virus and platelet activation DOI
Lina Silva-Trujillo, Raquel E. Ocazionez, Elizabeth Quintero-Rueda

et al.

Journal of Essential Oil Research, Journal Year: 2024, Volume and Issue: 36(5), P. 469 - 480

Published: July 18, 2024

Language: Английский

Citations

0
Antiviral history and viral targets for antiviral therapy DOI
Akram Hegazy, Sara H. Mahmoud, Ahmed Magdy Khalil

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 275

Published: Jan. 1, 2024

Language: Английский

Citations

0
Antiviral activity of natural substances against main arboviruses DENV, ZIKV and CHIKV: literature review DOI Creative Commons

José Lucas Carneiro Da Silva,

Léo Santiago,

Jalyson Vieira Lopes

et al.

Cuadernos de Educación y Desarrollo, Journal Year: 2023, Volume and Issue: 15(7), P. 6765 - 6797

Published: Aug. 15, 2023

Arboviruses have caused several epidemics worldwide, resulting in significant global health problems. Dengue virus (DENV), Zika (ZIKV), and Chikungunya (CHIKV) are endemic arboviruses throughout Brazil a impact on public health. Major gaps protection against the most emerging remain, as no antivirals currently available, vaccines only available few countries. A potential source of antiviral compounds can be found natural products, which been documented to activities expected good efficacy low side effects. Polyphenols plant extracts studied for their properties shown promising results. Natural products continue play an essential role drug production development. This study evaluated substances DENV, ZIKV, CHIKV. Original articles published between 2018 2022 Portuguese English activity were reviewed. total 70 CHIKV, these viruses was analyzed. Some promise developing new compounds. With abundant screen compounds, they important drugs reducing arbovirus cases.

Language: Английский

Citations

0