Methods of Prevention and Mitigation of Autoimmune Diseases - A Review of The Literature DOI Creative Commons
Magdalena Celichowska, Zuzanna Bentkowska, Aleksandra Bogoń

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 17, P. 53121 - 53121

Published: July 21, 2024

Introduction and purpose: Autoimmune diseases are conditions where the body’s immune system is unable to distinguish between auto- foreign antigens mistakenly attacks its cells, tissues, organs. In recent years it became major public health concern because of increasing diagnosis rate. Currently, about 5% population in Western countries affected by such diseases, more often women population. The exact cause autoimmune unknown, although most probably results from a combination genetic predisposition, environmental risk factors dysregulation. Development autoantigen-specific lymphocytes autoantibodies might be decisive starting process autoimmunity. Most common medication used treatment nonsteroidal anti-inflammatory drugs (NSADs), glucocorticoids, disease-modifying antirheumatic (DMARDs). Additionally, there biological available for many them. It known that non-pharmacological interventions, as specific diets, supplementation or physical exercise useful mitigate disease even prevent body onset. Materials methods: data article was found using PubMed Google Scholar websites. key words search included: ‘diet autoimmunity’, ‘autoimmunity estrogens’, ‘microbiota autoimmunity’. Articles not written English, conference abstracts only duplicated papers were excluded. Conclusions: There still no cure various prevention mitigation strategies can help manage these improve quality life individuals. However, use some them, evidence-based recommendations available. This review highlights current therapeutic options.

Language: Английский

Metabolomic and lipidomic fingerprints in inflammatory skin diseases – Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis DOI Creative Commons
Samuel Rischke, S.M.G. Schäfer, Anke König

et al.

Clinical Immunology, Journal Year: 2024, Volume and Issue: 265, P. 110305 - 110305

Published: July 5, 2024

Auto-inflammatory skin diseases place considerable symptomatic and emotional burden on the affected put pressure healthcare expenditures. Although most apparent symptoms manifest skin, systemic inflammation merits a deeper analysis beyond surface. We set out to identify commonalities, as well differences in metabolome lipidome when comparing between healthy controls. Lipidomic metabolomic LC-MS profiling was applied, using plasma samples collected from patients suffering atopic dermatitis, plaque-type psoriasis or hidradenitis suppurativa Plasma profiles revealed notable shift non-enzymatic anti-oxidant defense all three inflammatory disorders, placing cysteine metabolism at center of potential dysregulation. Lipid network enrichment additionally indicated disease-specific provision lipid mediators associated with key roles signaling. These findings will help disentangle components autoimmune dermatological diseases, paving way individualized therapy improved prognosis.

Language: Английский

Citations

2
Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA DOI Open Access
Adam Wroński, Izabela Dobrzyńska, Szymon Sękowski

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12424 - 12424

Published: Aug. 4, 2023

The action of UVA radiation (both that derived from solar and used in the treatment skin diseases) modifies function composition keratinocyte membranes. Therefore, this study aimed to assess effects phytocannabinoids (CBD CBG), singly combination, on contents phospholipids, ceramides, lipid rafts sialic acid membranes exposed radiation, together with their structure functionality. phytocannabinoids, especially combination (CBD+CBG), partially prevented increased levels phosphatidylinositols occurring sphingomyelinase activity after exposure keratinocytes. This was accompanied by a reduction formation malondialdehyde, which correlated parameters responsible for integrity functionality membrane (membrane fluidity permeability transmembrane transporters), compared UVA-irradiated cells. suggests simultaneous use two may have protective effect healthy cells, without significantly reducing therapeutic UV treat diseases such as psoriasis.

Language: Английский

Citations

5
FLAVANOIDS: AN ERA OF NUTRACEUTICALS TURNING IN TO MEDICINAL AGENTS DOI Open Access
Narendra Pentu,

SAI BINDU M,

Rama Rao T

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2024, Volume and Issue: unknown, P. 9 - 17

Published: June 7, 2024

Flavonoids, present in plants, constitute a varied group of naturally occurring compounds well-known for their potential positive effects on health. These molecules fruits, vegetables, and beverages such as tea exhibit antioxidant, anti-inflammatory, other bioactive properties that contribute to impact human In addition, flavonoids act antioxidants, helping plants combat oxidative stress. Some also participate ultraviolet protection, defense against pathogens, modulation plant-microbe interactions. Flavonoids have different subclass flavones, flavonols, flavanones, flavan-3-ols, anthocyanins, isoflavones. The term “bioavailability” describes how well the body absorbs uses flavonoids, broad class plant-based chemicals. chemical structure matrix foods they are eaten interactions with dietary components influence bioavailability. This metabolism can lead formation various metabolites, impacting compounds’ bioactivity. Understanding these aspects is crucial unlocking full promoting health preventing diseases. Patents serve legal protections innovations related plant compounds. Companies researchers seek patents safeguard novel methods extraction, synthesis, applications ensuring exclusivity specified period. incentivizes investment research development, exploration pharmaceuticals, food additives, cosmetics. Ultimately, encourage advancements understanding harnessing diverse benefits across industries.

