Synthesis of Indenoindole Derivatives under Deep Eutectic Solvent Conditions DOI
Sambasivarao Kotha, Mohammad Salman, Subba Rao Cheekatla

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract In this study, we synthesized a variety of indole derivatives using commercially available 2,5‐dimethoxybenzaldehyde 18 as starting material. The synthetic route involves sequential usage Knoevenagel and Fischer indolization reactions key steps the is facilitated by deep eutectic solvent (DES) such L‐tartaric acid/dimethylurea (TA:DMU). All compounds prepared here are characterized HRMS, 1 H‐NMR 13 C‐NMR data. methodology described in study showcases utility solvents facilitating synthesis diverse derivatives, thereby expanding toolkit sustainable methodologies. These medicinally important play role an effective template Kinase inhibitors (CK2). Various functionalized indeno[ 1,2‐b ]indole scaffolds might be valuable novel human CK2. Elevated levels protein kinase CK2, previously known casein 2 or II, have been linked to higher cell growth proliferation both normal cancerous cells.

Language: Английский

Carbonic anhydrase inhibitors: Structural insights and therapeutic potential DOI
Priti Singh, Mohammed Arifuddin,

Claudiu T. Supuran

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108224 - 108224

Published: Jan. 1, 2025

Language: Английский

Citations

3
Synthesis of 5-heptadecyl-4H-1,2,4-triazole incorporated indole moiety: Antiviral (SARS-CoV-2), antimicrobial, and molecular docking studies DOI

Hayam A. Abd El Salam,

Heba M. Abo‐Salem, Omnia Kutkat

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137517 - 137517

Published: Jan. 14, 2024

Language: Английский

Citations

9
Magnetic nanoparticle-catalyzed synthesis of indole derivatives: a green and sustainable method DOI

Vaishali Vaishali,

Shubham Sharma,

Sultan Ensaaf

et al.

Monatshefte für Chemie - Chemical Monthly, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Language: Английский

Citations

1
Unveiling an indole derivative YM818 as a novel tyrosinase inhibitor with anti-melanogenic and anti-melanin transfer effects DOI
Chunyan Yang,

Hoi Kiong Lai,

Xiaoyu Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141557 - 141557

Published: Feb. 1, 2025

Language: Английский

Citations

1
Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014–2024) review DOI
Amol A. Nagargoje, Tejshri R. Deshmukh, Mubarak H. Shaikh

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(9)

Published: June 19, 2024

Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with Numerous research articles in recent years have emphasized the significance as effective agents. This review focuses on latest advances potential MACs, from 2014 to 2024, including discussions their mechanism action, structure-activity relationship (SAR), and silico molecular docking studies.

Language: Английский

Citations

4
Functionalization of Indoles with 1,3,5-Triazinanes: Chemistry of Aminomethylation vs the Hofmann–Martius-Type Rearrangement DOI
Vishnu K. Omanakuttan,

Elza Maria Varghese,

R. Alvarez-Manzaneda R.

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

We have developed efficacious routes toward the selective synthesis of two classes compounds such as C-3 amino-methylated indoles and 4-indol-3-yl-methylanilines from same precursors, namely, 1,3,5-triazinanes. It is reported that controlled cleavage 1,3,5-triazinanes can be effected by heat for generation aryl imine motifs, we observed presence Lewis acid influences course these transformations different products. The reaction indol-3-yl-methylanilines proceeds via a nucleophilic attack indole to generated form an product which undergoes mediated Hofmann-Martius-type rearrangement. In absence acid, between 1,3,5-triazinane afforded indoles. Experimentally, could prove was intermediate formed during catalyzed process in intermolecular fashion. both found general, library molecules generated.

Language: Английский

Citations

0
Sulfenylcarbene-Mediated Carbon Atom Insertion for the Late-Stage Functionalization of N-Heterocycles DOI

Prakash Kafle,

Deacon Herndon,

Indrajeet Sharma

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Late-stage functionalization (LSF) is a crucial strategy in drug discovery, allowing the modification of complex molecules, including pharmaceuticals, to enhance chemical diversity libraries. We harness chemoselectivity sulfenylcarbenes, which selectively react with alkenes even presence more reactive functional groups such as alcohols, carboxylic acids, and amines. This reactivity allows sulfenylcarbenes insert single carbon atom bearing diverse groups, transforming pyrroles, indoles, imidazoles into synthetically challenging pyridines, quinolines, pyrimidines, respectively. Sulfenylcarbene precursors are easily synthesized two steps from commercially available reagents. Our metal-free LSF approach employs benchtop-stable sulfenylcarbene enables late-stage natural products, amino C-glycosides. Mechanistic studies density theory (DFT) calculations were conducted investigate regio- outcomes.

Language: Английский

Citations

0
Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids DOI
Mostafa Sayed, Ahmed M. Sayed, Ahmed A. El‐Rashedy

et al.

Current Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(1), P. 56 - 64

Published: Jan. 1, 2024

Abstract: This research paper embarks on an interdisciplinary exploration encompassing synthetic chemistry, pharmacology, and computational biology. The development of novel anti-inflammatory agents is imperative endeavor within pharmaceutical research. Pyrimidines thienopyrimidines are class heterocyclic compounds that have gained prominence for their diverse pharmacological properties, including potential effects. When augmented with indole moiety, these exhibit structural diversity can profoundly influence biological activities. integration biology specifically molecular docking, plays a crucial role in predicting understanding the binding interactions between select protein targets associated inflammatory pathways. approach expedites screening drug candidates elucidates underpinnings actions. Pyrimidine tethering scaffold were obtained according to our reported methods. Subsequently, vivo evaluation indispensable gauge establish structure-activity relationships. experimental studies target indole-pyrimidines hybrids revealed serve as agents. potentially open new avenues therapeutic strategies against inflammation-associated disorders. synergy innovation, evaluation, insights offers holistic advance pyrimidines moiety mitigating inflammation.

Language: Английский

Citations

2
Synthesis of indole derivatives from the S 3 •− -mediated intramolecular cyclization of o -alkynylanilines DOI

Zhaoxin Jing,

Jiakai Wu, Shuyi Li

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(14), P. 1147 - 1158

Published: July 9, 2024

Language: Английский

Citations

0
Synthesis of Indenoindole Derivatives under Deep Eutectic Solvent Conditions DOI
Sambasivarao Kotha, Mohammad Salman, Subba Rao Cheekatla

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract In this study, we synthesized a variety of indole derivatives using commercially available 2,5‐dimethoxybenzaldehyde 18 as starting material. The synthetic route involves sequential usage Knoevenagel and Fischer indolization reactions key steps the is facilitated by deep eutectic solvent (DES) such L‐tartaric acid/dimethylurea (TA:DMU). All compounds prepared here are characterized HRMS, 1 H‐NMR 13 C‐NMR data. methodology described in study showcases utility solvents facilitating synthesis diverse derivatives, thereby expanding toolkit sustainable methodologies. These medicinally important play role an effective template Kinase inhibitors (CK2). Various functionalized indeno[ 1,2‐b ]indole scaffolds might be valuable novel human CK2. Elevated levels protein kinase CK2, previously known casein 2 or II, have been linked to higher cell growth proliferation both normal cancerous cells.

Language: Английский

Citations

0