Circular RNA in Cardiovascular Diseases: Biogenesis, Function and Application DOI Creative Commons

Shuai Mei,

Xiaozhu Ma,

Zhou Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 952 - 952

Published: Aug. 6, 2024

Cardiovascular diseases pose a significant public health challenge globally, necessitating the development of effective treatments to mitigate risk cardiovascular diseases. Recently, circular RNAs (circRNAs), novel class non-coding RNAs, have been recognized for their role in disease. Aberrant expression circRNAs is closely linked with changes various cellular and pathophysiological processes within system, including metabolism, proliferation, stress response, cell death. Functionally, serve multiple roles, such as acting microRNA sponge, providing scaffolds proteins, participating protein translation. Owing unique properties, may represent promising biomarker predicting disease progression potential target drug development. This review comprehensively examines biogenesis, mechanisms circRNAs, enhancing understanding impacting Furthermore, prospective clinical applications diagnosis, prognosis, treatment are addressed.

Language: Английский

Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: A systematic review DOI

Zhibo Wang,

Sifan Guo,

Ying Cai

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 144, P. 107090 - 107090

Published: Jan. 10, 2024

Language: Английский

Citations

8
CircLZIC regulates ox-LDL-induced HUVEC cell proliferation and apoptosis via Micro-330-5p/NOTCH2 axis in atherosclerosis DOI Creative Commons

Xingping Men,

Aizhen Hu,

Tingting Xu

et al.

Clinical Hemorheology and Microcirculation, Journal Year: 2024, Volume and Issue: 87(1), P. 115 - 127

Published: Jan. 26, 2024

Atherosclerosis (AS) is a major chronic non-communicable disease and primary cause of cardiovascular disease. Recent studies have shown that circRNAs are potential epigenetic factors regulate vascular endothelial inflammatory responses AS progression. Therefore, identification the ox-LDL levels critical step to understanding pathology AS. Our study aim investigate how circLZIC regulates atherosclerosis via Micro-330-5p/NOTCH2 regulatory axis. The results showed CircLZIC NOTCH2 highly expressed in human clinical samples, while Micro-330-5p locally. CCK-8 experiment promotes proliferation HUVECS cells. Flow cytometry analysis act as an inhibitor HUVEC cell apoptosis. expression level can be up-regulated by transfection small interfering RNA against circLZIC. Further, Starbase predicted could target NOTCH2. Next, we confirmed overexpression significantly reduce fluorescein using double Luciferase reporter assay. RIP-qRT-PCR mRNAs effectively enriched ago2 protein. found knocking down increases apoptosis, inhibiting activity. On other hand, co-transfection decreases inhibit increasing In conclusion, activity signaling pathway, suggesting plays key role development.

Language: Английский

Citations

6
Circular RNAs Variously Participate in Coronary Atherogenesis DOI Creative Commons

Liudmila V. Dergunova,

Margarita A. Vinogradina, Ivan B. Filippenkov

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(8), P. 6682 - 6700

Published: Aug. 13, 2023

Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to class of non-coding arise as result non-canonical splicing premature RNA, which results formation closed single-stranded circRNA molecules lack 5′-end caps 3′-end poly(A) tails. circRNAs broad post-transcriptional regulatory activity. Acting sponge for miRNAs, compete with mRNAs binding acting competing endogenous RNAs. Numerous are involved circRNA–miRNA–mRNA axes associated pathogenesis cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, disease. Recent сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, circ_0003423 disease (CAD) an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, circ_0050486 possess proatherogenic effect. With their high resistance endonucleases, promising diagnostic biomarkers therapeutic targets. This review aims provide updated information on involvement atherogenesis-related CAD. We also discuss main modern approaches detecting studying interactions, well prospects using targets treatment

Language: Английский

Citations

10
MiR-6721-5p as a natural regulator of Meta-VCL is upregulated in the serum of patients with coronary artery disease DOI Creative Commons
Akram Gholipour, Ali Zahedmehr,

Maedeh Arabian

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 25 - 34

Published: Aug. 27, 2024

Language: Английский

Citations

3
Tetramethylpyrazine and paeoniflorin combination (TMP-PF) inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway DOI Creative Commons

Yahui Yuan,

Rong Yuan, Qiqi Xin

et al.

Journal of Future Foods, Journal Year: 2023, Volume and Issue: 4(3), P. 280 - 287

Published: Sept. 21, 2023

Angiogenesis in atherosclerosis (AS) promotes plaque destabilization. miR-126 has a significant role angiogenesis. Tetramethylpyrazine (TMP) and paeoniflorin (PF) have anti-atherosclerotic effects. However, the miR-126-related mechanisms of TMP PF combination (TMP-PF) on angiogenesis AS not been understood. To explore mechanism TMP-PF targeting miR-126. Human umbilical vein endothelial cells (HUVECs) were assigned into control, model, TMP-PF, + inhibitor, simvastatin groups. HUVECs transfected with inhibitor or negative incubated oxidized low-density lipoprotein (ox-LDL) to establish then treated simvastatin. Cell proliferation, migration, tube formation assays are conducted, expression angiogenesis-related factors detected by enzyme-linked immunosorbent assay (ELISA) Western blotting. The level was confirmed polymerase chain reaction (PCR). ox-LDL promoted formation, downregulated expression, increased VEGF, VEGFR2, bFGF, FGFR1. inhibited upregulated decreased FGFR1 ox-LDL-induced HUVECs. effects miR-126, abolished inhibitor. suppressed regulating miR-126/VEGF/VEGFR2 pathway, which might elucidate underlying alleviating AS.

