Comparison of the Metabolomics of Different Dendrobium Species by UPLC-QTOF-MS DOI Open Access
Tingting Zhang, Xinxin Yang, Fengzhong Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17148 - 17148

Published: Dec. 5, 2023

Dendrobium Sw. (family Orchidaceae) is a renowned edible and medicinal plant in China. Although widely cultivated used, less research has been conducted on differential species. In this study, stems from seven distinct species were subjected to UPLC-QTOF-MS/MS analysis. A total of 242 metabolites annotated, multivariate statistical analysis was employed explore the variance extracted across various groups. The demonstrated that D. nobile displays conspicuous differences other Dendrobium. Specifically, stands out remaining six taxa based 170 metabolites, mainly terpene flavonoid components, associated with cysteine methionine metabolism, biosynthesis, galactose metabolism. It believed variations between are attributed three metabolite synthesis pathways. By comparing chemical composition Dendrobium, study identified qualitative components each found differ significantly species, higher levels terpenoids, flavonoids, compounds for cardiovascular field. these have relevance establishing quality standards

Language: Английский

Construction of 3,4-Dihydroquinolone Derivatives through Pd-Catalyzed [4+2] Cycloaddition of Vinyl Benzoxazinanones with α-Alkylidene Succinimides DOI

Ting-Ting Yu,

Peng-Ting Huang,

Ben‐Hong Chen

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(5), P. 3279 - 3291

Published: Feb. 20, 2024

The construction of 3,4-dihydroquinolone derivatives has attracted a considerable amount attention due to their extensive applications in medicinal chemistry. In this study, we present the Pd-catalyzed [4+2] cycloaddition vinyl benzoxazinanones with α-alkylidene succinimides for efficient synthesis 3,4-dihydroquinolones. This approach presents numerous advantages, including ready availability starting materials, mild reaction conditions without use additional bases, and wide range substrates. particular, all desired products can be easily afforded high yields (≤99%) excellent diastereoselectivities (>20:1). practicality reliability strategy were demonstrated by successful scale-up subsequent straightforward synthetic transformations.

Language: Английский

Citations

4
Enantioselective Synthesis of 3‐Allylindoles from Indolin‐2‐imines and MBH Carbonates via Nucleophilic Catalysis DOI

Lunfeng Chen,

Pengfei Li

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(6)

Published: Feb. 7, 2024

Abstract With chiral amine (DHQD) 2 PHAL as nucleophilic catalyst, asymmetric synthesis of enantioenriched 3‐allylindoles was achieved from indolone‐2‐imines and MBH carbonates. Compared with our previous phosphine catalysis, the had exactly opposite effect in terms enantioselectivity. Importantly, we could obtain each enantiomer by adjusting catalyst system.

Language: Английский

Citations

1
Phosphine-Catalyzed [4 + 1] Annulation of β’-Acetoxy Allenoate with α-Alkylidene Succinimides: Access to Functionalized Spirosuccinimide Derivatives DOI
Chunjie Ni,

Zhanhang Liang,

Xiaojuan Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16711 - 16720

Published: Oct. 31, 2024

A phosphine-catalyzed [4 + 1] annulation of β'-acetoxy allenoate with α-alkylidene succinimides is described. This method demonstrates the nucleophilic dialkylation and cyclization succinimides, resulting in formation functionalized spirosuccinimide derivatives. The reaction exhibits a wide substrate scope yields ranging from moderate to excellent under optimized conditions. In addition, biological evaluation indicates that cycloadduct 3u presents satisfied inhibitory activities for three human cancer cell lines (HCT116, A549, HepG2).

Language: Английский

Citations

1
Comparison of the Metabolomics of Different Dendrobium Species by UPLC-QTOF-MS DOI Open Access
Tingting Zhang, Xinxin Yang, Fengzhong Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17148 - 17148

Published: Dec. 5, 2023

Dendrobium Sw. (family Orchidaceae) is a renowned edible and medicinal plant in China. Although widely cultivated used, less research has been conducted on differential species. In this study, stems from seven distinct species were subjected to UPLC-QTOF-MS/MS analysis. A total of 242 metabolites annotated, multivariate statistical analysis was employed explore the variance extracted across various groups. The demonstrated that D. nobile displays conspicuous differences other Dendrobium. Specifically, stands out remaining six taxa based 170 metabolites, mainly terpene flavonoid components, associated with cysteine methionine metabolism, biosynthesis, galactose metabolism. It believed variations between are attributed three metabolite synthesis pathways. By comparing chemical composition Dendrobium, study identified qualitative components each found differ significantly species, higher levels terpenoids, flavonoids, compounds for cardiovascular field. these have relevance establishing quality standards

Language: Английский

Citations

0