The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 3, 2024

Abstract As one of the main sources natural antioxidants, flowering plants play a role in prevention and treatment many diseases directly indirectly. Honey is considered as an important nutrient supply amount which dependent on plant origin geographical location bee feeding place. The existence valuable communities native endemic species has turned Alborz, Zagros Azerbaijan into most hubs honey production Iran. In this study, we collected samples from more than 90 regions during years 2020 to 2021. We evaluated using melissopalynology method measuring antioxidant activity. rise activity abundance some families well botanical origins. Rosaceae, Amaranthaceae, Fabaceae Asteraceae showed higher influence antioxidants other families. Also, Rosaceae increased with increasing altitude. general, shows different percentage under ecological changes.

Language: Английский

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Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata

Plants, Journal Year: 2025, Volume and Issue: 14(3), P. 395 - 395

Published: Jan. 28, 2025

Plants have long been used as sources of natural compounds with therapeutic benefits, providing molecules capable inhibiting multiple kinases. Many medicinal plants are recognized for their anticancer properties and may offer ways to mitigate the adverse effects conventional cancer treatments. In this study, potential Ziziphus mucronata methanol extract a kinase inhibitor was assessed using MTT assay, universal human phosphokinase antibody array, along GC-MS analysis volatile compounds. The assay revealed strong cytotoxicity in A549 cells, an IC50 31.25 µg/mL, while HeLa cells showed weaker 125 µg/mL. comparison, paclitaxel exhibited potent inhibitory on (IC50 µg/mL) moderate inhibition 65 µg/mL). Enzyme activity, measured by ADP production ADP-Glo indicated that inhibited protein activity both after 24 h treatment. Additionally, which includes 44 pre-spotted kinases, downregulated phosphorylated kinases cell lines. Some affected such TOR, Fyn, HcK, Fgr, STAT5b, PLC-γ1, p38α, ERK1/2, AMPKA, Akt1/2, GSK-3α/β, MSK1/2, CREB, RSK1/2/3, STAT5a critical regulators various cellular processes, including apoptosis, differentiation, proliferation. findings study suggest from Z. capacity regulate highlighting significant growth inhibitors cells.

Language: Английский

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Light Spectrum Variations: Implications for Growth and Bioactive Compound Synthesis in Trigonella persica

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106117 - 106117

Published: Feb. 1, 2025

Language: Английский

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Novel insecticidal properties of bioactive zoochemicals extracted from sea urchin Salmacis virgulata

Open Chemistry, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 1, 2025

Abstract The present investigation assessed the insecticidal potential of zoo chemicals extracted from test (skeleton) and spines sea urchin Salmacis virgulata against Tribolium castaneum , Aedes aegypti Sf-9 cell line through assays for in vitro acetylcholinesterase (AChE) inhibition, cytotoxicity, repellency, larvicidal activity, silico modeling. Gas chromatography–mass spectrometry (GC–MS) analysis 50% ethanolic extract identified 40 distinct zoochemicals, including four with known pesticidal properties, S. . exhibited promising demonstrated by AChE inhibition an IC 50 143.41 µg/ml. Additionally, cytotoxicity was measured EC 194.68 µg/ml, a repellent index (IR) less than 0.80, LC toxicity 153.205 Further statistical computational techniques confirmed activity spine zoo-extract T. A. zoochemicals that are similarly involved on all selected insecticide molecular targets have very strong correlation, range r = 0.977–0.995. This highlights positive correlation between target evidence zoological insecticides harmful pests enzyme repellence, larvae toxicity. We recommend utilization waste as source insecticides. These bio-based pesticides offer eco-friendly approach to pest control their repellency toxicity, being readily biodegradable presenting lower environmental risks compared synthetic pesticides.

Language: Английский

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Bioactive Compounds of Marine Sponge Amphimedon viridis and Aaptos pernucleata Using GC-MS Analysis

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1488(1), P. 012113 - 012113

Published: April 1, 2025

Abstract Marine sponges are rich sources of bioactive compounds with a wide range structures and potential applications. This study aims to examine the in marine Amphimedon viridis Aaptos pernucleata by using GC-MS analysis ethanol extracts. The revealed that A. contained diethyl phthalate (30.73%), cholesterol (12.21%), desmosterol (3.25%), hexadecenoic acid methyl ester (3.44%), 9-octadecenoic (2.18%), gamma sitosterol (1.33%). major found were (28.86%), bis (2-ethylhexy) (18.71%), acid, 12-hydroxy-methyl (10.07%), cholecalciferol (8.24%), cyclopenta [g]-2-benzopyran, 1,2,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl (2.90%). These have promising development new pharmaceuticals therapeutic agents. provides an overview chemical composition extract from , as well their beneficial effect on biological activity.