Language: Английский

Citations

5
Candidate SNP Markers Significantly Altering the Affinity of TATA-Binding Protein for the Promoters of Human Hub Genes for Atherogenesis, Atherosclerosis and Atheroprotection DOI Open Access
Anton Bogomolov, Sergey Filonov, И. В. Чадаева

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 9010 - 9010

Published: May 19, 2023

Atherosclerosis is a systemic disease in which focal lesions arteries promote the build-up of lipoproteins and cholesterol they are transporting. The development atheroma (atherogenesis) narrows blood vessels, reduces supply leads to cardiovascular diseases. According World Health Organization (WHO), diseases leading cause death, has been especially boosted since COVID-19 pandemic. There variety contributors atherosclerosis, including lifestyle factors genetic predisposition. Antioxidant diets recreational exercises act as atheroprotectors can retard atherogenesis. search for molecular markers atherogenesis atheroprotection predictive, preventive personalized medicine appears be most promising direction study atherosclerosis. In this work, we have analyzed 1068 human genes associated with atherogenesis, atherosclerosis atheroprotection. hub regulating these processes found ancient. silico analysis all 5112 SNPs their promoters revealed 330 candidate SNP markers, statistically significantly change affinity TATA-binding protein (TBP) promoters. These made us confident that natural selection acts against underexpression At same time, upregulation one promotes health.

Language: Английский

Citations

2
Non-coding RNAs are key players and promising therapeutic targets in atherosclerosis DOI Creative Commons
Zhun Yu,

JinZhu Yin,

Zhitong Tang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Sept. 1, 2023

Cardiovascular disease (CVD) is the primary cause of death in humans. Atherosclerosis (AS) most common CVD and a major many CVD-related fatalities. AS has numerous risk factors complex pathogenesis, while it long been research focus, mechanisms underlying its progression remain unknown. Noncoding RNAs (ncRNAs) represent an important focus epigenetics studies are critical biological regulators that form network gene regulation. Abnormal ncRNA expression disrupts normal function tissues or cells, leading to development. A large body evidence suggests ncRNAs involved all stages atherosclerosis, from initiation progression, some significantly differentially expressed during development, suggesting they may be powerful markers for screening potential treatment targets. Here, we review role development recent developments use AS-targeted therapy, providing as diagnostic therapeutic

Language: Английский

Citations

1
Tetramethylpyrazine and paeoniflorin combination (TMP-PF) alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway DOI Creative Commons

Rong Yuan,

Qiqi Xin, Weili Shi

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 13(5), P. 2642 - 2652

Published: Nov. 3, 2023

Atherosclerosis remains a great threat to human health worldwide. Previous studies found that tetramethylpyrazine (TMP) and paeoniflorin (PF) combination (TMP-PF) exerts anti-atherosclerotic effects in vitro. However, whether TMP-PF improves atherosclerosis vivo needs further exploration. The present study aims assess the properties of in ApoE-/- mice explore related molecule mechanisms. Results showed TMP high-dose decreased serum TG LDL-C levels, suppressed VEGFR2 NR4A1 expression aortic tissues, inhibited plaque angiogenesis, reduced areas, alleviated ApoE-/- mice. Also, exhibited better modulation effect than or PF alone. However, agonist abolished TMP-PF. In conclusion, was first alleviate progression by reducing hyperlipemia inhibiting angiogenesis via NR4A1/VEGFR2 pathway, indicating had positive on attenuating development.

Language: Английский

Citations

1
Circular RNA in Cardiovascular Diseases: Biogenesis, Function and Application DOI Creative Commons

Shuai Mei,

Xiaozhu Ma,

Zhou Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 952 - 952

Published: Aug. 6, 2024

Cardiovascular diseases pose a significant public health challenge globally, necessitating the development of effective treatments to mitigate risk cardiovascular diseases. Recently, circular RNAs (circRNAs), novel class non-coding RNAs, have been recognized for their role in disease. Aberrant expression circRNAs is closely linked with changes various cellular and pathophysiological processes within system, including metabolism, proliferation, stress response, cell death. Functionally, serve multiple roles, such as acting microRNA sponge, providing scaffolds proteins, participating protein translation. Owing unique properties, may represent promising biomarker predicting disease progression potential target drug development. This review comprehensively examines biogenesis, mechanisms circRNAs, enhancing understanding impacting Furthermore, prospective clinical applications diagnosis, prognosis, treatment are addressed.

Language: Английский

Citations

0