Sex Related Differences in the Complex Relationship between Coffee, Caffeine and Atrial Fibrillation

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3299 - 3299

Published: July 25, 2023

This literature review aims to explore the data of articles published on association between coffee, caffeine and atrial fibrillation analyze any differences two sexes. Several factors influence this complex relationship; genetic, environmental psychosocial come into play in pathophysiology fibrillation. These are expressed differently women men. However, analysis has shown that comparison works sexes extremely rare. Most population-based prospective studies either aggregated or focus exclusively male female populations. results a lack information could be useful prevention treatment approach It is necessary deepen issue with dedicated studies.

Language: Английский

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Effect of quercetin on doxorubicin cytotoxicity in sensitive and resistant human MCF7 breast cancer cell lines

Biomedical Reports, Journal Year: 2024, Volume and Issue: 20(4)

Published: Feb. 5, 2024

Chemoresistance is the major cause of cancer recurrence, relapse and eventual death. Doxorubicin resistance one such challenge in breast cancer. The use quercetin, an antioxidant, combination with doxorubicin has been investigated for offering protection to normal cells from toxic side effects addition modulation its resistance. present study aimed investigate quercetin prevention a doxorubicin‑chemoresistant phenotype both doxorubicin‑sensitive ‑resistant human MCF‑7 cell lines. A doxorubicin‑resistant line was established. development resistant closely monitored changes morphological features. Sensitivity doxorubicin/quercetin assessed using tetrazolium assay. To determine mechanism by which sensitizes MCF‑7‑resistant doxorubicin, gene expression alterations cancer‑related genes were examined reverse transcription‑quantitative PCR (RT‑qPCR) array technology. Resistant MCF successfully developed inhibitory concentration (IC₅₀) value increased 0.133 4 µM (wild‑type resistant). quercetin/doxorubicin exhibited different on wild‑type vs. cells. IC50 reduced wild cells, whereas showed increase viability at lower concentrations potentiation only higher concentrations. Annexin V/propidium iodide staining demonstrated that drives into late apoptosis necrosis, but necrosis predominates. RT‑qPCR results revealed led reversal via up‑ downregulation important as SNAI2, PLAU CSF1 genes. Downregulation migration genes, SNAI2 (‑31.23‑fold) plasminogen activator, urokinase (PLAU; ‑30.62‑fold), apoptotic pathway gene, colony stimulating factor 1 (CSF1; ‑17.25‑fold) most querticin‑associated events. Other also observed involving cycle arrest DNA repair pathways. indicated could lead CSF1. Such findings may represent potential strategy reversing cell‑related chemoresistance.

Language: Английский

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Unlocking the Potential: Quercetin and Its Natural Derivatives as Promising Therapeutics for Sepsis

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 444 - 444

Published: Feb. 16, 2024

Sepsis is a syndrome of organ dysfunction caused by an uncontrolled inflammatory response, which can seriously endanger life. Currently, there still shortage specific therapeutic drugs. Quercetin and its natural derivatives have received lot attention recently for their potential in treating sepsis. Here, we provide comprehensive summary the recent research progress on quercetin derivatives, with focus mechanisms antioxidation anti-inflammation. To obtain necessary information, conducted search PubMed, Web Science, EBSCO, Cochrane library databases using keywords sepsis, anti-inflammatory, antioxidant, anti-infection, quercetin, to identify relevant from 6315 articles published last five years. At present, 11 been intensively studied. They primarily exert anti-inflammation effects through PI3K/AKT/NF-κB, Nrf2/ARE, MAPK pathways. The feasibility these compounds experimental models clinical application were also discussed. In conclusion, good treatment

Language: Английский

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Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Language: Английский

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A Narrative Review of Quercetin’s Role as a Bioactive Compound in Female Reproductive Disorders

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1118 - 1118

Published: March 24, 2025

Lifestyle, nutrition, and metabolic status are central to maintaining women's reproductive health. With the rising prevalence of infertility, need for effective strategies preserve enhance well-being has become increasingly urgent. Quercetin, a plant-derived polyphenol, attracted growing interest its potential support health, regulate hormonal balance, improve fertility. This narrative review examines Quercetin's role in health delineates possible mechanisms action female system disorders, including polycystic ovary syndrome, recurrent miscarriage, cervical, ovarian, endometrial cancer (EC). By highlighting biological pathways through which quercetin may exert effects, this article underscores further research clinical trials validate therapeutic applications as bioactive compound foods aimed at enhancing

Language: Английский

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Ferulic acid lipid nano capsules versus its native form in alleviating diabetic nephropathy induced in rats through TGF-β1/Hippo pathway crosstalk modulation

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 31, 2025

Abstract Diabetic nephropathy is one of the most common leading causes end-stage renal disease with multifactorial pathophysiological mechanisms. TGF-β1 and Hippo pathway have been reported to significant role in different kidney diseases. In addition, ferulic acid (FA) has proposed pharmacological actions disorders such as Alzheimer, diabetes mellitus, kidney, cardiovascular diseases but limited oral use due poor absorbance bioavailability. So, recent trends aim include FA nano-formulations improve its bioavailability make best when administered orally. Thirty Sprague Dawley male rats were divided into five groups ( n = 6). After 28 days, sacrificed, serum tissue isolated, histopathological examination, creatinine level oxidative status biomarkers estimated, besides ELISA measurements TGF-β1, PTEN, COX2, GLUT3 relative gene expressions MST1 TEAD4 by qRT-PCR. Treated show improvement investigated parameters variable degrees. Noteworthy, nano-formulation shows superior action over double native form.

