Platinum group metal (PGM) complexes having acylthiourea ligand system as catalysts or anticancer agents

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215620 - 215620

Published: Jan. 8, 2024

Language: Английский

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Sythesis, characterisation, anticancer and antimicrobial activity of Ag-N-heterocyclic carbene complexes containing benzimidazole derivatives

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 121992 - 121992

Published: Feb. 22, 2024

Language: Английский

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Cytotoxic Organometallic Iridium(III) Complexes

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 801 - 801

Published: Feb. 9, 2025

Iridium complexes attract a lot of attention as highly promising antitumor agents due to their various structures, which offer the modification physicochemical and biological effects. Compared conventional platinum-based drugs, iridium are commonly thought be more active in tumors, resistant platinum stable air moisture conditions. Chloridoiridium range advantages facilitating rational design, reactivity photochemical activity, leading different cytotoxic profiles, diverse mechanisms action specific intracellular organelles targets. They also known good light-mediated chemotherapeutics, serving bioimaging biosensing agents. The potential photophysical properties chloridoiridium(III) can readily controlled by suitable ligand modifications substitution patterns, providing wide versatile structures. Over years, numerous structural types chloridoiridium have been developed studied for antineoplastic activity. In this review, recent advances cytotoxicity studies compounds summarized. categorized review according number coordinated ligands, type donor atoms, nuclearity complexes, etc., allowing thorough discussion structure-activity relationship.

Language: Английский

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Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 2920 - 2920

Published: March 24, 2023

Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by FDA cancer therapy was cisplatin 1978. Even nearly four and a half decades of trials, there has been no significant improvement osteosarcoma (OS) therapy. In fact, many have developed, but problem raised remains unresolved. This motivates us elucidate possibilities copper zinc (CuZn) combination replace MBD. Thus, anti-chemoresistance properties CuZn their physiological functions OS are highlighted. Herein, we summarise chelators, main organic solvents, ligand structures that involved properties. Through this review, it rational discuss ligands' roles as biosensors drug delivery systems. Hereafter, an in-depth understanding redox photoactive function relationships provided. disadvantage other cannot be elaborated on here. As result, review being which expected intensify with higher cure rates. Nonetheless, advancement intends solve major obstacle towards clinical efficacy.

Language: Английский

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1,2,3-Triazoles and their metal chelates with antimicrobial activity

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 10, 2023

The emergence of drug-resistant bacterial and fungal pathogens has highlighted the urgent need innovative antimicrobial therapeutics. Transition metal complexes with biologically active ligands (coumarins, terpyridines, triazoles, uracils, etc.) have long been investigated for activity. 1,2,3-Triazoles their molecular derivatives are well known a plethora physiological activities, including antibacterial antifungal. aim present mini-review is to inform reader about research conducted on potential 1,2,3-triazole transition metals. What authors find surprising how little such experimentation actually performed reported in scientific literature. goal highlight efforts up now impress upon vast perspectives novel, effective medicinal substances hidden this yet unexplored field.

Language: Английский

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Investigation of the Anticancer Effect of Newly Synthesized Palladium Conjugate Schiff Base Metal Complexes on Non-Small Cell Lung Cancer Cell Line and Mouse Embryonic Fibroblast Cell Line

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 735, P. 150658 - 150658

Published: Sept. 4, 2024

Language: Английский

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Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1729 - 1729

Published: Dec. 15, 2023

Poor responses to medical care and the failure of pharmacological treatment for many high-frequency diseases, such as cancer viral infections, have been widely documented. In this context, numerous metal-based substances, including cisplatin, auranofin, various gold metallodrugs, ruthenium complexes, are under study possible anticancer antiviral agents. The two Ru(III) Ru(II) namely, BOLD-100 RAPTA-C, presently being studied in a clinical trial preclinical studies evaluation, respectively, Interestingly, has also recently demonstrated activity against SARS-CoV-2, which is virus responsible COVID-19 pandemic. Over last years, much effort dedicated discovering new dual anticancer-antiviral Ru-based complexes could be very suitable respect. Thus, review focuses on most recent regarding newly synthesized use and/or

Language: Английский

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Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(6)

