ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4795 - 4803
Published: July 3, 2024
Metallic
nanoparticles
are
promising
candidates
for
anticancer
therapies.
Among
the
different
metallic
systems
studied,
copper
is
an
affordable
and
biologically
available
metal
with
a
high
redox
potential.
Copper-based
widely
used
in
studies
owing
to
their
ability
react
intracellular
glutathione
(GSH)
induce
Fenton-like
reaction.
However,
considering
metastatic
potential
versatility
of
tumor
microenvironment,
modalities
single
therapeutic
agent
may
not
be
effective.
Hence,
enhance
efficiency
chemotherapeutic
drugs,
repurposing
them
or
conjugating
other
essential.
Omeprazole
FDA-approved
proton
pump
inhibitor
clinics
treatment
ulcers.
has
also
been
studied
its
sensitize
cancer
cells
chemotherapy
apoptosis.
Herein,
we
report
nanosystem
comprising
encapsulating
omeprazole
(CuOzL)
against
B16
melanoma
cells.
The
developed
nanoformulation
exerted
significant
synergistic
activity
when
compared
either
alone
by
inducing
cell
death
through
excessive
ROS
generation
subsequent
mitochondrial
damage.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(23), P. 25014 - 25026
Published: May 31, 2024
The
utilization
of
metallodrugs
as
a
viable
alternative
to
organic
molecules
has
gained
significant
attention
in
modern
medicine.
We
hereby
report
synthesis
new
imine
quinoline
ligand
(IQL)-based
Cu(II)
complexes
and
evaluation
their
potential
biological
applications.
Syntheses
the
were
achieved
by
condensation
7-chloro-2-hydroxyquinoline-3-carbaldehyde
2,2′-thiodianiline,
followed
complexation
with
metal
ions.
synthesized
characterized
using
UV–vis
spectroscopy,
TGA/DTA,
FTIR
1H
13C
NMR
pXRD.
pXRD
diffractogram
analysis
revealed
that
its
polycrystalline
systems,
nanolevel
average
crystallite
sizes
13.28,
31.47,
11.57
nm
for
IQL,
CuL,
CuL2,
respectively.
molar
conductivity
confirmed
nonelectrolyte
nature
complexes.
activity
was
evaluated
vitro
assays,
examine
anticancer
against
MCF-7
human
breast
cancer
cell
line
antibacterial
Gram-positive
(Staphylococcus
aureus)
Gram-negative
(Escherichia
coli
Pseudomonas
aeruginosa)
bacterial
strains.
CuL
complex
had
highest
cytotoxic
potency
cells,
an
IC50
43.82
±
2.351
μg/mL.
At
100
μg/mL,
induced
largest
reduction
proliferation
97%,
whereas
IQL
reduced
53%
CuL2
28%.
minimum
inhibitory
concentration
found
be
12.5
μg/mL
three
tested
pathogens.
Evaluation
antioxidant
2,2-diphenyl-1-picrylhydrazyl
exhibited
153.3
1.02
Molecular
docking
results
showed
strong
binding
affinities
active
sites
S.
aureus,
E.
coli,
estrogen
receptor
alpha,
indicating
high
compared
CuL2.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2293 - 2293
Published: Sept. 7, 2023
Nanotechnology,
an
emerging
and
promising
therapeutic
tool,
may
improve
the
effectiveness
of
phototherapy
(PT)
in
antitumor
therapy
because
development
nanomaterials
(NMs)
with
light-absorbing
properties.
The
tumor-targeted
PTs,
such
as
photothermal
(PTT)
photodynamic
(PDT),
transform
light
energy
into
heat
produce
reactive
oxygen
species
(ROS)
that
accumulate
at
tumor
site.
increase
ROS
levels
induces
oxidative
stress
(OS)
during
carcinogenesis
disease
development.
Because
localized
surface
plasmon
resonance
(LSPR)
feature
copper
(Cu),
a
vital
trace
element
human
body,
Cu-based
NMs
can
exhibit
good
near-infrared
(NIR)
absorption
excellent
In
microenvironment
(TME),
Cu2+
combines
H2O2
to
O2
is
reduced
Cu1+
by
glutathione
(GSH),
causing
Fenton-like
reaction
reduces
hypoxia
simultaneously
generates
eliminate
cells
conjunction
PTT/PDT.
Compared
other
modalities,
PTT/PDT
precisely
target
location
kill
cells.
Moreover,
multiple
treatment
modalities
be
combined
treat
using
NMs.
Herein,
we
reviewed
briefly
summarized
mechanisms
actions
role
Cu,
generated
from
NMs,
PTs.
Furthermore,
described
used
applications.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 10, 2025
ABSTRACT
Curcumin
is
a
natural
compound
found
in
turmeric.
