Glutamic acid-catalyzed synthesis of dihydroquinazolinone: anticancer activity, electrochemical behavior, molecular docking, dynamics, simulations and drug-likeness studies DOI
Radhika Mane, Deepak A. Yaraguppi, Avinash Karkada Ashok

et al.

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(7), P. 3271 - 3303

Published: May 27, 2024

Language: Английский

Design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3H)-one-2-carbothioamide derivatives DOI Creative Commons

Le Thanh Hang Nguyen,

Vũ Đình Hoàng, Phạm Minh Quân

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(4), P. 2850 - 2861

Published: Jan. 1, 2025

In this study, we reported the design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4( 3H )-one-2-carbothioamide derivatives.

Language: Английский

Citations

0
A novel magnetic heterojunction NiO@Fe3O4 photocatalyst in the synthesis of cardiovascular quinazolin-4(1H)-one drugs DOI
Zhao Li

Chemical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Synthesis and Antitumor Activity of 6-(2-Aminobenzo[d]thiazol-5-yl) quinazolin-4(3H)-one Derivatives DOI Creative Commons

Ailing Linghu,

L F Tang,

Qing Li

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5686 - 5698

Published: Feb. 10, 2025

Quinazolinones are key scaffolds in anticancer drug development. We previously identified the lead compound 16h from a series of 6-(1H-benzo[d]imidazol-6-yl) quinazolin-4(3H)-one derivatives. In this study, we optimized to develop new 6-(2-aminobenzo[d]thiazol-5-yl) derivatives, with 45 showing best antiproliferative activity against A549 lung cancer cells (IC50: 0.44 μM) and good selectivity. Mechanistic studies revealed that induced G1-phase arrest, inhibited ALK/PI3K/AKT signaling, disrupted mitochondrial membrane potential, promoted apoptosis. It also significantly spheroid formation 3D cell culture model. summary, results suggest might have potential for development drugs.

Language: Английский

Citations

0
Synthesis and antimicrobial evaluation of new quinazolinone derivatives containing thiourea and thiazolidine moieties DOI

Farzaneh Yazdan Kushkoo,

Hojatollah Khabazzadeh, Moj Khaleghi

et al.

Phosphorus, sulfur, and silicon and the related elements, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 11, 2025

Language: Английский

Citations

0
Design and Synthesis of New Quinazolinone Derivatives Conjugated with Chalcone or Pyridazine Moieties: Anticancer Activities and Apoptotic Induction DOI

Dina S. M. Elazab,

Dina I. A. Othman,

Khalid B. Selim

et al.

Polycyclic aromatic compounds, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 3, 2025

Language: Английский

Citations

0
Water-mediated dipole transfer and deoxygenation of nitrones: Experimental and computational mechanistic insights DOI

Divya Bharti,

Manpreet Kaur, Kamlesh K. Gurjar

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141947 - 141947

Published: March 1, 2025

Language: Английский

Citations

0
4(3H)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery DOI Open Access
Ke Chen,

Shumin Wang,

Shuyue Fu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2473 - 2473

Published: March 10, 2025

4(3H)-quinazolinone is a functional scaffold that exists widely both in natural products and synthetic organic compounds. Its drug-like derivatives have been extensively synthesized with interesting biological features including anticancer, anti-inflammatory, antiviral, antimalarial, antibacterial, antifungal, herbicidal, etc. In this review, we highlight the medicinal agrochemical versatility of according to studies published past six years (2019–2024), comprehensively give summary target recognition, structure–activity relationship, mechanism its analogs. The present review expected provide valuable guidance for discovering novel lead compounds containing moiety drug research.

Language: Английский

Citations

0
Citric Acid-Catalyzed Three-Component Synthesis of (E)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1H)-ones and Their Mild Oxidation with I2/DMSO System into (E)-3-Aryl-2-styrylquinazolin-4(3H)-ones DOI Creative Commons
Vladímir V. Kouznetsov,

Angélica Peñaranda Gómez,

Carlos E. Puerto Galvis

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(2), P. 42 - 42

Published: March 16, 2025

We hereby report a simple and efficient method for the preparation of (E)-3-aryl-2-styryl-2,3-dihydroquinazolin-4-(1H)-ones, from isatoic anhydride, anilines, cinnamaldehydes in presence 20 mol% citric acid methanol at 60 °C 2 h. The styryl-dihydroquinazolin-4-(1H)-one products were obtained moderate good yields (30–80%) through three-component condensation reaction, under an environment-friendly protocol. latter easily transformed into styrylquinazolin-4-(3H)-one derivatives with 57–91% using mild oxidation I2/DMSO system less than min.

Language: Английский

Citations

0
One Pot Synthesis and Mechanistic Insights of Quinazoline and related molecules DOI
Pragati Kushwaha,

Ayush Bhardwaj,

Rashi

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134635 - 134635

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis, antimicrobial, cytotoxic and in silico studies of pyridine-quinazolin-4(3H)-one hybrids DOI

Ibrahim A. Bala,

Abdelsattar M. Omar, Yosra A. Muhammad

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142275 - 142275

Published: April 1, 2025

Language: Английский

Citations

0