Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 421 - 484
Published: Jan. 1, 2024
Language: Английский
Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3599 - 3599
Published: April 20, 2023
With the climate constantly changing, plants suffer more frequently from various abiotic and biotic stresses. However, they have evolved biosynthetic machinery to survive in stressful environmental conditions. Flavonoids are involved a variety of biological activities plants, which can protect different (plant-parasitic nematodes, fungi bacteria) stresses (salt stress, drought UV, higher lower temperatures). contain several subgroups, including anthocyanidins, flavonols, flavones, flavanols, flavanones, chalcones, dihydrochalcones dihydroflavonols, widely distributed plants. As pathway flavonoid biosynthesis has been well studied, many researchers applied transgenic technologies order explore molecular mechanism genes associated with biosynthesis; as such, shown stress tolerance through regulation content. In present review, classification, structure flavonoids were summarized, roles under forms also included. addition, effect applying on enhancement plant was discussed.
Language: Английский
Citations
91
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 1258 - 1258
Published: Aug. 29, 2023
Flavonoids are a large subgroup of polyphenols known to be sourced from over 6000 natural products, including fruits, vegetables, bark, and herbs. Due their antioxidant properties, flavonoids have been implicated as therapy source for many diseases conditions, inflammation, vasculitis, venous insufficiency, hemorrhoids. Currently, some being researched ability concerning neuroprotection. These can penetrate the blood–brain barrier and, depending on specific flavonoid, retain adequate bioavailability in certain brain regions. Further data suggest that could strong anti-inflammatory effect brain, which not only robust therapeutic neuroinflammatory such Alzheimer’s Disease or Parkinson’s but also ischemic hemorrhagic conditions stroke. While flavonoid toxicity exists, they relatively safe non-invasive drugs origins. As such, exploring mechanisms therapies may highlight establish viable stroke patients. stated, already isolated, purified, implemented both vitro vivo experiments. these proceed clinical trials, it will important understand how function therapy, primarily antioxidants, by other secondary mechanisms. This review aims elucidate those explore neuroprotective role flavonoids.
Language: Английский
Citations
20
Biotechnology and Bioprocess Engineering, Journal Year: 2024, Volume and Issue: 29(5), P. 792 - 805
Published: June 27, 2024
Language: Английский
Citations
4
Drugs and Drug Candidates, Journal Year: 2025, Volume and Issue: 4(1), P. 2 - 2
Published: Jan. 9, 2025
The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held its 32nd annual conference August 2024 at University Coimbra, Portugal. There were 8 keynote presentations, 12 early career researcher oral and 34 poster presentations. Four awards delivered, two best communications
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(4), P. 2912 - 2929
Published: Jan. 1, 2025
In this study, we investigated the ability of ortho-quinone methide (o-QM), an electron-poor diene, to undergo inverse electron-demand Diels-Alder (iEDDA) reaction with electron-rich dienophiles, resulting in fused-ring flavonoid systems. addition, explored Michael-type addition using o-QM and various nucleophiles, providing access diarylmethane products. The cycloaddition reactions proceeded a highly regioselective way, depending on charge distribution reacting partners. Overall, dienophiles or nucleophiles reacted intermediate afford products reduced moderate yields. Electron-poor other hand, failed react o-QM.
Language: Английский
Citations
0
Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(2)
Published: March 18, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1602 - 1602
Published: April 3, 2025
The metabolic cycle of L-proline plays a crucial role in cancer cell survival, proliferation, and metastasis. A key intermediate the biosynthesis degradation proline is 3,4-dihydro-2H-pyrrole-2-carboxilic acid. direct route for synthesizing substituted derivatives this acid involves cyclization 2-amino-5-oxonitriles. Michael additions [(diphenylmethylene)amino]acetonitrile to enones basic medium—either with aqueous sodium hydroxide or under solid–liquid phase-transfer catalysis conditions using CaO as base—enable synthesis 2-amino-5-oxonitriles single diastereoisomers diastereoisomeric mixtures. Selective removal diphenylmethylene-protecting group, followed by situ acidic conditions, yields trans- cis-3,5-diaryl-3,4-dihydro-2H-pyrrole-2-carbonitriles. reaction nitriles HCl/dioxane/methanol treatment water produces esters amides by-products. In vitro screening synthesized compounds against multiple human lines revealed that some exhibit good high selectivity index. conclusion, synthetic schemes presented offer simple efficient routes preparation acids, exhibiting promising antiproliferative activity.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2252 - 2252
Published: May 10, 2024
Flavonoids and stilbenoids, crucial secondary metabolites abundant in plants fungi, display diverse biological pharmaceutical activities, including potent antioxidant, anti-inflammatory, antimicrobial effects. However, conventional production methods, such as chemical synthesis plant extraction, face challenges sustainability yield. Hence, there is a notable shift towards using microorganisms like Escherichia coli yeast. Yet, the drawbacks of E. yeast hosts for these compounds persist. For instance, yeast’s complex glycosylation profile can lead to intricate protein scenarios, hyperglycosylation issues. Consequently, Corynebacterium glutamicum emerges promising alternative, given its adaptability recent advances metabolic engineering. Although extensively used biotechnological applications, potential flavonoid stilbenoid engineered C. remains largely untapped compared coli. This review explores engineering biosynthesis, highlighting versatility cell factory assessing optimization strategies pathways. Additionally, various genomic editing biosensors, cofactor regeneration are evaluated, with focus on glutamicum. Through comprehensive discussion, offers insights into future perspectives production, aiding researchers industry professionals field.
Language: Английский
Citations
3
Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 513 - 513
Published: Jan. 19, 2024
During the synthetic studies toward 5,6,7,3',4'-monomethoxytetrahydroxyflavones, a concise pedalitin synthesis procedure was achieved. As previously reported, 6-hydroxy-2,3,4-trimethoxyacetophenone prepared by Friedel-Crafts acylation of 1,4-dihydroxy-2,6-dimethoxybenzene with boron trifluoride diethyl etherate in acetic acid. When aldol condensation
Language: Английский
Citations
2
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 25(1), P. 47 - 62
Published: June 19, 2024
Flavonoids belong to the polyphenol group that naturally exists in fruits, vegetables, tea, and grains. Flavonoids, as secondary metabolites, show indispensable contributions biological processes responses of plants numerous environmental factors. The bioactivity flavonoids depends on C6-C3-C6 ring substitution patterns exhibit bioactive antioxidant, antimicrobial, antifungal, antitumor, anti-inflammatory properties. synthesis has been reported by various methodologies. Therefore, present review systematically summarizes recent heterocyclic flavonoid derivatives via facile synthetic approaches since research is useful for therapeutic biotechnology fields.
Language: Английский
Citations
2