International Journal of Pharmaceutical and Phytopharmacological Research,
Journal Year:
2023,
Volume and Issue:
13(5), P. 53 - 61
Published: Jan. 1, 2023
Cocrystallization
of
drugs
with
coformers
is
a
promising
method
for
modifying
drug
substance
solid
state
qualities
such
as
solubility
and
dissolution.The
current
study
aimed
to
create,
synthesize,
analyze
Nebivolol
hydrochloride
cocrystals
by
screening
several
coformers.The
type
II
biopharmaceutical
medication
(NBH),
used
treat
hypertension,
has
great
permeability,
limited
water
solubility,
slow
dissolving
rate.This
remains
barrier
the
creation
innovative
formulations.In
this
paper,
we
focus
on
formation
first
NBH
zwitterionic
while
using
less
hazardous
amino
acids
coformers,
L-proline
P)
L-glutamine
(G).The
were
synthesized
liquid-aided
grinding
solvent
evaporation
procedures
molar
ratio
(1:1)
zwitterion
revealed
distinctive
characteristic
in
X-ray
diffraction
studies,
FT-IR
spectra,
SEM
images,
DSC
thermograms.The
infrared
demonstrated
displacement
bands.The
X-Ray
Powder
Diffraction
pattern
indicated
co-crystallinity
significant
difference
2θ
value
intense
peaks.Differential
scanning
calorimetry
(DSC)
spectra
changed
endotherms
correlating
melting
point.Dissolution
studies
that
disintegrated
faster
vitro
89.3%
84.7%
respectively.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(2), P. 115 - 127
Published: Jan. 2, 2024
Pharmaceutical
cocrystals,
owing
to
their
manifold
applications,
are
acting
as
bridge
between
drug
discovery
and
pharmaceutical
product
development.
The
ability
scale
up
cocrystals
through
continuous
manufacturing
approaches
offers
superior
economic
products.
Moreover,
can
be
an
aid
for
the
nanoparticulate
systems
solve
issues
related
scale-up
cost.
Cocrystals
grabbed
attention
of
academic
researchers
scientist
due
potential
target
various
diseases
like
cancer.
present
review
is
mainly
focussed
on
diverse
comprehensive
applications
in
delivery
including
solubility
dissolution
enhancement,
improvement
bioavailability
drug,
mechanical
flow
properties
active
ingredients,
controlled/sustained
release
colour
tuning
API.
Besides,
phytochemical
based
multi-drug
tumour
therapy
have
been
discussed
this
review.
Additionally,
recent
progress
pertinent
also
included,
which
may
provide
future
directions
cocrystals.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(10), P. 2208 - 2208
Published: May 8, 2024
Ligustrazine
(TMP)
is
the
main
active
ingredient
extracted
from
Rhizoma
Chuanxiong,
which
used
in
treatment
of
cardiovascular
and
cerebrovascular
diseases,
with
drawback
being
unstable
readily
sublimated.
Cocrystal
technology
an
effective
method
to
improve
stability
TMP.
Three
benzoic
acid
compounds
including
P-aminobenzoic
(PABA),
3-Aminobenzoic
(MABA),
3,5-Dinitrobenzoic
(DNBA)
were
chosen
for
co-crystallization
novel
cocrystals
obtained,
TMP-PABA
(1:2),
TMP-MABA
(1.5:1),
TMP-DNBA
(0.5:1).
Hygroscopicity
was
characterized
by
dynamic
vapor
sorption
(DVS)
method.
significantly
improved
hygroscopicity
stability,
mass
change
TMP
decreased
25%
1.64%
(TMP-PABA),
0.12%
(TMP-MABA),
0.03%
(TMP-DNBA)
at
90%
relative
humidity.
The
melting
points
three
all
higher
than
TMP,
among
cocrystal
had
highest
point
showed
best
reducing
hygroscopicity.
Crystal
structure
analysis
shows
that
mesh-like
formed
O-H⋯N
hydrogen
bond
reason
improving
Crystal Growth & Design,
Journal Year:
2024,
Volume and Issue:
24(11), P. 4652 - 4667
Published: May 15, 2024
Understanding
drug
cocrystal
formation
and
its
competitive
mechanism
is
important
for
improving
the
physicochemical
properties
of
drugs.
In
this
article,
polyhydroxy
natural
products
their
mechanisms
are
discussed
through
experimental
screening
theoretical
calculations.
The
conditions
types
cocrystals
were
determined
based
on
efficient
experiments
product
cocrystals.
To
investigate
difficulty
stability
formation,
carried
out
simultaneously.
By
simulation
electrostatic
potential
surface
molecules
Hirshfeld
crystals,
mode
hydrogen
bonding
within
crystals
was
determined.
strength
assessed
intermolecular
interactions
energy
framework
crystal
structure.
A
"substitution
model"
constructed
results
calculations,
which
great
significance
prediction
design
provides
a
feasible
solution
Polyphenols
(PFs)
are
compounds
found
in
fruits
and
vegetables,
known
for
their
health-related
benefits,
mainly
including
antioxidant,
antiinflammatory,
anticancer
properties.
However,
efficacy
is
limited
by
poor
bioavailability
due
to
issues
like
low
solubility,
rapid
metabolism,
extensive
excretion.
Thus,
research
has
focused
on
improving
delivery
systems,
such
as,
example,
nanoparticles,
hydrogels,
cocrystals,
or
conjugation
with
carrier
molecules,
which
may
protect
PFs
from
degradation,
improve
and/or
facilitate
targeted
cancer
cells.
promising
modulating
cancer-related
pathways
cell
proliferation
death,
metastatic
invasion,
though
translation
patients
hindered
complex
mechanisms.
This
review
analyzes
factors
that
affect
PF
bioavailability,
evidences
of
vivo
effects
animal
models
mechanisms,
results
clinical
trials,
strategies
enhance
bioavailability.
The
idea
need
directly
interact
the
challenged.
Future
aims
optimize
combine
standard
treatments,
explore
epigenetic
effects,
modulation
tumor
microenvironment,
interactions
gut
microbiota.
Advances
personalized
medicine
structural
modifications
stability
absorption
could
further
potential.
Despite
challenges,
remain
a
avenue
complementary
oncotherapy
solutions.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(2), P. 513 - 513
Published: Jan. 19, 2024
During
the
synthetic
studies
toward
5,6,7,3',4'-monomethoxytetrahydroxyflavones,
a
concise
pedalitin
synthesis
procedure
was
achieved.
As
previously
reported,
6-hydroxy-2,3,4-trimethoxyacetophenone
prepared
by
Friedel-Crafts
acylation
of
1,4-dihydroxy-2,6-dimethoxybenzene
with
boron
trifluoride
diethyl
etherate
in
acetic
acid.
When
aldol
condensation
Genes,
Journal Year:
2024,
Volume and Issue:
15(7), P. 828 - 828
Published: June 22, 2024
Polygonati
rhizoma,
known
for
its
distinct
yellow
rhizomes,
is
a
common
therapeutic
and
culinary
plant
in
Far
East
Asia.
The
hue
of
medicinal
plants
closely
tied
to
the
flavonoid
biosynthesis
content
levels.
In
this
research,
fibrous
root
taproot
