Synthesis and characterization of superparamagnetic PEGylated zero valent iron gold (Fe0Au) nanoparticles

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Iron-gold (Fe⁰-Au) nanoparticles are forefront agents in biomedicine because of their magnetic and plasmonic properties prime candidates for advanced biomedical applications such as hyperthermia, targeted drug delivery, bioimaging. Synthesizing biocompatible, stable iron phase, minimal borate-related cytotoxicity, Fe⁰-Au hybrid a great challenge, This study presents an optimized, two-step synthetic approach to produce PEGylated nanoparticles, employing NaBH₄ reducing agent under strictly anaerobic conditions. UV-Vis spectroscopy confirmed nanoparticle formation, with absorbance peaks at 260 nm Fe⁰ 526 Au, accompanied by discernible color shifts the colloidal suspension, indicative successful metal reduction. High Transmission electron microscopy (HRTEM) revealed uniform spherical morphology average diameter 50 nm, while X-ray photoelectron (XPS) demonstrated substantial minimization borate byproducts, these potentially cytotoxic residues 14 atomic percent. Magnetization assessments showed hysteresis-free superparamagnetic behavior saturation magnetization 75 Am²/kg NPs, validating suitability precision hyperthermia resonance imaging. These findings indicate that PEG functionalization enhances stability effectively mitigates toxicity risks, rendering highly viable preclinical translational applications.

Language: Английский

A Comprehensive Exploration of Superparamagnetic Nanoparticles: Applications and Regulatory Aspects in Medicine and Environmental Areas

Published: Jan. 1, 2023

This review paper highlights the current toxicological aspects of magnetic nanomaterials in field medicine and environment, conducted through a comprehensive literature review. The main goal was to investigate analyze key challenges identified that impede effective utilization these systems, particularly focusing on iron oxide (Fe3O4) nanoparticles. We aimed factors influence their intended applications. sought understand how characteristics produced NPs could be enhanced improve biocompatibility compared existing samples literature. Additionally, we examined morphological directly linked physicochemical potential implications for toxicology ecotoxicology. Furthermore, evaluated regulatory impact nanostructured materials. Therefore, initial aspect this delved into historical evolution nanoparticles, investigating significant milestones have influenced exploration technology. discoveries, influencing choice synthesis methods, most prevalent approaches surface functionalization employed by scientists materials possessing superparamagnetic characteristics, such as oxide. second focused survey-based global regulation progress concerning nanoparticles throughout years. encountered establishing safety criteria diverse applications under investigation. encompassed an assessment impacts both human health environment.

Language: Английский