Published: April 2, 2024

Oxovanadium (IV) and diphenyltin complexes were synthesized on the nanoscale based Schiff base (H 2 L) derived from salicylaldehyde d ‐glucosamine. The formed with a molar ratio of 1:1 1:2 (metal: dligand) relative to oxovanadium (IV), respectively. Fourier‐transform infrared spectroscopy, 1 H 13 C nuclear magnetic resonance, mass fragmentations, electronic transitions, thermogravimetric analysis, density functional theory employed validate structure compounds. results demonstrated that ligand was successfully attached as di‐anionic mono‐anionic ligands, size investigated using transmission scanning microscope. work presents prospective concept for drug design targeted anticancer through glucose moiety. All compounds revealed remarkable activities against colorectal (HCT‐116) cell line, recording IC 50 values 4.94, 21.73, 62.5 μg/ml VO (II)(L), free L, Sn (ph) (HL) , value (II)(L) complex increased after quercetin inhibitor. Therefore, sugar‐conjugated compound can be recognized by recognition binding site GLUT their cell‐killing effect depends highly inhibitor, quercetin. potential transportability molecular docking study. anti‐migration activity complex. observed best antimicrobial results. antibacterial stimulation represented different interaction types selected ribosyl transferase enzyme.

Language: Английский

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(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 420 - 420

Published: March 30, 2024

The (pentamethylcyclopentadienyl)chloridoiridium(III) complex bearing a κP,κS-bonded Ph2PCH2CH2SPh ligand ([Ir(η5-C5Me5)Cl(Ph2P(CH2)2SPh-κP,κS)]PF6, (1)] was synthesized and characterized. Multinuclear (1H, 13C 31P) NMR spectroscopy employed for the determination of structure. Moreover, SC-XRD confirmed proposed structure belongs to “piano stool” type. Hirshfeld surface analysis outlined most important intermolecular interactions in crystallographic optimized at B3LYP-D3BJ/6-311++G(d,p)(H,C,P,S,Cl)/LanL2DZ(Ir) level theory. applicability this verified through comparison experimental theoretical bond lengths angles, 1H chemical shifts. Natural Bond Orbital theory used identify quantify intramolecular stabilization interactions, especially those between donor atoms Ir(III) ions. Complex 1 tested on antitumor activity against five human tumor cell lines: MCF-7 breast adenocarcinoma, SW480 colon 518A2 melanoma, 8505C thyroid carcinoma A253 submandibular carcinoma. showed superior cisplatin-resistant MCF-7, lines. mechanism tumoricidal action cells indicates involvement caspase-induced apoptosis, accompanied by considerable reduction ROS/RNS proliferation potential treated cells.

Language: Английский

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Cytotoxic Cu(II) Complexes with a Novel Quinoline Derivative Ligand: Synthesis, Molecular Docking, and Biological Activity Analysis

ACS Omega, Journal Year: 2024, Volume and Issue: 9(23), P. 25014 - 25026

Published: May 31, 2024

The utilization of metallodrugs as a viable alternative to organic molecules has gained significant attention in modern medicine. We hereby report synthesis new imine quinoline ligand (IQL)-based Cu(II) complexes and evaluation their potential biological applications. Syntheses the were achieved by condensation 7-chloro-2-hydroxyquinoline-3-carbaldehyde 2,2′-thiodianiline, followed complexation with metal ions. synthesized characterized using UV–vis spectroscopy, TGA/DTA, FTIR 1H 13C NMR pXRD. pXRD diffractogram analysis revealed that its polycrystalline systems, nanolevel average crystallite sizes 13.28, 31.47, 11.57 nm for IQL, CuL, CuL2, respectively. molar conductivity confirmed nonelectrolyte nature complexes. activity was evaluated vitro assays, examine anticancer against MCF-7 human breast cancer cell line antibacterial Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli Pseudomonas aeruginosa) bacterial strains. CuL complex had highest cytotoxic potency cells, an IC50 43.82 ± 2.351 μg/mL. At 100 μg/mL, induced largest reduction proliferation 97%, whereas IQL reduced 53% CuL2 28%. minimum inhibitory concentration found be 12.5 μg/mL three tested pathogens. Evaluation antioxidant 2,2-diphenyl-1-picrylhydrazyl exhibited 153.3 1.02 Molecular docking results showed strong binding affinities active sites S. aureus, E. coli, estrogen receptor alpha, indicating high compared CuL2.

Language: Английский

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