Language: Английский

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Phytochemical Investigation of Aristolochias ringens (Vahl.) n-hexane root extract using GC-MS and FTIR

Tropical Journal of Phytochemistry and Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 4(3), P. 111 - 111

Published: March 31, 2025

Aristolochia ringens (Vahl.) has been featured in traditional medicinal practices to manage several diseases. This work aims investigate the phytochemical contents of n-hexane root extract and functional groups present using Gas Chromatography-Mass Spectrometry (GC-MS) Fourier Transform Infrared (FTIR) Spectroscopy methods analysis also discuss major minor compounds detected with their biological activities. The plant material was extracted by macerating for 72 h. concentrated dryness a rotary evaporator then screened secondary metabolites. FTIR were investigated GCMS-QP2010SE Shimadzu (Japan) fitted an MS (Model EI) Agilent spectrophotometer (USA). Sixty-two GC-MS identified NIST 11 library. consist terpenes (28.97%), steroids D-modified steroid (17.54%), cannabinoids (23.56%), esters (14.78%), epoxides (3.74%), alkanol, alkynol, phenolic (3.00%), organosilicone (5.43%), alkanones nitroalkanone (0.41%), hydrocarbons chlorohydrocarbon (1.98%), pyrazine ester (0.11%), dioxocin (0.47%), fatty acid (0.01%). Three are detected, most abundant cannabinoid is cannabinol. OH-stretch (3327 cm⁻¹), C-H-stretch (2921 cm⁻¹ 2854 C=O stretch (1711 C=C (1640 1462 C-O ether epoxide (1380 alkanol (1171 1074 cm⁻¹). study revealed rich extract, diverse properties. These results further explained ethnomedicinal uses plant.

Language: Английский

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Cheminformatics-based design and biomedical applications of a new Hydroxyphenylcalix[4] resorcinarene as anti-cancer agent

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 13, 2024

Abstract The distinct conformational characteristics, functionality, affordability, low toxicity, and usefulness make calixarene-based compounds a promising treatment option for cancer. aim of the present study is to synthesize new compound assess its anticancer potential on some human cancer cells. synthesized C-4-Hydroxyphenylcalix[4] resorcinarene ( HPCR ) was characterized by several spectroscopic techniques such as 1HNMR, 13CNMR, X-ray crystallographic analysis confirm purity identity. IC 50 values were identified cell lines (U-87, MCF-7, A549) dermal fibroblasts line (HDF) after with standard drug Cisplatin. A significant selective growth inhibitory activity against U-87 A549 obtained at an concentration 100 μM. MOE docking module (version 2015) utilized extent inhibition four cancer-related proteins (3RJ3, 7AXD, 6DUK, 1CGL).

Language: Английский

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The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5543 - 5543

Published: July 20, 2023

Colon cancer is one of the most common types worldwide, and its incidence increasing. Despite advances in medical science, treatment colon still poses a significant challenge. This study aimed to investigate potential protective effects Adiantum pedatum (AP) extract and/or piceatannol on induced via phenylhydrazine (PHZ) terms antioxidant apoptotic pathways histopathologic changes colons male albino rats. The rats were randomly divided into eight groups: control, AP extract, (P), PHZ, PHZ treatments, P both P, prophylaxis with P. results demonstrated that oxidative damage, apoptosis, histopathological compared control group. However, administration or + as therapy significantly ameliorated these upregulated colonic mir-145 mRNA expression P53 PDCD-4 while downregulating PI3K, AKT, c-Myc, CK-20, SOX-2, OCT-4, NanoG These findings suggest candidate drugs may exert their anti-cancer through multiple mechanisms, including activities.

Language: Английский

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Ethnopharmacological validation of Karkataka Taila-An edible crab Rasayana in rotenone-induced in vitro and in vivo models of Parkinson's disease

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118691 - 118691

Published: Aug. 10, 2024

Language: Английский

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Anabasis setifera leaf extract from arid habitat: A treasure trove of bioactive phytochemicals with potent antimicrobial, anticancer, and antioxidant properties

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0310298 - e0310298

Published: Oct. 25, 2024

The main objective of this study was to evaluate the biological activities Anabasis setifera extract, including its antimicrobial, anticancer, and antioxidant properties. In current study, leaves extract evaluated for phytochemical analyses. Ethyl acetate (EA-AS) exhibited promising antimicrobial activity toward Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, Bacillus subtilis, Candida albicans, Aspergillus brasiliensis, fumigatus with MICs 62.5, 125, 31.25, 125 μg/mL respectively. Moreover, EA-AS showed anticancer at safe concentrations, where IC50 were 36.4 44 Hep-G2 MCF-7 cancerous cell lines. found contain 55 significant compounds identified through gas chromatography mass spectrophotometry (GCMS). most abundant 1,4-dimethoxy-6,7,8,9-tetrahydro-5-benzocycloheptenone (26.04%), hexa-2,4-diyn-1-ylbenzene (8.40%), dihydrobenzo[b]fluoranthene (6.10%), ethanone, 1-[2,3-dihydro-2-(1-methylethenyl)-5-benzofuranyl valerenol (4.08%). GC analysis confirmed properties AS by detecting several activity, hexa-2,4-diyn-1-ylbenzene, nerolidol, spathulenol, -naphthalenem ethanol, decahydro-4-trimethyl-8-methylene, hexadecenoic acid, tremetone, desmethoxyencecalin, heptadecyn-1-ol, thunbergol, hexadecanol, dotriacontane, taylorione, ligulatin, retinoic falcarinol. reveals that it is a rich source valuable phytochemicals: total Phenolic Content: 4,264 /, suggesting substantial pharmacological potential. Total tannin content: 391.17 μg/mL, indicating potential applications in industries like nutraceuticals, pharmaceuticals, cosmetics. flavonoid content exceptionally high 5,163 while alkaloid measured 1,036.26 μg/mL. Additionally, demonstrated an EC50 30.6 conclusion, comprehensive immense as phytochemicals diverse bioactivities, warranting further in-depth studies unlock full pharmaceutical commercial prospects. Our results suggest prospects potent antioxidant.

Language: Английский

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