Language: Английский

Citations

1
3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes DOI Creative Commons
Iwona Jarocka-Karpowicz, Izabela Dobrzyńska, Anna Stasiewicz

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1285 - 1285

Published: Oct. 24, 2024

Phospholipids and their metabolites play an important role in maintaining the membrane integrity metabolic functions of keratinocytes under physiological conditions regeneration process after exposure to high-energy UVB radiation. Therefore, search for compounds with a protective regenerative effect on keratinocyte phospholipids, effectiveness two antioxidant has been tested: stable derivative ascorbic acid, 3-O-ethyl acid (EAA) cannabigerol (CBG), both which are primarily located structures keratinocytes. In addition, this study demonstrated that EAA CBG, especially two-component combination, enhance properties reduce lipid peroxidation assessed at level MDA (malondialdehyde)/neuroprostanes. Moreover, by reducing activity enzymes metabolise free PUFAs (polyunsaturated fatty acids) endocannabinoids (PLA2; phospholipase A2, COX1/2; cyclooxygenases 1/2, LOX-5; lipoxygenase 5, FAAH; amide hydrolase, MAGL; monoacylglycerol lipase), antioxidants have found regulate levels (AEA; anandamide, 2-AG; 2-arachidonoylglycerol, PEA; palmitoylethanolamide) eicosanoids (PGD2; prostaglandin D2, PGE2; E2, 15-d-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2, 15-HETE; 15-hydroxyeicosatetraenoic acid), enhanced The groups PUFA is mainly related activation G protein-related receptors (CB1/2; cannabinoid receptor 1 2, PPARγ; peroxisome proliferator-activated gamma, TRPV1; transient potential cation channel subfamily V member 1), expression reduced influence EAA, combination. It promotes metabolism disrupted UVB, particularly relation redox balance inflammation.

Language: Английский

Citations

1
Skin cells protection against UVA radiation – The comparison of various antioxidants and viability tests DOI Open Access
Agnieszka Gęgotek,

Magda Mucha,

Elżbieta Skrzydlewska

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117736 - 117736

Published: Dec. 1, 2024

This study compares the effects of vitamins - including ascorbic acid, its derivative 3-O-ethyl-ascorbic acid (EAA), and tocopherol as well main non-psychoactive phytocannabinoids on viability various skin cells, healthy (keratinocytes/melanocytes/fibroblasts) cancer cells (melanoma/SCC), under standard culture conditions after exposure to UVA radiation. All conducted tests (MTT, SRB, LDH) consistently indicate that regenerative effect EAA is stronger than while acts selectively healthy/cancer inducing or inhibiting their proliferation, respectively. In case phytocannabinoids, only cannabidiol shows protective/regenerative properties for cells. Moreover, response melanocytes cannabigerol divergent; however, LDH test indicates strongly increases membrane permeability those summary it should be emphasized may give partially divergent results due a variety measured parameters. Nevertheless, despite positive potential protective compound, caution taken promote but also protect

Language: Английский

Citations

1
Effects of combined cannabidiol (CBD) and hops (Humulus lupulus) terpene extract treatment on RAW 264.7 macrophage viability and inflammatory markers DOI Creative Commons
Inga Dammann, Claudia Keil,

I. Hardewig

et al.

Natural Products and Bioprospecting, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 7, 2023

This study investigates the potential of cannabidiol (CBD), one major cannabinoid plant Cannabis sativa, alone and in combination with a terpene-enriched extract from Humulus lupulus ("Hops 1"), on LPS-response RAW 264.7 macrophages as an established vitro model inflammation. With present study, we could support earlier findings anti-inflammatory CBD, which showed dose-dependent [0-5 µM] reduction nitric oxide tumor necrosis factor-alpha (TNF-α) released by LPS-stimulated macrophages. Moreover, observed additive effect after combined CBD [5 hops [40 µg/mL] treatment. The Hops 1 effects cells superior to single substance treatments akin control hydrocortisone. Furthermore, cellular uptake increased dose-dependently presence terpenes extract. its positively correlated terpene concentration, indicated comparison hemp containing both terpenes. These may contribute postulations for so-called "entourage effect" between cannabinoids phytomolecules non-cannabinoid source, such hops, treatment inflammatory diseases.

