Chili Pepper as a Functional Food: Relevance to Lesotho DOI Creative Commons

Mamakase Grace Sello,

Teboho Lekatsa

International Journal of Food Sciences, Journal Year: 2023, Volume and Issue: 6(1), P. 15 - 25

Published: Sept. 1, 2023

Purpose: Although the use of chili peppers as functional foods in Lesotho is not well documented, their production and consumption have a rich historical background. Functional are those that serve therapeutic agents addition to nutrition. Previous research supports many health benefits consuming peppers, including potential mitigate risk cancer, cardiac arrhythmias, rheumatism, chest colds. Nevertheless, these concepts yet translate into tangible alterations policies implementation strategies. Therefore, this review aims identify topics for future on Chili food, food product development; improve population's well-being Methodology: This paper presents literature analysis existing data foods, specifically emphasizing applicability Lesotho, developing country. Findings: Based reviewed research, it can be inferred who regularly incorporate diet exhibit decreased death from non-communicable diseases compared do not. Unique Contribution Theory, Practice Policy: The presented classification pepper while also importance investigating effectiveness, safety, quality, development, possible hazards particularly nations like Lesotho. present study has great provide novel global perspectives associations between (NCDs), mortality guide research. Hence, endeavors must thoroughly examine distinct impacts through more clinical studies. Moreover, further will contribute revising Lesotho’s dietary guidelines advancing products, such herbal supplements derived peppers.

Language: Английский

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction DOI Creative Commons
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

Citations

17
Capsaicin Attenuates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Autophagy Through Regulation of the TRPV1/AKT Pathway DOI Creative Commons
Qin Hu, H. Liu, Ruiyu Wang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 153 - 170

Published: Jan. 1, 2024

Purpose: Acute lung injury (ALI) is a severe pulmonary disease characterized by damage to the alveoli and blood vessels, leading impairment of function. Studies on effect capsaicin (8-methyl-N-geranyl-6-nonamide, CAP) lipopolysaccharide (LPS)-induced ALI in bronchial epithelial cells transformed with Ad12-SV40 2B (BEAS-2B) are still limited. This study aimed investigate specific mechanism which CAP improves LPS-induced ALI. Methods: The present investigated potential underlying mechanisms vitro vivo via RNA sequencing, Western blotting (WB), quantitative real-time reverse transcription PCR (qRT‒PCR), enzyme-linked immunosorbent assay (ELISA), transmission electron microscopy (TEM). TRPV1 inhibitor AMG9810 AKT agonist SC79 were used confirm protective TRPV1/AKT axis against autophagy rapamycin (Rapa) inhibitors 3-methyladenine (3-MA) bafilomycin A1 (Baf-A1) clarify characteristics autophagy. Results: Our findings demonstrated that effectively suppressed inflammation ALI, both vitro. involves regulation signaling pathway. By activating TRPV1, reduces expression P-AKT, thereby exerting its anti-inflammatory inhibitory effects pro-death Furthermore, prior administration provided substantial protection mice induced LPS, reduced wet/dry ratio, decreased proinflammatory cytokine expression, downregulated LC3 expression. Conclusion: Taken together, our results indicate protects inhibiting inflammatory responses autophagic death through pathway, presenting novel strategy for therapy. Keywords: capsaicin, acute injury, Inflammation, autophagy,

Language: Английский

Citations

5
Varietal influence on bioactive compounds and antioxidant activity in chilies during development stages DOI Creative Commons
Most. Jesmin Akhter, Sumaia Akhter,

Shanta Islam

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37406 - e37406

Published: Sept. 1, 2024

Numerous cultivars of chili are grown in Bangladesh for their nutritional and sensory attributes, serving as both spices food items. Among many, indigenous include Sada Akshi, Kajini, Dhani, Naga the important ones. The functional qualities peppers attributed to plentiful presence bioactive substances. Consequently, this study aimed determine variations compounds, antioxidant activities, hotness among pre-mature, mature, pre-ripening, ripening stages four distinct cultivars. Four different chilis at maturity were collected analyzed profiles. findings research revealed that all varieties exhibited a notable range vitamin C concentration, ranging from 1.67 8.45 mg/g FW during stages. values TPC, TFC, total carotenoids, chlorophyll b ranged 16.68 46.76 mg GAE/g, 2.80-8.53 QE/g, 4.31-85.79 μg/g DW, 2.83-15.54 0.74-5.66 DW on dry weight basis, respectively. activity was assessed using FRAP DPPH scavenging assay 142.62 311.03 mM Fe (II) Equivalent/100g 216.36-329.52 μM Trolox Equivalent/g content C, increased with development. also development However, fluctuated chili. Furthermore, incorporated evaluation physical parameters, such height, weight, color attributes concerning chilies. variety demonstrated highest level efficacy when compared other varieties. physicochemical information might be useful breeders, spice processors, consumers desired size, taste, health-promoting eventually determining harvest time.

Language: Английский

Citations

4
Nano-encapsulated biostimulant enhances growth and postharvest quality of chili peppers (Capsicum annuum) DOI Creative Commons
Stella Matthews, Asgar Ali, Yasmeen Siddiqui

et al.

