TPP-based conjugates: potential targeting ligands
Sanya Batheja,
No information about this author
Shruti Gupta,
No information about this author
Kiran Kumar Tejavath
No information about this author
et al.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(6), P. 103983 - 103983
Published: April 18, 2024
Language: Английский
Chitosan-Coated Liposome Formulations for Encapsulation of Ciprofloxacin and Etoposide
Rubén Gil-Gonzalo,
No information about this author
D. Alonzo Durante-Salmerón,
No information about this author
Saeedeh Pouri
No information about this author
et al.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1036 - 1036
Published: Aug. 2, 2024
Cancer
and
bacterial
infections
rank
among
the
most
significant
global
health
threats.
accounting
for
roughly
25
million
fatalities
each
year.
This
statistic
underscores
urgent
necessity
developing
novel
drugs,
enhancing
current
treatments,
implementing
systems
that
boost
their
bioavailability
to
achieve
superior
therapeutic
outcomes.
Liposomes
have
been
recognised
as
effective
carriers;
nonetheless,
they
encounter
issues
with
long-term
stability
structural
integrity,
which
limit
pharmaceutical
applicability.
Chitosomes
(chitosan-coated
liposomes)
are
generally
a
good
alternative
solve
these
issues.
research
aims
demonstrate
individual
encapsulation
of
ciprofloxacin
(antibacterial,
hydrophilic)
etoposide
(anticancer,
hydrophobic),
within
chitosomes
create
more
drug
delivery
(oral
administration
ciprofloxacin,
parenteral
etoposide).
Thus,
liposomes
were
prepared
using
thin-film
hydration
technique
characterised
through
ATR-FTIR,
Dynamic
Light
Scattering
(DLS),
zeta
potential,
release
profiling.
In
both
cases,
application
enhanced
in
size
surface
charge.
Chitosome-encapsulated
formulations
exhibited
slower
sustained
profile,
while
combined
effect
chitosan
showed
heightened
efficacy
against
glioblastoma
cell
line
U373.
Therefore,
coating
improved
system's
properties,
resulting
promising
method
delivery.
Language: Английский
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy
Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(11), P. RCR5150 - RCR5150
Published: Oct. 30, 2024
Diabetes
and
its
complications
derived
are
among
serious
global
health
concerns
that
critically
deteriorate
the
quality
of
life
patients
and,
in
some
cases,
result
lethal
outcome.
Herein,
general
information
on
pathogenesis,
factors
aggravating
course
disease
drugs
used
for
treatment
two
types
diabetes
briefly
discussed.
The
aim
review
is
to
introduce
supramolecular
strategies
currently
being
developed
mellitus
present
a
very
effective
alternative
chemical
synthesis,
allowing
fabrication
nanocontainers
with
switchable
characteristics
meet
criteria
green
chemistry.
Particular
attention
paid
organic
(amphiphilic
polymeric)
formulations,
including
those
natural
origin,
due
their
biocompatibility,
low
toxicity,
bioavailability.
advantages
limitations
different
nanosystems
discussed,
emphasis
adaptivity
noninvasive
administration
routes.<br>The
bibliography
includes
378
references.
Language: Английский
Surfactant-based drug delivery systems for cancer therapy: Advances, challenges, and future perspectives
Karuppiah Nagaraj
No information about this author
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125655 - 125655
Published: May 1, 2025
Language: Английский
Self-assembly and functional activity of amphiphilic conjugates of the diterpenoid isosteviol and triphenylphosphonium cation, with focusing on biotechnological potential
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Journal Year:
2024,
Volume and Issue:
697, P. 134505 - 134505
Published: June 12, 2024
Language: Английский
Self-aggregation and antimicrobial activity of cationic benzimidazolium surfactants: Electrolyte effect on the Krafft temperature
Journal of Molecular Liquids,
Journal Year:
2025,
Volume and Issue:
424, P. 127098 - 127098
Published: Feb. 7, 2025
Language: Английский
Mitochondrial-targeted liposome-based drug delivery - Therapeutic potential and challenges
Lissette Sanchez-Aranguren,
No information about this author
Mohamad Anas Al Tahan,
No information about this author
Muhammad Uppal
No information about this author
et al.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 22
Published: Dec. 2, 2024
Liposomes,
as
nanocarriers
for
therapeutics,
are
a
prominent
focus
in
translational
medicine.
Given
their
biocompatibility,
liposomes
suitable
drug
delivery
systems
rendering
highly
efficient
therapeutic
outcomes
with
minimal
off-site
toxicity.
In
different
scenarios
of
human
disease,
it
is
essential
not
only
to
maintain
levels
but
also
target
them
the
appropriate
intracellular
compartment.
Mitochondria
regulate
cellular
signalling,
calcium
balance,
and
energy
production,
playing
crucial
role
various
diseases.
The
notion
focusing
on
mitochondria
targeted
was
proposed
several
decades
ago,
yet
practical
application
this
idea
its
translation
clinical
use
still
development.
Mitochondrial-targeted
offer
an
alternative
standard
systems,
potentially
reducing
off-target
interactions,
side
effects,
dosage
or
frequency.
.
To
advance
field,
imperative
integrate
disciplines
such
chemical
design,
pharmacology,
pharmaceutics,
cell
biology.
This
review
summarises
scientific
advances
development
characterisation
novel
liposome-based
targeting
while
revisiting
potential.
Language: Английский