Effect of Adding Stems and Leaves of Scutellaria baicalensis Georgi to Feed on the Microbial Diversity of Cattle Feces DOI Creative Commons
Junli Zhang, Xue Bai,

Rina Na

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

Abstract Scutellaria baicalensis Georgi has important effectson anti-inflammation and anti-oxidation. However, there are few research reports on the application of stems leaves as roughage in animal husbandry. Therefore, this study aims to explore effect adding different proportions feed microbial diversity bovine feces.Twenty Simmental cattle were randomly divided into four groups: CON, 3%, 6% 9% leaves. All groups treated for 105 days. We need collect fresh faecal samples 105d microbiome feces using 16S rRNA gene sequencing. The NMDS analysis showed substantial differences bacterial community composition between treatment group CON group. At phylum level, can significantly reduce Firmicutes / Bacteroides ratio. After 6%, leaves, relative abundance Spirochaetes decreased. Verrucomimicrobia Proteobacteria These inter differential microbiota mainly participates Amino Acid Biosvthesis, Fatty Lipid Biosynthesis, Carbohydrate Degradation, Nucleoside Nucleotide Fermentation, Glycolysis, TCA cycle, Glycan Biosynthesis Degradation pathway. our shows that improve cattle's antioxidant capacity, harmful gut bacteria inflammatory reactions, promote healthy growth beef cattle. This provides a new strategy future farming.

Language: Английский

Modulating NLRP3 Inflammasomes in Idiopathic Pulmonary Fibrosis: A Comprehensive Review on Flavonoid-Based Interventions DOI Creative Commons
Megh Pravin Vithalkar, Shaili Pradhan, K. Sandra

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a severe, rapidly advancing disease that drastically diminishes life expectancy. Without treatment, it can progress to lung cancer. The precise etiology of IPF remains unknown, but inflammation and damage the alveolar epithelium are widely thought be pivotal in its development. Research has indicated activating NLRP3 inflammasome crucial mechanism pathogenesis, as triggers release pro-inflammatory cytokines such IL-1β, IL-18, TGF-β. These contribute myofibroblast differentiation extracellular matrix (ECM) accumulation. Currently, treatment options for limited. Only two FDA-approved medications, pirfenidone nintedanib, available. While these drugs decelerate progression, they come with range side effects do not cure disease. Additional strategies primarily involve supportive care therapy. Emerging research highlighted numerous flavonoids derived from traditional medicines inhibit critical regulators responsible inflammasome. show promise potential therapeutic agents managing IPF, offering new avenue targets core inflammatory processes this debilitating condition. Graphical

Language: Английский

Citations

2
Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality? DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6099 - 6099

Published: June 1, 2024

Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing death. This mode action, as well their ability be modified targeted, makes them promising avenue for advancing therapy. We are investigating the molecular mechanisms underlying interactions cells, particular interfere cellular processes induce apoptosis. The properties not accidental but due chemical structure reactivity. electrophilic nature these allows selectively target residues on disease-associated proteins, resulting significant therapeutic benefits minimal toxicity various diseases. opens up new perspectives development more effective precise drugs. Nevertheless, further studies essential fully understand impact our discoveries translate into clinical practice.

Language: Английский

Citations

13
Selected plant extracts and female fertility: role in the regulation of the hypothalamo-pituitary-ovarian axis in normal and pathological conditions DOI

Wijden Niama,

Samia Ben Saïd,

Christelle Rame

et al.

Reproduction Fertility and Development, Journal Year: 2025, Volume and Issue: 37(3)

Published: Jan. 27, 2025

Female infertility, which affects 10–20% of couples worldwide, is a growing health concern in developing countries. It can be caused by multiple factors, including reproductive disorders, hormonal dysfunctions, congenital malformations and infections. In vitro vivo studies have shown that plant extracts regulate gonadotropin-releasing hormone, kisspeptin, gonadotropin expression and/or secretion at the hypothalamic–pituitary level modulate somatic germ cells, such as steroidogenesis, proliferation, apoptosis, oxidative stress ovarian level. this review, we report evidence for role certain or bioactive compounds regulation hypothalamic–pituitary-ovary axis and, consequently, treatment female infertility. We will also summarize their possible involvement disorders polycystic ovary syndrome (PCOS), premature failure (POF) cancers.

Language: Английский

Citations

0
In silico docking, ADMET profiling, and bio-accessibility experimentation on Breynia retusa phytocompounds and in vitro validation for anti-proliferative potencies against ovarian carcinoma DOI

Benedict Mathews Paul,

Vetri Velavan Sundararajan,

Francis Jegan Raj

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 10, 2025

Language: Английский

Citations

0
Research progress on traditional Chinese medicine-induced apoptosis signaling pathways in ovarian cancer cells DOI
Yu Wang, Liangzhen Xie, Fang-Yuan Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117299 - 117299

Published: Oct. 9, 2023

Language: Английский

Citations

8
Mechanism of baicalein in treatment of castration-resistant prostate cancer based on network pharmacology and cell experiments DOI Creative Commons

