Efficient Synthesis of Pyrrole Disulfides Catalyzed by Lipase in Ethanol DOI Open Access

Feiyang Wen,

Yuelin Xu,

Fengxi Li

et al.

Catalysts, Journal Year: 2023, Volume and Issue: 13(12), P. 1493 - 1493

Published: Dec. 6, 2023

Disulfides, as fundamental scaffolds, are widely present in peptides, natural products, and pharmaceutical molecules. However, traditional synthesis of disulfides often involves the utilization toxic reagents or environmentally unfriendly reaction conditions. In this work, a green efficient method was developed for synthesizing pyrrole using β-ketothioamides ethyl cyanoacetate substrates, with lipase serving catalyst. Under optimal conditions (β-Ketothioamides (1 mmol), PPL (200 U), EtOH (5 mL)), leads to formation yields up 88% at 40 °C. The related mechanism is also speculated paper. This approach not only presents new application enzyme catalytic promiscuity, but offers significant advancement synthetic pathway aligns current mainstream research direction chemistry, contributing further development friendly biocatalytic processes.

Language: Английский

Effect of the support alkyl chain nature in the functional properties of the immobilized lipases DOI
Diandra de Andrades, Pedro Abellanas-Pérez, Javier Rocha‐Martín

et al.

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: 184, P. 110583 - 110583

Published: Jan. 11, 2025

Language: Английский

Citations

2
Phospha-Michael addition of biphenylphosphine oxide to chalcones and α,β-unsaturated esters using the organocatalyst 1,1-diaminobenzalazine DOI
Kriti Mehta, Aabid A. Wani, Prasad V. Bharatam

et al.

Tetrahedron Letters, Journal Year: 2023, Volume and Issue: 122, P. 154505 - 154505

Published: April 21, 2023

Language: Английский

Citations

5
Synthesis of functionalized 1,4-dihydropyridines containing benzosultams catalyzed by lipase DOI
Yaning Xu, Fengxi Li, Yong Tang

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(20), P. 9708 - 9713

Published: Jan. 1, 2023

As a base structural unit, 1,4-dihydropyridines (DHPs) containing benzosultams widely exist in bioactive molecules and drugs.

Language: Английский

Citations

4
A Practical Synthesis of 2‐Arylimino‐2H‐Chromenes via Biocatalytic System in Water DOI
Jinglin Ma, Fengxi Li,

Yuelin Xu

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(20)

Published: May 24, 2023

Abstract A metal‐free, straightforward, non‐hazardous reagent‐added, one‐pot approach for the efficient synthesis of 2‐arylimino‐2 H ‐chromenes with high yields was developed first time in this report through coupling salicylaldehydes β‐ketothioamides, which catalyzed by lipase water. This green strategy provides an method to obtain various and enriches practical application biocatalysis.

Language: Английский

Citations

1
Efficient Synthesis of Pyrrole Disulfides Catalyzed by Lipase in Ethanol DOI Open Access

Feiyang Wen,

Yuelin Xu,

Fengxi Li

et al.

Catalysts, Journal Year: 2023, Volume and Issue: 13(12), P. 1493 - 1493

Published: Dec. 6, 2023

Disulfides, as fundamental scaffolds, are widely present in peptides, natural products, and pharmaceutical molecules. However, traditional synthesis of disulfides often involves the utilization toxic reagents or environmentally unfriendly reaction conditions. In this work, a green efficient method was developed for synthesizing pyrrole using β-ketothioamides ethyl cyanoacetate substrates, with lipase serving catalyst. Under optimal conditions (β-Ketothioamides (1 mmol), PPL (200 U), EtOH (5 mL)), leads to formation yields up 88% at 40 °C. The related mechanism is also speculated paper. This approach not only presents new application enzyme catalytic promiscuity, but offers significant advancement synthetic pathway aligns current mainstream research direction chemistry, contributing further development friendly biocatalytic processes.

Language: Английский

Citations

1