Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(11), P. 1573 - 1573
Published: Nov. 7, 2023
Turnera
is
a
genus
of
plants
whose
biological
activity
has
been
widely
studied.
The
importance
this
genus,
particularly
diffusa,
as
source
treatment
for
various
conditions
evidenced
by
the
large
number
new
studies
that
have
evaluated
its
activity.
Accordingly,
objective
review
was
to
compile
information
published
in
last
ten
years
concerning
activities
reported
spp.
present
work
includes
92
publications
evaluate
29
bioactivities
and
toxicological
genotoxic
on
five
species
genus.
Among
pharmacological
effects
reported,
antioxidant,
hepatoprotective,
neuroprotective,
hypoglycemic,
aphrodisiac
seem
more
promising.
Phytochemicals
standardized
plant
extracts
could
offer
alternative
therapeutic
remedies
diseases.
Although
several
flavonoids,
cyanogenic
glycosides,
monoterpenoids,
triterpenoids,
fatty
acids
isolated
plants,
future
research
should
focus
identification
main
active
principles
responsible
these
activities,
well
perform
clinical
trials
support
laboratory
results.
Records of Natural Products,
Journal Year:
2023,
Volume and Issue:
4, P. 1 - 18
Published: Aug. 22, 2023
Despite
intense
research
efforts,
no
approved
effective
therapies
are
available
for
dengue
treatment.Standardized
plant
extracts
could
serve
as
potential
candidates
developing
plant-based
treatments
dengue.We
have
compared
the
anti-dengue
of
ethanolic
(EtOH)
and
supercritical
(SCO2)
Lippia
origanoides
Kunth
(Verbenacea).The
mode
antiviral
action
effect
on
release
IL-β
from
DENV-1-stimulated
macrophages
(PMA/THP-1)
were
evaluated.In
silico
analyses
performed
to
predict
molecular
interactions
between
flavonoids
identified
in
UHPLC-ESI+-Orbitrap-MS
analysis
target
proteins.The
EtOH
extract
showed
a
strong
(IC50,
22
17
µg/mL;
SI,
20
23)
before
during
DENV-1
adsorption
liver
(HepG-2)
cells.SCO2
weak
effect.EtOH,
but
not
SCO2,
reduced
level
IL-1β
released
PMA/THP-1
cells
by
45-55%.Flavonoid
glycosides
SCO2.Seventeen
predicted
bind
DENV
E,
GRP78,
CLEC5A,
NLRP3
proteins
involved
replication
production.The
data
provide
first
step
towards
defining
L.
candidate
phytotherapeutics
dengue.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(11), P. 1573 - 1573
Published: Nov. 7, 2023
Turnera
is
a
genus
of
plants
whose
biological
activity
has
been
widely
studied.
The
importance
this
genus,
particularly
diffusa,
as
source
treatment
for
various
conditions
evidenced
by
the
large
number
new
studies
that
have
evaluated
its
activity.
Accordingly,
objective
review
was
to
compile
information
published
in
last
ten
years
concerning
activities
reported
spp.
present
work
includes
92
publications
evaluate
29
bioactivities
and
toxicological
genotoxic
on
five
species
genus.
Among
pharmacological
effects
reported,
antioxidant,
hepatoprotective,
neuroprotective,
hypoglycemic,
aphrodisiac
seem
more
promising.
Phytochemicals
standardized
plant
extracts
could
offer
alternative
therapeutic
remedies
diseases.
Although
several
flavonoids,
cyanogenic
glycosides,
monoterpenoids,
triterpenoids,
fatty
acids
isolated
plants,
future
research
should
focus
identification
main
active
principles
responsible
these
activities,
well
perform
clinical
trials
support
laboratory
results.