Baokai Dou,

Yingjie Cui,

Qianqian Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 26, 2024

Objective Baicalein, one of the most abundant flavonoids found in Chinese herb Scutellaria baicalensis Georgi, exhibits pharmacological activities against various cancers. However, precise mechanism baicalein treating castration-resistant prostate cancer (CRPC) remains elusive. This study aimed to elucidate potential CRPC through a combination network pharmacology and experimental approaches, thereby providing new avenues for research treatment. Methods The molecular properties were obtained using TCMSP database. Baicalein-related targets collected from multiple sources including SwissTargetPrediction, PharmMapper CTD. Targets related acquired DisGeNET, GeneCards, protein-protein interaction (PPI) was analyzed STRING 11.5, Cytoscape 3.7.2 software utilized explore core on CRPC. GO KEGG pathway enrichment analysis performed DAVID Cell experiments carried out confirm validity targets. Results A total 131 treatment obtained. Among them, TP53, AKT1, ALB, CASP3, HSP90AA1, etc., recognized as by 3.7.2. function yielded 926 entries, 703 biological process (BP) terms, 84 cellular component (CC) terms 139 (MF) terms. unveiled 159 signaling pathways, mainly involved Pathways cancer, AGE-RAGE diabetic complications, TP53 pathway, PI3K-Akt etc. confirmed that may inhibit proliferation cells induce cell cycle arrest G1 phase. effect could be associated with TP53/CDK2/cyclin E1 pathway. In addition, results CETSA suggest directly bind TP53. Conclusion Based experiments, we have predicted validated pathways comprehensive approach provides scientific basis elucidating underlying action Furthermore, these findings offer valuable insights serve reference development novel anti-CRPC drugs.

Language: Английский

Citations

1
Exploring Bioactive Constituents and Pharmacological Effects of Scutellaria baicalensis Georgi: A Review DOI Creative Commons
Yan Liu,

Zhixu Gao,

Yintao Zhao

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(8)

Published: Aug. 1, 2024

Scutellaria baicalensis, commonly known as Chinese Skullcap, is a traditional herb with long history of cultural use in medicines. This review focuses on comprehensive summary the morphological description, bioactive compounds, drug-herb interactions, and pharmacological activities well its therapeutic applications. A wide-ranging search using databases such PubMed, Scopus, Google Scholar, advanced Web was conducted for data collection from prior studies. The plant root contains major active constituents including flavonoids flavo-glycosides wogonin, baicalein, baicalin, oroxylin A, scutellarein, norwogonin. These compounds have demonstrated variety activities, combating inflammation, oxidative stress, cancer, neuronal disorders, liver disorders. Skullcap represents promising avenue potential pharmacotherapeutic formulation advancement, emphasizing need further scientific exploration clinical trials.

Language: Английский

Citations

1
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer DOI Open Access

Pengyu Geng,

Jinhui Zhao,

Qi Li

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 17046 - 17046

Published: Dec. 1, 2023

Lung cancer is a malignant tumor with one of the highest morbidity and mortality rates in world. Approximately 80-85% lung diagnosed as non-small (NSCLC), its 5-year survival rate only 21%. Cisplatin commonly used chemotherapy drug for treatment NSCLC. Its efficacy often limited by development resistance after long-term treatment. Therefore, determining how to overcome cisplatin resistance, enhancing sensitivity cells cisplatin, developing new therapeutic strategies are urgent clinical problems. Z-ligustilide main active ingredient Chinese medicine Angelica sinensis, has anti-tumor activity. In present study, we investigated effect combination (Z-ligustilide+cisplatin) on cisplatin-resistant mechanism action. We found that Z-ligustilide+cisplatin decreased cell viability, induced cycle arrest, promoted apoptosis cells. Metabolomics combined transcriptomics revealed inhibited phospholipid synthesis upregulating expression phosphatase 1 (PLPP1). A further study showed PLPP1 was positively correlated good prognosis, whereas knockdown abolished effects apoptosis. Specifically, activation protein kinase B (AKT) reducing levels phosphatidylinositol 3,4,5-trisphosphate (PIP3). arrest inhibiting PLPP1-mediated synthesis. Our findings demonstrate Z-Ligustilide promising approach tumors resistant cisplatin.

Language: Английский

Citations

3
The therapeutic effect of baicalin in the treatment of bladder cancer: a mini-review DOI

Sayyid Ali Hosseini

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5

Published: July 2, 2024

Bladder cancer (BC) is one of the most common challenges endangering public health worldwide. Therefore, finding effective ways to prevent and treat this disease can significantly reduce detrimental effects BC. Baicalein a compound derived from root Scutellaria baicalensis. This possesses anticancer potential because numerous studies have confirmed its effectiveness in improving breast, liver, colon, leukaemia, skin, lung cancers. In study, we focused on reviewing latest research therapeutic baicalein treating According our findings review, baicalein, by affecting various signalling pathways such as AKT, MAPK, Survivin/CDC2, MMP, Bax/Bcl2, NF-kB, Drp1, inducing cell death, halting cellular growth cells, be an appealing approach

Language: Английский

Citations

0
The Effect of the Extraction Conditions on the Antioxidant Activity and Bioactive Compounds Content in Ethanolic Extracts of Scutellaria baicalensis Root DOI Creative Commons
Małgorzata Dzięcioł,

Klaudia Wala,

Agnieszka Wróblewska

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4153 - 4153

Published: Sept. 1, 2024

Ethanolic extracts of Baikal skullcap (Scutellaria baicalensis) root were obtained using various techniques, such as maceration, maceration with shaking, ultrasound-assisted extraction, reflux and Soxhlet extraction. The influence the type time isolation technique on extraction process was studied, quality determined by spectrophotometric chromatographic methods to find optimal conditions. Radical scavenging activity analyzed DPPH assay, while total phenolic content (TPC) method Folin–Ciocalteu reagent. Application gas chromatography mass selective detector (GC-MS) enabled identification some bioactive substances a comparison composition particular extracts. characterized both highest antioxidant compounds in 2 h main biologically active identified GC-MS wogonin oroxylin A, known for their broad spectrum biological effects, including antioxidant, anti-inflammatory, antiviral, anticancer, others.

Language: Английский

Citations

0