Therapeutic Mechanisms of Medicine Food Homology Plants in Alzheimer’s Disease: Insights from Network Pharmacology, Machine Learning, and Molecular Docking

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2121 - 2121

Published: Feb. 27, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual decline in cognitive function. Currently, there are no effective treatments for this condition. Medicine food homology plants have gained increasing attention as potential natural AD because of their nutritional value and therapeutic benefits. In work, we aimed to provide deeper understanding how medicine may help alleviate or potentially treat identifying key targets, pathways, small molecule compounds from 10 that play an important role process. Using network pharmacology, identified 623 common targets between the selected plants, including crucial proteins such STAT3, IL6, TNF, IL1B. Additionally, molecules were grouped into four clusters using hierarchical clustering. The ConPlex algorithm was then applied predict binding capabilities these protein targets. Cluster 3 showed superior predicted IL1B, which further validated molecular docking. Scaffold analysis revealed those with steroid-like core-comprising three fused six-membered rings one five-membered ring carbon-carbon double bond-exhibited better affinities triple-target inhibitors. Among them, MOL005439, MOL000953, MOL005438 top-performing compounds. This study highlights source active could be developed new drugs treatment. However, pharmacokinetic studies essential assess efficacy minimize side effects.

Language: Английский

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Utilizing data mining and network pharmacology to analyze the formulation rule and function of enhancing immunity of Acanthopanax Radix et Rhizoma‐containing health products

Advanced Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Objective This study aims to analyze the formulation rules of Ciwujia ( Acanthopanax Radix et Rhizoma )‐containing health products and investigate potential mechanisms. Methods By searching Ciwujia‐containing from special food information inquiry platform State Administration for Market Regulation MedSciNet, basic information, including efficacy, tropism taste, dosage form, function etc., was analyzed using R language software packages Excel. The core drug combinations were Apriori algorithm IBM SPSS Modeler 18.0. TCMID other databases reviewing relevant literature, chemical components targets database constructed. protein–protein interaction network package, String database, Cytoscape screen key related functions. Gene ontology functional annotation Kyoto encyclopedia genes genomes pathway enrichment analysis performed. Finally, molecular docking used verify binding affinity components. Results A total 315 cases collected. major functions relieve physical fatigue immune enhancement. 205 effective 775 obtained. intersecting enhancement, 212 target identified. has an effect on enhancement through signaling pathways such as C‐type lectin receptor, toll‐like NOD‐like receptor. Molecular results also indicated a spontaneous stable between targets. Conclusions Through data mining, pharmacology, research, this products, preliminarily revealing its mechanism providing theoretical basis development future products.

Language: Английский

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Potassium and Magnesium in American Ginseng Roots as Key Factors in Monitoring Soil Quality, Yield, and Quality: Screening, Prediction, and Validation

Horticulturae, Journal Year: 2024, Volume and Issue: 10(4), P. 344 - 344

Published: March 29, 2024

Understanding the key roles of nutrient elements in soil–plant systems are essential for herbal medicine production and sustainable development. However, ecological relationships between soil quality elements, yield, saponins, or other active compounds American ginseng remain unclear. In this study, 20 indicators, 10 root 9 yields were investigated. The minimum dataset was constructed by principal component analysis, factors screened correlation analysis PLS-PM prediction model using linear fitting tested a validation test. dataset, based on comprised five indicators: SOM, TP, AK, AMg, ACa. Correlation showed that K Mg relating to yield when AMg 0.21 g/kg AK 0.30 g/kg, organic matter 27%, total phosphorus 1.19 soil, content roots 15.63 1.91 K/Mg 8.85 could balance quality. predicting validating model, DW, ginsenoside, Rb1, Rb2, Rc, Rd reliable. This study provides scientific basis regulation, selecting planting sites, assessing quality, evaluating

Language: Английский

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Phytotherapy in Alzheimer’s Disease—A Narrative Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1812 - 1812

Published: Aug. 9, 2024

Alzheimer's disease (AD) affects 50-70% of patients with dementia, making it the leading cause dementia. The condition is classified as a neurodegenerative, progressive and incurable disease. affecting more people around world. AD has multifactorial nature, spreading from beta-amyloid deposition to inflammation in patients' brains. Patients experience cognitive impairment functional decline. Although that occurs mainly elderly, increasingly being diagnosed young between ages 30 40. It not only patient themself but also reduces quality life their closest caregivers. According WHO, treatment consumes USD 1.3 trillion globally, symptomatic, there are no drugs prevent onset or treat its onset. Due numerous side effects therapy lack proactive act on pathomechanism AD, alternative therapies sought. One possible option many studies confirming effect phytotherapy. Many herbs have pharmacological properties, such antioxidant, anti-inflammatory, neuroprotective effects, them future disorders treatment. This review focuses some most promising potentially potent properties therapy. These include

Language: Английский

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Traditional Herbal Medicine for Dementia Therapy

Published: Jan. 1, 2024

Language: Английский

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Panax Quinquefolium Saponins protects neuronal activity by promoting mitophagy in both in vitro and in vivo models of Alzheimer's disease

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119250 - 119250

Published: Dec. 1, 2024

Language: Английский

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