Chemistry,
Journal Year:
2024,
Volume and Issue:
6(4), P. 677 - 694
Published: Aug. 3, 2024
Aaptamine
(8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine),
an
alkaloid
obtained
from
marine
sponges
of
the
genus
Aaptos
(Demospongiae,
Suberitida,
Suberitidae),
has
attracted
significant
attention
as
a
promising
scaffold
for
development
antioxidant,
antibacterial,
and
anticancer
agents.
This
review
offers
extensive
overview
updated
research
on
aaptamine,
focusing
its
multifaceted
pharmacological
properties.
The
antioxidant
potential
aaptamine
reflects
ability
use
in
DPPH
free
radical
scavenging
assay,
suppressing
ROS,
subsequently
deactivating
MAPK
AP-1
signaling
pathway.
Moreover,
it
demonstrates
notable
antibacterial
activity
against
pathogenic
bacteria,
including
mycobacterial
active
dormant
states,
making
candidate
combating
bacterial
infections.
Additionally,
shows
by
inhibiting
cancer
cell
proliferation,
apoptosis
induction,
tumor
growth
through
various
pathways,
regulation
PTEN/PI3K/Akt
CDK2/4,
cyclin
D1/E
cycle
arrest.
unique
chemical
structure
opportunities
structural
modifications
aimed
at
enhancing
activities.
exploration
novel
therapeutic
agents
great
promise
addressing
challenges
associated
with
oxidative
stress,
infections,
cancer.
article
underscores
valuable
marine-derived
fields
therapy.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(37)
Published: Sept. 27, 2024
Abstract
Arum
maculatum
,
cuckoo‐pint
in
folk
linguistics,
is
a
poisonous
but
medicinal
plant
with
tremendous
properties
that
need
investigation.
This
study
subjected
cuckoo‐pint's
parts
to
vitro
antioxidant,
enzyme
inhibition,
and
antimicrobial
susceptibility
testing
investigate
its
biological
activity.
Further,
phytochemistry
was
analyzed
by
both
LC–MS/MS
total
phenol,
flavonoid,
saponin,
reducing
sugar
content
determination
assays.
Antioxidant
activities
were
determined
Fe
3+
Cu
2+
‐TPTZ
metal‐reducing
ability,
1,1‐diphenyl‐2‐picrylhydrazyl
(DPPH)
2,2ʹ‐azino‐bis‐3‐ethylbenzothiazoline‐6‐sulfonic
acid
(ABTS)
radical
scavenging
According
the
results,
seeds
berries
have
remarkable
radical‐scavenging
effects
as
natural
synthetic
analogs
such
ascorbic
acid,
butylated
hydroxyanisole,
hydroxytoluene,
trolox,
α‐tocopherol.
Inhibition
studies
over
human
carbonic
anhydrase
II
(hCA
II),
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
α‐amylase
performed,
IC
50
values
for
each
inhibition.
inhibited
AChE,
BChE,
hCA
activity
greater
than
reference
inhibitors.
Antimicrobial
pan‐resistant
strains
achieved
strain
extracts,
at
least
20
mm
zone
diameter
obtained
lowest
concentrations.
results
revealed
24
bioactive
metabolites
associated
extracts’
Notably,
quinic
epicatechin
correlated
cardioprotective,
neuroprotective,
antidiabetic
IntechOpen eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 30, 2023
Natural
products
and
medicinal
plants
have
been
extremely
important
contributors
to
the
field
of
drug
development
due
their
ability
bind
change
cellular
targets
that
linked
cancer.
On
other
hand,
when
it
comes
quest
for
alternative
treatments
cancer,
bioinformatics
databases
are
critical
importance
cancer
research.
The
knowledge
drug-target
interactions,
prediction
therapeutic
efficacy
side
effects,
identification
novel
repurposing
current
medications
all
made
easier
by
computer-aided
design
network
pharmacology.
Through
use
bioinformatics,
researchers
able
get
a
more
in-depth
understanding
biology
behind
speed
up
process
developing
plant-based
therapy
options
effective,
safe,
affordable
available.
In
this
chapter,
we
provide
comprehensive
review
pharmacology
together
with
in
discovery
era
Journal of Chemical Research,
Journal Year:
2023,
Volume and Issue:
47(6)
Published: Nov. 1, 2023
In
a
five-step
procedure,
18
new
esters
(20a–i
and
21a–i)
of
ataluren
its
analogs
with
dihydroartemisinin
zerumbone
were
synthesized
from
methyl
3-cyanobenzoate.
The
screening
for
their
cytotoxic
activity
against
two
cancer
cell
lines,
HepG2
MCF-7,
showed
that
most
exhibit
the
tested
IC
50
values
in
range
1.61–36.52
µM.
Among
compounds,
ester
21f
containing
4-methoxy
structure
R
did
not
show
activity.
interactions
these
derivatives
epidermal
growth
factor
receptor
protein
also
investigated
by
molecular
docking
studies.
obtained
binding
conformation
revealed
several
notable
results,
demonstrating
similarities
between
modeling
theory
experiment.
These
results
contributed
to
interpreting
vitro
cytotoxicity
proposed
basis
predicting
mechanism
action.
Chemistry,
Journal Year:
2024,
Volume and Issue:
6(4), P. 677 - 694
Published: Aug. 3, 2024
Aaptamine
(8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine),
an
alkaloid
obtained
from
marine
sponges
of
the
genus
Aaptos
(Demospongiae,
Suberitida,
Suberitidae),
has
attracted
significant
attention
as
a
promising
scaffold
for
development
antioxidant,
antibacterial,
and
anticancer
agents.
This
review
offers
extensive
overview
updated
research
on
aaptamine,
focusing
its
multifaceted
pharmacological
properties.
The
antioxidant
potential
aaptamine
reflects
ability
use
in
DPPH
free
radical
scavenging
assay,
suppressing
ROS,
subsequently
deactivating
MAPK
AP-1
signaling
pathway.
Moreover,
it
demonstrates
notable
antibacterial
activity
against
pathogenic
bacteria,
including
mycobacterial
active
dormant
states,
making
candidate
combating
bacterial
infections.
Additionally,
shows
by
inhibiting
cancer
cell
proliferation,
apoptosis
induction,
tumor
growth
through
various
pathways,
regulation
PTEN/PI3K/Akt
CDK2/4,
cyclin
D1/E
cycle
arrest.
unique
chemical
structure
opportunities
structural
modifications
aimed
at
enhancing
activities.
exploration
novel
therapeutic
agents
great
promise
addressing
challenges
associated
with
oxidative
stress,
infections,
cancer.
article
underscores
valuable
marine-derived
fields
therapy.
