Condition-Controlled Divergent Selective Synthesis of (Z)-N-Vinyl and N-Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct N-Alkenylation Reactions DOI

Guodong Shen,

Kun Bi,

Dehe Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

We have developed a condition-controlled divergent synthesis of (Z)-N-vinyl and N-allenyl benzimidazoles from 1,1,3-triphenylprop-2-yn-1-ols through Pd- or Bi-catalyzed N-alkenylation reactions involving nucleophilic attack C-C bond cleavage processes. The desired two different kinds products can be conveniently selectively synthesized by using this strategy, which features stereospecific synthesis, good functional group tolerance, broad substrate scope, high efficiency. strategy provides significant advantages for the biologically pharmaceutically active imidazoheterocycles.

Language: Английский

Condition-Controlled Divergent Selective Synthesis of (Z)-N-Vinyl and N-Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct N-Alkenylation Reactions DOI

Guodong Shen,

Kun Bi,

Dehe Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

We have developed a condition-controlled divergent synthesis of (Z)-N-vinyl and N-allenyl benzimidazoles from 1,1,3-triphenylprop-2-yn-1-ols through Pd- or Bi-catalyzed N-alkenylation reactions involving nucleophilic attack C-C bond cleavage processes. The desired two different kinds products can be conveniently selectively synthesized by using this strategy, which features stereospecific synthesis, good functional group tolerance, broad substrate scope, high efficiency. strategy provides significant advantages for the biologically pharmaceutically active imidazoheterocycles.

Language: Английский

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