It
strong
antioxidant
that
helps
combat
oxidative
stress.
also
known
as
an
effective
agent
for
cancer
therapy.
In
this
study,
we
have
reported
green
synthesis
of
zinc
nanoparticles
using
extracted
curcumin
from
turmeric
and
chitosan
to
modify
the
NPs
surface.
The
synthesized
were
characterized
different
techniques.
XRD
results
revealed
crystallinity
structure
with
crystal
size
45.93
nm.
FE‐SEM
imaging
shows
nonspherical
morphology
average
62.41
vibration
bands
Zn‐O
bonds
are
appearance
at
428,
534,
580
cm
−1
FT‐IR
test.
biological
aspects
focus
recent
study.
Over
course
48
h,
MTT
test
was
used
evaluate
cytotoxic
capacities
Zn
on
SW‐626
HUVEC
normal
cells.
Also,
appraisement
IC
50
butylated
hydroxytoluene
(BHT;
positive
control
DPPH
assay)
relation
41
15
μg/mL,
respectively.
When
exposed
NPs,
cell's
viability
decreased,
resulting
170
μg/mL.
report
mTOR
pathway
indicated
influence
apoptosis
cell
proliferation
cells
through
modulation
PI3K‐Akt‐mTOR
pathway.
could
be
involved
activation
cycle
inhibition
brought
by
NPs.
Consequently,
may
useful
anticancer
therapeutic
ovarian
treatments.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 14, 2025
Breast
cancer
is
the
second
most
prevalent
malignant
tumor
worldwide
and
highly
heterogeneous.
Cuproptosis,
a
newly
identified
form
of
cell
death,
intimately
connected
to
lipid
metabolism.
This
study
investigated
breast
heterogeneity
through
lens
cuproptosis-related
metabolism
genes
(CLMGs),
with
goal
predicting
patient
prognosis,
immunotherapy
efficacy,
sensitivity
anticancer
drugs.
By
utilizing
transcriptomic
data
from
The
Cancer
Genome
Atlas
(TCGA)
for
cancer,
we
682
CLMGs
applied
nonnegative
matrix
factorization
(NMF)
method
categorize
patients
into
four
distinct
clusters:
cluster
1,
''immune-cold
stroma-poor'';
2,
''immune-infiltrated'';
3,
''stroma-rich'';
4,
''moderate
infiltration''.
We
subsequently
developed
risk
model
based
on
that
incorporates
ACSL1,
ATP2B4,
ATP7B,
ENPP6,
HSPH1,
PIP4K2C,
SRD5A3,
ULBP1.
demonstrated
excellent
prognostic
predictive
performance
in
both
internal
(testing
entire
sets)
external
(GSE20685
Kaplan–Meier
Plotter
validation
sets.
High-risk
presented
lower
expression
levels
immune
checkpoint-related
immunophenoscores
(IPSs),
whereas
low-risk
higher
CD8+
T-cell
infiltration
IPSs.
Furthermore,
index
was
positively
correlated
stemness
could
predict
also
confirmed
SRD5A3
expressed
participated
promoting
proliferation
migration
cells.
In
conclusion,
results
this
provide
new
insights
strategies
assessing
prognosis
implementing
precision
treatment
CLMGs.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2779 - 2779
Published: March 19, 2025
As
a
common
malignancy,
hepatocellular
carcinoma
(HCC)
proliferation
and
metastasis
could
be
promoted
by
ferroptosis
cuproptosis.
In
this
study,
we
screened
out
the
differentially
expressed
cuproptosis-
ferroptosis-related
genes
(CFRGs)
identified
17
informative
prognosis-associated
genes.
A
CFRG
scoring
model
was
constructed
based
on
subtypes
consensus
clustering
analysis
principal
component
(PCA).
Furthermore,
immune
profile,
expression
of
checkpoint
(ICGs)
drug
susceptibility
were
also
compared
between
two
score
groups.
The
results
showed
that
patients
with
high
had
higher
survival
probabilities.
correlation
suggested
scores
negatively
correlated
activated
CD4.T.cell.
patterns
thirty
ICGs
half-maximal
inhibitory
concentration
(IC50)
values
128
drugs
displayed
significant
differences
statistically
difference
in
efficacy
sorafenib
found
Moreover,
multivariate
COX
regression
weighted
gene
co-expression
network
(WGCNA),
DLAT
SLC2A1
as
signature
Molecular
docking
revealed
strong
binding
affinity
toward
camptothecin,
rapamycin,
dactolisib,
luminespib.
single-cell
characteristics
further
explored.
study
depended
our
understanding
biological
function
CFRGs
HCC
provided
new
insights
for
developing
treatment
strategies.
