New Cannabinoids and Chlorin-Type Metabolites from the Flowers of Cannabis sativa L.: A Study on Their Neuroblastoma Activity

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 521 - 521

Published: April 3, 2025

Background/Objectives: Cannabis sativa has been utilized for medical purposes thousands of years. It continues to be recognized as a plant with an extensive variety medicinal and nutraceutical uses today. In this study, chemical investigation the flowers C. isolated by using chromatographic techniques led isolation eleven compounds. These purified compounds were evaluated antitumor activity against SK-N-SH neuroblastoma cells. Methods: The techniques. Their structures identified examination spectroscopic methods, including 1D (1H, 13C, DEPT) 2D (COSY, HSQC, HMBC, NOESY) nuclear magnetic resonance (NMR) spectra mass spectrum, together comparison those reported previously in literature. evaluation toxicity on cells was performed MTT method. Results: Eleven from sativa, two new compounds, namely cannabielsoxa (1), 132-hydroxypheophorbide c ethyl ester (2), six known cannabinoids (6–11), first chlorin-type compounds: pyropheophorbide A (3), b (4), ligulariaphytin (5) plant. results also demonstrated that cannabinoid had stronger inhibitory effects than Conclusions: biological activities showed 4–10 could considered potential neuroblastomas. This is highlighted docking analysis. Additionally, study suggest these have developed into antineuroblastoma products.

Language: Английский

Triterpenoid Saponins and Flavonoid Glycosides from the Flower of Camellia flavida and Their Cytotoxic and α-Glycosidase Inhibitory Activities

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10977 - 10977

Published: Oct. 12, 2024

var. flavida, commonly known as "Jinhua Tea", has its flowers and leaves traditionally utilized tea functional food sources. However, there is limited knowledge about bioactive components their biological activities. This study isolated ten previously unidentified glycoside compounds from the of

Language: Английский