Transition‐metal‐free Cyclization of Mucohalic Acids with Sulfonyl Hydrazides: An Approach to Pyridazin‐3(2H)‐ones DOI
Qi Chen, Huanqing Li, Kai Yang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(11)

Published: Sept. 18, 2023

Abstract An eco‐friendly and efficient synthesis of pyridazin‐3(2 H )‐ones from aromatic sulfonyl hydrazides mucohalic acids has been developed. This facile strategy is carried out smoothly via the promotion simple organic acid p ‐toluenesulfonic acid, able to form two C−N bonds a heterocycle linking potentially bioactive group at one‐step. The protocol tolerant various readily available substrates in good yields, as desired products are key structural fragments many compounds. More importantly, gram‐scale cyclization reaction novel approach derivatives successfully reveals its practicability.

Language: Английский

Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates DOI
Cong Ma, Long Yin Lam

Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or derivatives, which are associated with unpleasant odors potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl oxyacids, sulfoxides, thiol surrogates for thioether synthesis. This review highlights recent advancements deoxygenative synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, hydro/halo/oxy-thiolation unsaturated hydrocarbons. We also discuss representative mechanisms to provide comprehensive understanding these innovative approaches. 1 Introduction 2 Cross-Coupling Reactions 3 Functionalization 4 Hydro/Halo/Oxy-thiolation Unsaturated Hydrocarbons 5 Conclusion

Language: Английский

Citations

1
Na+ detection via brightening of synergistically originated noble metal nanoclusters DOI Creative Commons
Priyanka Sharma, Mainak Ganguly, Mamta Sahu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(43), P. 31624 - 31632

Published: Jan. 1, 2024

Synergistically originated AuAg nanoclusters were remarkably brightened in the presence of Na + .

Language: Английский

Citations

3
Synthesis of (E)‐β‐Iodovinyl Sulfones via HI‐mediated Vicinal Iodosulfonylation of Alkynes with Sodium Sulfinates DOI

Zu‐Jia Chen,

Yu Zeng,

Zhonghao Li

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(6)

Published: March 21, 2024

Abstract Hydroiodic acid‐mediated vicinal iodosulfonylation reaction of alkynes with sodium sulfinates is proposed for the synthesis ( E )‐ β ‐iodovinyl sulfones. The method easy to operate, environmentally friendly, using inexpensive and easily available raw materials, giving target products good regio‐ stereoselectivity in satisfactory yields.

Language: Английский

Citations

2
Iodine-Promoted Disproportionate Coupling Reaction of Arylsulfonyl Hydrazides: A Simple and Green Access to Thiosulfonates DOI
Qi Chen,

Zhao-Hua Chen,

Shi‐Wei Yu

et al.

Synthesis, Journal Year: 2024, Volume and Issue: 56(09), P. 1415 - 1421

Published: Jan. 17, 2024

Abstract An environmentally friendly iodine-promoted disproportionate coupling reaction of arylsulfonyl hydrazides is reported. This strategy can synthesize thiosulfonates with medium to excellent yields, and features a green system, wide applicability substrates, easy availability raw materials. The preliminary mechanistic study reveals that iodine plays an important role in the radical process.

Language: Английский

Citations

1
3,4-Dihalo-5-hydroxy-2(5H)-furanones: Highly Reactive Small Molecules DOI Creative Commons
Katarzyna Żurawska, Anna Byczek-Wyrostek, Anna Kasprzycka

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5149 - 5149

Published: Oct. 31, 2024

3,4-Dichloro-5-hydroxy-2(5

Citations

1
Transition‐metal‐free Cyclization of Mucohalic Acids with Sulfonyl Hydrazides: An Approach to Pyridazin‐3(2H)‐ones DOI
Qi Chen, Huanqing Li, Kai Yang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(11)

Published: Sept. 18, 2023

Abstract An eco‐friendly and efficient synthesis of pyridazin‐3(2 H )‐ones from aromatic sulfonyl hydrazides mucohalic acids has been developed. This facile strategy is carried out smoothly via the promotion simple organic acid p ‐toluenesulfonic acid, able to form two C−N bonds a heterocycle linking potentially bioactive group at one‐step. The protocol tolerant various readily available substrates in good yields, as desired products are key structural fragments many compounds. More importantly, gram‐scale cyclization reaction novel approach derivatives successfully reveals its practicability.

Language: Английский

Citations

0