Scientia Horticulturae, Journal Year: 2025, Volume and Issue: 340, P. 113920 - 113920

Published: Jan. 1, 2025

Language: Английский

Citations

0
Therapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes DOI Creative Commons
Virendra Kumar Yadav, Sheersha Pramanik, Saad Alghamdi

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 403 - 444

Published: Jan. 1, 2025

Abstract: Nanotechnology has emerged as a revolutionary domain with diverse applications in medicine, and one of the noteworthy developments is exploration bacterial magnetosomes acquired from magnetotactic bacteria (MTB) for therapeutic purposes. The demand natural nanomaterials biomedical field continuously increasing due to their biocompatibility eco-friendly nature. MTB produces uniform, well-ordered magnetic nanoparticles inside magnetosomes, drawing attention unique remarkable features. have gained popularity cancer treatment diagnosis, especially resonance imaging. Distinctive features highlighted include advancements extraction, characterization, functionalization techniques, alongside breakthroughs utilizing MTB-based contrast agents imaging, biocompatible drug carriers, tools minimally invasive therapies. nature, functionalizing surface response external make them potential candidate theragnostic purpose magnetosomes. In present review, emphasis been given foundation at genetic level, mass production etc. Further authors reviewed various methods treatment. Finally, recent magnetosome-based detection, Challenges such scalability, long-term safety, clinical translation are also discussed, presenting roadmap future research exploiting MTBs magnetosomes' properties. Keywords: bacteria, hyperthermia, gene therapy, nanomedicine

Language: Английский

Citations

0
A comprehensive review on sustainable strategies for valorization of pepper waste and their potential application DOI
K. Sanatombi

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Abstract Pepper is an economically important crop grown worldwide for consumption as a vegetable and spice. Much waste, including plant seeds, stalks, placenta, peels, other processing byproducts, generated by consumers during pepper production, processing, retail, households. These peppers byproducts contain numerous bioactive compounds that can be used ingredients developing functional foods, nutraceuticals, food industries. This review summarizes the recent developments in valorization of waste. The content different wastes, their extraction processes, biological activities, applications are discussed given special attention. waste rich sources nutrients compounds, such vitamins, dietary fiber, capsaicinoids, phenolics, flavonoids, carotenoids, which possess health‐promoting effects, antioxidant, antimicrobial, anti‐inflammatory, antidiabetic, anti‐obesity, anticancer activities. Considering potential application food, pharmaceutical industries, future studies recommended to develop efficient economical green techniques evaluate sensorial characteristics, bioaccessibility, safety compounds. Several strategies also available technologies valorize possible than biomedical However, sustainability check joint effort stakeholders at all levels key reducing sustainable

Language: Английский

Citations

0
Preparation and properties of raspberry functional chewable tablets DOI
Guorui Yang, Jingru Zhao, Yaping Li

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract Raspberry possesses several health benefits such as antitumor, antioxidant, and blood sugar‐regulating activities. In order to improve the use value of raspberries, optimal preparation process raspberry chewable tablets (RCT) its physical, chemical, hypoglycemic properties were investigated in this research. The optimum formulation RCT was determined 39.1% powder, 13.1% red beet root 9.8% corn starch, 15% microcrystalline cellulose, 14% mannitol, 1% magnesium stearate, 8% ethanol (75%) by single‐factor experiment response surface methodology using sensory evaluation score hardness parameters. prepared had a 47.33 ± 2.31 N, brittleness 0.33%, weight 1.00 0.03 g, color difference Δ E = 0.427. total phenolic flavonoid contents 18.610 0.483 mg/g 3.885 0.061 mg/g, respectively. Meanwhile, seven compounds high‐performance liquid chromatography. Free radical scavenging abilities ((1,1‐diphenyl‐2‐picrylhydrazyl, DPPH), (2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid), ABTS), ·OH), ferric ion‐reducing antioxidant power cell tests proved significant ability RCT. obvious inhibitory activities on α‐glucosidase α‐amylase reflected potential. This study provided an important basis for development functional foods with glucose regulating

Language: Английский

Citations

0
Unlocking the potential of capsaicin in oral health (Review) DOI Open Access
Winny Yohana, Anggun Rafisa

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(5)

Published: Aug. 22, 2024

Capsaicin is a bioactive compound found prominently in

Language: Английский

Citations

3
Emerging diseases: trend research and omics-based analysis reveals mechanisms of endophytes modulate Chilli plant resilience DOI
Wiwiek Harsonowati, Evy Latifah, Arinal Haq Izzawati Nurrahma

et al.

Symbiosis, Journal Year: 2024, Volume and Issue: 93(3), P. 241 - 254

Published: July 1, 2024

Language: Английский

Citations

2
Phenolic Compounds and Capsaicinoids in Three Capsicum annuum Varieties: From Analytical Characterization to In Silico Hypotheses on Biological Activity DOI Creative Commons
Deborah Giordano, Angelo Facchiano, Paola Minasi

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(19), P. 6772 - 6772

Published: Sept. 22, 2023

The affinity of specific phenolic compounds (PCs) and capsaicinoids (CAPs) present in three Capsicum annuum varieties (Friariello, Cayenne Dzuljunska Sipka) to the transient receptor potential vanilloid member 1 (TRPV1) was investigated by integrating an analytic approach for simultaneous extraction analysis through high-performance liquid chromatography coupled with ion trap mass spectrometry (HPLC/ITMS) UV detection (HPLC-UV) PCs CAPs structural bioinformatics based on protein modelling molecular simulations protein–ligand docking. Overall, a total 35 were identified different samples quantified. highest content polyphenols recorded pungent Sipka variety (8.91 ± 0.05 gGAE/Kg DW) while lowest found non-pungent Friariello (3.58 0.02 DW). Protein generated first time complete model homotetrameric human TRPV1, it used docking detected via approach, as well other compounds, inhibitor reference. indicate that can interact receptor, providing details interaction, similar predicted binding energy values. These results offer new insights into interaction TRPV1 their possible actions.

Language: Английский

Citations

5