Language: Английский

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Exploring the protective effects of ethanolic extract of Chenopodium quinoa seed (quinoa) on the reproductive alterations of BPA-exposed females in vivo: a preliminary study

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 22, 2025

Language: Английский

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The Antioxidant Activity of Atomized Extracts of the Leaves and Stems of Cnidoscolus diacanthus (Pax & K. Hoffm.) J.F. Macbr. from Peru and Their Effect on Sex Hormone Levels in Rats

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4554 - 4554

Published: Sept. 25, 2024

In this research, we aimed to determine the antioxidant activity of an atomized extract Cnidoscolus diacanthus (Pax & K. Hoffm.) J.F. Macbr., known in Peru as “huanarpo hembra”, and its effect on sex hormone levels. Its phytochemical profile was determined using liquid chromatography–mass spectrometry (LC–MS), while total phenol content (TPC) flavonoids (TFs) were Folin–Ciocalteu method aluminum chloride method. 2,2-diphenyl-1-picrylhydrazyl (DPPH), radical 2,2-azino-bis-3-ethylbenzthiazolin-6 sulfonic acid (ABTS), ferric-reducing power (FRAP). The biological C. sexual hormones Holtzman rats both sexes. Phytochemical analysis revealed presence phenolic compounds leaves stems, mainly rutin, quercetin, chlorogenic acid, genistein. However, stem contained higher (464.38 ± 4.40 GAE/g) flavonoid (369.17 3.16 mg QE/g extract) contents than leaf (212.38 3.19 GAE/g 121.49 2.69 QE/g). For DPPH, ABTS, FRAP, Trolox-equivalent capacity (TEAC) 597.20 5.40 µmol/g, 452.67 5.76 535.91 1.56 respectively, for leaves, it 462.39 3.99 202.32 5.20 198.13 1.44 respectively. terms values hormonal levels, at a dose 100 mg/kg extract, testosterone levels 1.430 ng/mL (with 1.433 extract), found male rats. Regarding estradiol female rats, these 10.425 (leaf 8.775 (stem their luteinizing 0.320 mIU/mL 0.273 extract). follicle-stimulating hormone, 0.858 0.840 0.220 0.200 It is concluded that had greater extracts superior compared

Language: Английский

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The state of the liver, reproductive and musculoskeletal systems in female rats with pro-longed exposure to α-cypermethrin

Regulatory Mechanisms in Biosystems, Journal Year: 2024, Volume and Issue: 15(2), P. 235 - 244

Published: April 21, 2024

Pyrethroid insecticides are currently a widely used class of pesticides. It is therefore important to determine the mechanism disorders in some mammalian systems due prolonged exposure these pesticides and justify means prevent poisoning complications. The study was conducted on 30 female rats aged 3 months for 120 days. Intoxication modeled using α-cypermethrin at dose 10 mg/kg. prevention intoxication complications carried out with an adaptogenic complex consisting flavonoid quercetin, vitamins C D3, minerals (Ca, Mn, Zn, Cu, Se, Mg) 500 Assessment preventive efficacy adaptogen performed by determining duration estrous cycle, ovarian organ index, degree atrophy alveolar process jaws, as well density, content mineral organic components bones. Hepatotoxicity markers were determined blood serum, osteoresorption bone homogenate, inflammation indicators liver, antioxidant system status all tissues. Prolonged associated prolongation cycle reduction diestrus stage decrease index along significant increase estradiol levels. In intoxicated animals, increased density femurs vertebrae decreased weight fraction component tissue process, activity elastase oxidative stress (an malondialdehyde catalase activity), compensatory alkaline phosphatase found. rat acid inhibition defense observed. An found serum animals. use under conditions contributed normalization femur rats, treatment prophylactic led component, which activation enzymatic link destructive too developed prevented development liver results research indicate negative effect sexual function state hepatotoxic pesticide. proposed agent effectively endocrine disruption ovaries, destruction liver.

Language: Английский

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Pomegranate peels ethanolic extract in free and nanoemulsified forms around mating and early pregnancy differently affect heat tolerance capacity and reproductive performance of ewes under heat stress

Journal of Thermal Biology, Journal Year: 2024, Volume and Issue: unknown, P. 104043 - 104043

Published: Dec. 1, 2024

Language: Английский

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