Language: Английский

Citations

3
Patients’ perspectives on marijuana use for inflammatory bowel disease: a multicenter survey DOI Open Access
Mohammed El-Dallal

Annals of Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

As marijuana use is rising among patients with inflammatory bowel disease (IBD), so interest in its potential as a therapeutic agent. We sought to survey IBD regarding use, self-reported impact on symptoms, and perceptions of safety.A multicenter anonymous was administered between October 2020 June 2021. The 70-question collected demographic variables, clinical attitudes about marijuana, safety efficacy IBD. Participants were classified by their use: "rarely/never," "current," "former". Percentage chi-square tests used compare categorical variables the 3 groups, means 2-group ANOVA for continuous variables.Of 181 surveyed, 166 eligible study. Of these, 70 (42.2%) participants rare/never users, 44 (26.5%) current 52 (31.3%) former users. Fifty-three percent thought would help inflammation 80% it pain. Over 70% from all groups had low-to-moderate risk harm, 69.6% who never or rarely addictive, compared 20.5% users 44% users.While many helps IBD-related pain inflammation, expressed concerns addiction possible harm. Further studies are needed examine benefit harm

Language: Английский

Citations

1
EVALUATION OF CHRONIC STRESS AS AN ETIOLOGY FOR DERMATOLOGICAL DISEASES DOI Creative Commons

Fernanda de Castro Araujo Santana,

Sílvio Vieira da Silva,

Giovanna Maria Gomes Bandeira Pereira

et al.

Revista Ibero-Americana de Humanidades, Ciências e Educação, Journal Year: 2024, Volume and Issue: 10(3), P. 1508 - 1518

Published: March 15, 2024

O estresse crônico é um fenômeno amplamente reconhecido por seus efeitos adversos sobre a saúde física e mental. Embora tenham sido predominantemente associados distúrbios psicológicos, evidências crescentes sugerem sua contribuição para o desenvolvimento de doenças dermatológicas. A pele, como maior órgão do corpo humano, altamente sensível mudanças no estado emocional, refletindo impacto em função integridade. Compreender interação entre as dermatológicas crucial uma abordagem holística tratamento prevenção dessas condições. Objetivo: Examinar criticamente literatura disponível relação dermatológicas, avaliando etiologia mecanismos subjacentes. Metodologia: revisão foi conduzida seguindo diretrizes PRISMA. As bases dados PubMed, Scielo Web of Science foram pesquisadas artigos publicados nos últimos 10 anos. Os descritores utilizados "stress", "chronic stress", "dermatological diseases", "skin disorders" "psychodermatology". critérios inclusão estudos que investigaram associação inglês ou português, humanos. exclusão com amostras não representativas, foco exclusivo psicológicos métodos adequados. Resultados: revelou correlação significativa variedade incluindo dermatite atópica, psoríase, acne alopecia. Mecanismos imunológicos, neuroendócrinos comportamentais implicados na patogênese resposta inflamatória exacerbada disfunção da barreira cutânea identificadas mediadores-chave. Conclusão: emerge fator etiológico relevante destacando importância abordagens integrativas Uma compreensão abrangente interações pode orientar intervenções terapêuticas mais eficazes holísticas, visando apenas os sintomas físicos, mas também fatores psicossociais

Citations

0
Methods of Prevention and Mitigation of Autoimmune Diseases - A Review of The Literature DOI Creative Commons
Magdalena Celichowska, Zuzanna Bentkowska, Aleksandra Bogoń

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 17, P. 53121 - 53121

Published: July 21, 2024

Introduction and purpose: Autoimmune diseases are conditions where the body’s immune system is unable to distinguish between auto- foreign antigens mistakenly attacks its cells, tissues, organs. In recent years it became major public health concern because of increasing diagnosis rate. Currently, about 5% population in Western countries affected by such diseases, more often women population. The exact cause autoimmune unknown, although most probably results from a combination genetic predisposition, environmental risk factors dysregulation. Development autoantigen-specific lymphocytes autoantibodies might be decisive starting process autoimmunity. Most common medication used treatment nonsteroidal anti-inflammatory drugs (NSADs), glucocorticoids, disease-modifying antirheumatic (DMARDs). Additionally, there biological available for many them. It known that non-pharmacological interventions, as specific diets, supplementation or physical exercise useful mitigate disease even prevent body onset. Materials methods: data article was found using PubMed Google Scholar websites. key words search included: ‘diet autoimmunity’, ‘autoimmunity estrogens’, ‘microbiota autoimmunity’. Articles not written English, conference abstracts only duplicated papers were excluded. Conclusions: There still no cure various prevention mitigation strategies can help manage these improve quality life individuals. However, use some them, evidence-based recommendations available. This review highlights current therapeutic options.

Language: Английский

Citations

0