Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1000 - 1000
Published: Feb. 25, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. has potent antioxidant capacity, being able capture reactive oxygen species (ROS), nitrogen (RNS), chlorine (ROC), which act as reducing agents by chelating transition-metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its different pharmacological properties of quercetin have been described, such carcinostatic properties; antiviral, antihypertensive, anti-inflammatory ability protect low-density lipoprotein (LDL) oxidation, inhibit angiogenesis; these developed in this review.
Language: Английский
Citations
53
Published: Feb. 2, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet's phenolic phytochemicals and non-energy constituents. has potent antioxidant capacity, being able capture Reactive Oxygen Species (ROS), reactive nitro-gen species (RNS), Chlorine (ROC), which act as reducing agents by chelating transition metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its it was described different pharmacological properties of Quercetin, such carcinostatic properties, antiviral, antihypertensive, anti-inflammatory, protection Low-Density Lipoprotein (LDL) oxidation, inhibi-tion angiogenesis developed in this review.
Language: Английский
Citations
20
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 980 - 980
Published: March 18, 2023
Grape pomace is a byproduct of wineries and rich source phenolic compounds that can exert multiple pharmacological effects when consumed enter the intestine where they then be absorbed. Phenolic are susceptible to degradation interaction with other food constituents during digestion, encapsulation may useful technique for protecting bioactivity controlling its release. Therefore, behavior phenolic-rich grape extracts encapsulated by ionic gelation method, using natural coating (sodium alginate, gum arabic, gelatin, chitosan), was observed simulated digestion in vitro. The best efficiency (69.27%) obtained alginate hydrogels. physicochemical properties microbeads were influenced coatings used. Scanning electron microscopy showed drying had least effect on surface area chitosan-coated microbeads. A structural analysis structure extract changed from crystalline amorphous after encapsulation. released Fickian diffusion, which described Korsmeyer-Peppas model among four models tested. results used as predictive tool preparation containing bioactive could development supplements.
Language: Английский
Citations
22
Current Pharmaceutical Biotechnology, Journal Year: 2024, Volume and Issue: 25(13), P. 1664 - 1692
Published: Oct. 1, 2024
Considering the limited number of current effective treatments, Multidrug- Resistant (MDR) illnesses have grown to be a serious concern public health. It has become necessary look for new antimicrobial drugs because emergence resistance numerous kinds antibiotics. The use flavonoids is one phytotherapeutic strategy that been researched as potential remedy this issue. Secondary plant compounds called found an antibacterial effect against resistant microorganisms.
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116849 - 116849
Published: June 1, 2024
Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a single genetic mutation that leads to repeated polymerization and depolymerization of hemoglobin resulting in intravascular hemolysis, adhesion, vascular occlusion, ischemia–reperfusion injury. Hemolysis causes oxidative damage indirectly generating reactive oxygen species through various pathophysiological mechanisms, which include autoxidation, endothelial nitric oxide synthase uncoupling, reduced bioavailability, elevated levels asymmetric dimethylarginine. Red blood cells have built-in anti-oxidant system includes enzymes like sodium dismutase, catalase, glutathione peroxidase, along with free radical scavenging molecules, such as vitamin C, E, glutathione, help them fight damage. However, these anti-oxidants may not be sufficient prevent effects stress SCD patients. Therefore, line recent FDA request focus placed on development innovative therapies for address root cause disease, there need target restore redox balance This review summarizes current state knowledge regarding role potential benefits therapies. It also discusses challenges limitations suggests future directions research development.
Language: Английский
Citations
4
International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2837 - 2850
Published: Oct. 28, 2024
The chronic non-healing diabetic wound (DW) has remained a challenge to both the society and individuals. Previous studies suggested dietary moderate consumption of quercetin (QCT) are beneficial in preventing complications, including DW. However, there were few that have investigated QCT-related underlying molecular mechanisms against In present study, we for first-time combined network pharmacology with docking experimental validation investigate therapeutic targets treating Finally, 191 1750 DW-related pathogenetic obtained from online databases. After removing duplicates, total 90 potential DW ultimately identified. Furthermore, 7 higher degree IL-6, EGFR, SRC, TNF, AKT1, JUN MMP9 predicted as central QCT Functional enrichment analysis demonstrated exerted strong levels multitargeting regulatory activity. addition, KEGG indicated several signaling pathways AGE-RAGE pathway IL-17, PI3k-AKT, HIF-1, VEGF key regulators Molecular results had binding activity targets. verification experiments could significantly attenuated expression inflammatory cytokines regulation PI3K-AKT was probably vital mechanism involved pharmacological Taken together, validation, first time systematically associated-therapeutic treatment. Our study might provide theoretical basis
Language: Английский
Citations
4
Published: Jan. 1, 2025
Ethnopharmacological relevanceHanchuan Zupa Granule(HCZP) is a classic Uygur medicine compound with long history and proven efficacy. They have been included in the National Essential Medicines List of China are commonly used treatment asthma. It significant importance to elucidate its mechanisms through modern pharmacological research.Aim studyThis study proposes comprehensive research approach combining "disease circadian rhythm-drug target prediction-drug efficacy validation" explore optimal timing mechanism asthma by examining relationship between disease, medication, time, supplemented experimental investigations.Materials methods①Network pharmacology predicted targets HCZP's immune modulation ②Preliminary on antiasthmatic medication times from ancient sources identified most frequent which was for grouping this study. An ovalbumin-induced model lung pathology, pulmonary function, bronchial obstruction were detect condition asthmatic mice. Serum tissue analyzed immunoglobulins Th2 cytokines. MUC5AC mRNA protein levels, along mucus staining, measured evaluate airway secretion.Results①Network analyses showed that among response-related pathways, IL-17 signalling pathway had highest aggregation associated cells pathogenesis. ②In biological effect experiments, HCZP all time subgroups could delay progression pathology certain extent, increased FVC, FEV75, PEF, MMEF, IC different degrees, down-regulated IgE characteristic cytokine expression. In terms reducing expression, expression inhibited varying degrees. asthma, reasonable take "evening (before going bed)"ConclusionThis study, grounded disease rhythm, applies an integrated drug prediction validation treatment. This method anticipated introduce novel strategy clinical therapy.
Language: Английский
Citations
0
BioChem, Journal Year: 2025, Volume and Issue: 5(1), P. 3 - 3
Published: Feb. 11, 2025
The Ebola virus (EBOV), a highly lethal pathogen causing hemorrhagic fever, poses persistent public health threat, with devastating multi-organ complications and high transmission potential through bodily fluids. EBOV’s pathogenesis is marked by severe oxidative stress immune dysregulation, where increased reactive oxygen species (ROS) levels foster cellular damage, hinder defenses, facilitate viral replication. Through evasion suppression of responses, EBOV affects both innate adaptive immunity, activating pyroptosis, PANoptosis, necroptosis, lymphocyte apoptosis, thereby amplifying inflammation disease severity. Recent research suggests that bioactive molecules, including quercetin, curcumin, eugenol, p-anisaldehyde, may offer therapeutic due to their antioxidant, anti-inflammatory, immunomodulatory effects. This review also underscores the conventional treatments, amiodarone, favipiravir, remdesivir, azithromycin, chloroquine, nitazoxanide, as agents against EBOV, thanks antiviral anti-inflammatory properties, although efficacy varies across experimental models. These natural compounds could enhance resilience scavenging ROS, modulating inflammation, mitigating presenting promising adjunctive strategies support therapies.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119836 - 119836
Published: April 1, 2025
Language: Английский
Citations
0